Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q4 2024
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 122
- +13 vs. Q3 2024
- Shares held
- 49.8M
- +6.68M (+15.5%) vs. Q3 2024
- Total value
- $188.3M
- +$48.6M (+34.8%) vs. Q3 2024
- New holders
- 33
- 35 more added
- Sold out
- 20
- 40 more reduced
1 institution that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Perceptive Advisors LLC | 6,774,348 | $25.6M | 0.71% | +4,648,699+218.7% | Added |
| TCG Crossover Management, LLC | 4,643,812 | $17.6M | 1.72% | 00.0% | Unchanged |
| Vanguard Group Inc | 2,692,489 | $10.2M | 0.00% | −397,156−12.9% | Reduced |
| Bank of America Corp | 2,426,263 | $9.17M | 0.00% | +1,513,748+165.9% | Added |
| BlackRock, Inc. | 2,278,934 | $8.61M | 0.00% | −269,272−10.6% | Reduced |
| Almitas Capital LLC | 2,032,370 | $7.68M | 1.69% | +43,807+2.2% | Added |
| Citadel Advisors LLC | 1,970,704 | $7.45M | 0.01% | +71,144+3.7% | Added |
| 683 Capital Management, LLC | 1,930,000 | $7.30M | 0.72% | −70,000−3.5% | Reduced |
| Goldman Sachs Group Inc | 1,859,896 | $7.03M | 0.00% | +246,033+15.2% | Added |
| Boxer Capital Management, LLC | 1,750,000 | $6.62M | 0.56% | +1,750,000 | New |
| Standard Life Aberdeen plc | 1,722,805 | $6.51M | 0.01% | −249,437−12.6% | Reduced |
| Nantahala Capital Management, LLC | 1,452,153 | $5.49M | 0.38% | +47,589+3.4% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 1,263,353 | $4.78M | 0.02% | +382,608+43.4% | Added |
| Saturn V Capital Management LLC | 889,073 | $3.36M | 1.32% | +889,073 | New |
| Susquehanna International Group, LLP | 868,382 | $3.28M | 0.00% | +462,225+113.8% | Added |
| Alyeska Investment Group, L.P. | 823,420 | $3.11M | 0.01% | −1,200,000−59.3% | Reduced |
| Qube Research & Technologies Ltd | 780,566 | $2.95M | 0.00% | +596,672+324.5% | Added |
| Jane Street Group, LLC | 765,475 | $2.89M | 0.00% | +421,302+122.4% | Added |
| FMR LLC | 731,356 | $2.76M | 0.00% | +510,355+230.9% | Added |
| Two Sigma Investments, LP | 651,517 | $2.46M | 0.01% | +284,280+77.4% | Added |
| UBS Group AG | 643,524 | $2.43M | 0.00% | +414,448+180.9% | Added |
| Acadian Asset Management LLC | 611,926 | $2.31M | 0.01% | −1,158,271−65.4% | Reduced |
| Citigroup Inc | 609,324 | $2.30M | 0.00% | +34,319+6.0% | Added |
| Millennium Management LLC | 594,236 | $2.25M | 0.00% | +137,420+30.1% | Added |
| Deutsche Bank AG | 570,857 | $2.16M | 0.00% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 567,903 | $2.15M | 0.00% | +16,864+3.1% | Added |
| Walleye Capital LLC | 518,784 | $1.96M | 0.02% | −151,810−22.6% | Reduced |
| Cubist Systematic Strategies, LLC | 472,397 | $1.79M | 0.03% | +423,316+862.5% | Added |
| Renaissance Technologies LLC | 464,400 | $1.76M | 0.00% | +192,600+70.9% | Added |
| Morgan Stanley | 464,220 | $1.75M | 0.00% | −14,045−2.9% | Reduced |
| OrbiMed Advisors LLC | 348,000 | $1.32M | 0.03% | +348,000 | New |
| Jacobs Levy Equity Management, Inc | 314,939 | $1.19M | 0.00% | −163,501−34.2% | Reduced |
| D. E. Shaw & Co., Inc. | 306,744 | $1.16M | 0.00% | −384,322−55.6% | Reduced |
| Charles Schwab Investment Management Inc | 298,949 | $1.13M | 0.00% | −3,321−1.1% | Reduced |
| Aldebaran Capital, LLC | 262,753 | $993.2K | 0.94% | −7,050−2.6% | Reduced |
| Two Sigma Advisers, LP | 241,400 | $912.5K | 0.00% | −68,100−22.0% | Reduced |
| State Street Corp | 218,383 | $825.5K | 0.00% | +63,475+41.0% | Added |
| Wellington Management Group LLP | 209,708 | $792.7K | 0.00% | +209,708 | New |
| Federated Hermes, Inc. | 202,316 | $764.8K | 0.00% | +16,030+8.6% | Added |
| Ikarian Capital, LLC | 201,187 | $760.5K | 0.22% | −73,364−26.7% | Reduced |
| Schonfeld Strategic Advisors LLC | 193,931 | $733.1K | 0.00% | +27,502+16.5% | Added |
| AQR Capital Management LLC | 188,386 | $712.1K | 0.00% | −460,693−71.0% | Reduced |
| Marshall Wace, LLP | 184,678 | $698.1K | 0.00% | −99,308−35.0% | Reduced |
| Falcon Edge Capital, LP | 148,627 | $561.8K | 0.26% | −520,860−77.8% | Reduced |
| Bridgeway Capital Management, LLC | 146,500 | $553.8K | 0.01% | +16,500+12.7% | Added |
| Bank of Montreal | 143,512 | $542.5K | 0.00% | 00.0% | Unchanged |
| Kennondale Capital Management LLC | 134,445 | $508.2K | 0.55% | +134,445 | New |
| Mackenzie Financial Corp | 111,310 | $420.8K | 0.00% | +78,070+234.9% | Added |
| Northern Trust Corp | 106,564 | $402.8K | 0.00% | +11,214+11.8% | Added |
| ExodusPoint Capital Management, LP | 106,237 | $402.0K | 0.00% | +106,237 | New |
| Jump Financial, LLC | 104,342 | $394.4K | 0.01% | +104,342 | New |
| Man Group plc | 100,059 | $378.2K | 0.00% | −30,803−23.5% | Reduced |
| Tang Capital Management LLC | 100,000 | $378.0K | 0.03% | 00.0% | Unchanged |
| Hennion & Walsh Asset Management, Inc. | 90,619 | $342.5K | 0.02% | −23,915−20.9% | Reduced |
| Boothbay Fund Management, LLC | 80,543 | $304.5K | 0.01% | −4,934−5.8% | Reduced |
| Squarepoint Ops LLC | 75,284 | $284.6K | 0.00% | +27,279+56.8% | Added |
| Barclays PLC | 74,845 | $282.9K | 0.00% | −9,727−11.5% | Reduced |
| Point72 Asia (Singapore) Pte. Ltd. | 72,863 | $275.4K | 0.07% | −10,700−12.8% | Reduced |
| Omers Administration Corp | 66,000 | $249.5K | 0.00% | +66,000 | New |
| American Century Companies Inc | 59,310 | $224.2K | 0.00% | +38,261+181.8% | Added |
| Price T Rowe Associates Inc | 57,700 | $219.0K | 0.00% | +2,100+3.8% | Added |
| JPMorgan Chase & Co | 55,606 | $210.2K | 0.00% | −84,953−60.4% | Reduced |
| Alps Advisors Inc | 55,430 | $209.5K | 0.00% | +55,430 | New |
| Dimensional Fund Advisors LP | 54,114 | $204.6K | 0.00% | +54,114 | New |
| XTX Topco Ltd | 53,376 | $201.8K | 0.02% | +5,704+12.0% | Added |
| Mariner, LLC | 50,539 | $191.0K | 0.00% | −5,795−10.3% | Reduced |
| Ameriprise Financial Inc | 50,428 | $190.6K | 0.00% | +50,428 | New |
| Balyasny Asset Management LLC | 50,248 | $189.9K | 0.00% | −655−1.3% | Reduced |
| Group One Trading, L.P. | 49,899 | $188.6K | 0.01% | −79,391−61.4% | Reduced |
| Landscape Capital Management, L.L.C. | 49,661 | $187.7K | 0.02% | +49,661 | New |
| Jefferies Financial Group Inc. | 46,200 | $174.6K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 45,987 | $173.8K | 0.00% | +36,347+377.0% | Added |
| Guggenheim Capital LLC | 35,868 | $135.6K | 0.00% | +20,470+132.9% | Added |
| Centiva Capital, LP | 33,831 | $127.9K | 0.00% | +33,831 | New |
| Tudor Investment Corp Et Al | 33,687 | $127.3K | 0.00% | +33,687 | New |
| Parsons Capital Management Inc | 21,645 | $81.8K | 0.00% | −300−1.4% | Reduced |
| Marex Group plc | 20,000 | $75.6K | 0.00% | −20,000−50.0% | Reduced |
| Brown Advisory Inc | 19,930 | $75.3K | 0.00% | −20−0.1% | Reduced |
| Wedbush Securities Inc | 19,914 | $75.0K | 0.00% | +19,914 | New |
| Prudential Financial Inc | 19,400 | $73.3K | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 17,819 | $67.0K | 0.00% | −93,909−84.1% | Reduced |
| JustInvest LLC | 17,724 | $67.0K | 0.00% | +1,132+6.8% | Added |
| Engineers Gate Manager LP | 17,637 | $66.7K | 0.00% | +17,637 | New |
| State of Wyoming | 16,077 | $60.8K | 0.01% | −9,700−37.6% | Reduced |
| SG Americas Securities, LLC | 15,958 | $60.0K | 0.00% | −41,428−72.2% | Reduced |
| Y-Intercept (Hong Kong) Ltd | 14,809 | $56.0K | 0.00% | +14,809 | New |
| China Universal Asset Management Co., Ltd. | 14,535 | $54.9K | 0.01% | +1,441+11.0% | Added |
| EntryPoint Capital, LLC | 13,909 | $52.6K | 0.02% | +13,909 | New |
| Rpo LLC | 12,136 | $45.9K | 0.06% | +12,136 | New |
| Alpine Global Management, LLC | 12,017 | $45.4K | 0.01% | +12,017 | New |
| Royal Bank of Canada | 11,874 | $45.0K | 0.00% | +24+0.2% | Added |
| Bank of Nova Scotia | 11,884 | $44.9K | 0.00% | +1,188+11.1% | Added |
| Fox Run Management, L.L.C. | 11,788 | $44.6K | 0.01% | +11,788 | New |
| HSBC Holdings PLC | 11,566 | $43.3K | 0.00% | −50,121−81.3% | Reduced |
| Vident Advisory, LLC | 10,862 | $41.1K | 0.00% | −4,710−30.2% | Reduced |
| Gsa Capital Partners LLP | 10,639 | $40.0K | 0.00% | +10,639 | New |
| R Squared Ltd | 6,370 | $24.1K | 0.02% | +6,370 | New |
| Russell Investments Group, Ltd. | 5,069 | $19.2K | 0.00% | −1,920−27.5% | Reduced |
| Point72 (DIFC) Ltd | 4,796 | $18.1K | 0.00% | +4,796 | New |
| US Bancorp | 4,000 | $15.1K | 0.00% | +4,000 | New |