Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 171
- −8 vs. Q4 2025
- Shares held
- 114.1M
- +7.64M (+7.2%) vs. Q4 2025
- Total value
- $1.59B
- +$299.6M (+23.3%) vs. Q4 2025
- New holders
- 28
- 63 more added
- Sold out
- 36
- 53 more reduced
1 institution that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 16,630,541 | $231.2M | 0.01% | +112,122+0.7% | Added |
| BlackRock, Inc. | 8,828,836 | $122.7M | 0.00% | −225,595−2.5% | Reduced |
| Perceptive Advisors LLC | 8,284,882 | $115.2M | 2.27% | 00.0% | Unchanged |
| TCG Crossover Management, LLC | 6,243,812 | $86.8M | 2.48% | 00.0% | Unchanged |
| Commodore Capital LP | 5,650,000 | $78.5M | 4.54% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 4,986,073 | $69.3M | 0.03% | +520,201+11.6% | Added |
| Saturn V Capital Management LLC | 4,349,885 | $60.5M | 10.95% | −146,602−3.3% | Reduced |
| Vanguard Capital Management LLC | 4,141,575 | $57.6M | 0.00% | +4,141,575 | New |
| Adage Capital Partners GP, L.L.C. | 3,560,764 | $49.5M | 0.08% | +783,709+28.2% | Added |
| First Light Asset Management, LLC | 3,190,645 | $44.3M | 3.97% | −164,894−4.9% | Reduced |
| Driehaus Capital Management LLC | 2,987,147 | $41.5M | 0.31% | −122,356−3.9% | Reduced |
| Goldman Sachs Group Inc | 2,625,991 | $36.5M | 0.00% | +12,770+0.5% | Added |
| State Street Corp | 2,363,161 | $32.8M | 0.00% | +293,277+14.2% | Added |
| Franklin Resources Inc | 2,261,569 | $31.4M | 0.01% | +1,061,473+88.4% | Added |
| Geode Capital Management, LLC | 2,210,932 | $30.7M | 0.00% | +45,398+2.1% | Added |
| Morgan Stanley | 2,175,547 | $30.2M | 0.00% | −184,277−7.8% | Reduced |
| Almitas Capital LLC | 2,122,597 | $29.5M | 6.67% | 00.0% | Unchanged |
| Great Point Partners LLC | 1,750,000 | $24.3M | 5.96% | 00.0% | Unchanged |
| Jones Hill Capital LP | 1,598,794 | $22.2M | 4.76% | +1,598,794 | New |
| 683 Capital Management, LLC | 1,530,000 | $21.3M | 1.97% | −120,000−7.3% | Reduced |
| Eventide Asset Management, LLC | 1,513,958 | $21.0M | 0.35% | +810+0.1% | Added |
| Bank of America Corp | 1,330,689 | $18.5M | 0.00% | −5,321−0.4% | Reduced |
| Deutsche Bank AG | 1,267,785 | $17.6M | 0.01% | −65,451−4.9% | Reduced |
| Siren, L.L.C. | 1,230,000 | $17.1M | 0.47% | +1,230,000 | New |
| Balyasny Asset Management LLC | 1,107,271 | $15.4M | 0.03% | +248,587+28.9% | Added |
| ADAR1 Capital Management, LLC | 1,000,604 | $13.9M | 0.84% | +110,248+12.4% | Added |
| Barclays PLC | 971,854 | $13.5M | 0.00% | +676,677+229.2% | Added |
| Vanguard Portfolio Management LLC | 944,781 | $13.1M | 0.00% | +944,781 | New |
| Dimensional Fund Advisors LP | 903,192 | $12.5M | 0.00% | +131,944+17.1% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 868,325 | $12.1M | 0.03% | −135,696−13.5% | Reduced |
| Woodline Partners LP | 845,800 | $11.8M | 0.04% | +3920.0% | Added |
| Boxer Capital Management, LLC | 800,000 | $11.1M | 1.46% | 00.0% | Unchanged |
| Northern Trust Corp | 779,908 | $10.8M | 0.00% | −157,856−16.8% | Reduced |
| Charles Schwab Investment Management Inc | 716,225 | $9.96M | 0.00% | +3,235+0.5% | Added |
| Qube Research & Technologies Ltd | 702,236 | $9.76M | 0.01% | +289,363+70.1% | Added |
| Logos Global Management LP | 700,000 | $9.73M | 0.50% | −250,000−26.3% | Reduced |
| StemPoint Capital LP | 669,685 | $9.31M | 1.79% | +104,545+18.5% | Added |
| Parkman Healthcare Partners LLC | 621,458 | $8.64M | 0.90% | +239,698+62.8% | Added |
| Jupiter Asset Management Ltd | 592,654 | $8.24M | 0.04% | +577,080+3,705.4% | Added |
| Vanguard Fiduciary Trust Co | 586,152 | $8.15M | 0.00% | +586,152 | New |
| Nantahala Capital Management, LLC | 535,684 | $7.45M | 0.46% | −300,000−35.9% | Reduced |
| Rock Springs Capital Management LP | 499,764 | $6.95M | 0.41% | 00.0% | Unchanged |
| Citadel Advisors LLC | 411,532 | $5.72M | 0.00% | +66,564+19.3% | Added |
| Federated Hermes, Inc. | 363,546 | $5.05M | 0.01% | −93,866−20.5% | Reduced |
| HighVista Strategies LLC | 352,085 | $4.89M | 1.35% | +113,273+47.4% | Added |
| Cormorant Asset Management, LP | 350,000 | $4.87M | 0.25% | −50,000−12.5% | Reduced |
| UBS Group AG | 324,319 | $4.51M | 0.00% | −219,004−40.3% | Reduced |
| Polygon Management Ltd. | 317,877 | $4.42M | 0.87% | +45,049+16.5% | Added |
| iA Global Asset Management Inc. | 304,786 | $4.24M | 0.06% | +304,786 | New |
| Nuveen, LLC | 264,897 | $3.68M | 0.00% | −19,051−6.7% | Reduced |
| Bank of New York Mellon Corp | 251,104 | $3.49M | 0.00% | +33,757+15.5% | Added |
| Wellington Management Group LLP | 241,552 | $3.36M | 0.00% | +15,770+7.0% | Added |
| SummitTX Capital, L.P. | 227,010 | $3.16M | 0.10% | +8,611+3.9% | Added |
| Aldebaran Capital, LLC | 197,892 | $2.75M | 2.10% | −616−0.3% | Reduced |
| Invesco Ltd. | 171,620 | $2.39M | 0.00% | −4,294−2.4% | Reduced |
| Two Sigma Investments, LP | 161,945 | $2.25M | 0.00% | −182,456−53.0% | Reduced |
| UBS Asset Management Americas Inc | 157,089 | $2.18M | 0.00% | +58,251+58.9% | Added |
| Acuta Capital Partners, LLC | 151,067 | $2.10M | 1.49% | −182,191−54.7% | Reduced |
| JPMorgan Chase & Co | 159,663 | $2.04M | 0.00% | +93,116+139.9% | Added |
| PFM Health Sciences, LP | 145,275 | $2.02M | 0.21% | +10,726+8.0% | Added |
| Falcon Edge Capital, LP | 142,336 | $1.98M | 0.25% | −175,342−55.2% | Reduced |
| Swiss National Bank | 130,300 | $1.81M | 0.00% | −31,400−19.4% | Reduced |
| Price T Rowe Associates Inc | 121,439 | $1.69M | 0.00% | +13,891+12.9% | Added |
| Squarepoint Ops LLC | 114,877 | $1.60M | 0.00% | +38,315+50.0% | Added |
| Elmind Capital, LP | 112,000 | $1.56M | 0.44% | 00.0% | Unchanged |
| Rhumbline Advisers | 108,467 | $1.51M | 0.00% | +9,193+9.3% | Added |
| Point72 Asset Management, L.P. | 106,535 | $1.48M | 0.00% | −228,465−68.2% | Reduced |
| Alps Advisors Inc | 89,983 | $1.25M | 0.01% | −189−0.2% | Reduced |
| SEI Investments Co | 85,279 | $1.19M | 0.00% | +32,423+61.3% | Added |
| Schonfeld Strategic Advisors LLC | 77,794 | $1.08M | 0.01% | +56,742+269.5% | Added |
| Wells Fargo & Company | 75,083 | $1.04M | 0.00% | −71,226−48.7% | Reduced |
| D. E. Shaw & Co., Inc. | 74,230 | $1.03M | 0.00% | +1,006+1.4% | Added |
| State of Wisconsin Investment Board | 72,061 | $1.00M | 0.00% | −12,083−14.4% | Reduced |
| Alliancebernstein L.P. | 80,800 | $976.1K | 0.00% | +9,300+13.0% | Added |
| California State Teachers Retirement System | 65,002 | $903.5K | 0.00% | −14,088−17.8% | Reduced |
| Walleye Capital LLC | 61,711 | $857.8K | 0.01% | +55,971+975.1% | Added |
| Russell Investments Group, Ltd. | 59,346 | $824.9K | 0.00% | −6,092−9.3% | Reduced |
| Legal & General Group Plc | 55,773 | $775.2K | 0.00% | −16,839−23.2% | Reduced |
| Campbell & CO Investment Adviser LLC | 54,422 | $756.5K | 0.04% | −24,341−30.9% | Reduced |
| EAM Investors, LLC | 53,256 | $740.3K | 0.09% | 00.0% | Unchanged |
| MetLife Investment Management | 51,587 | $717.1K | 0.00% | +1,933+3.9% | Added |
| Maven Securities LTD | 50,000 | $695.0K | 0.04% | +50,000 | New |
| Numerai GP LLC | 48,553 | $674.9K | 0.07% | −64,095−56.9% | Reduced |
| Vanguard Global Advisers, LLC | 47,851 | $665.1K | 0.00% | +47,851 | New |
| Vanguard Asset Management, Ltd | 43,283 | $601.6K | 0.00% | +43,283 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 42,553 | $591.5K | 0.00% | +1,387+3.4% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 40,790 | $567.0K | 0.00% | +4,913+13.7% | Added |
| Susquehanna International Group, LLP | 39,802 | $553.2K | 0.00% | −29,090−42.2% | Reduced |
| Manufacturers Life Insurance Company, The | 38,781 | $539.1K | 0.00% | +11,793+43.7% | Added |
| Optimize Financial Inc | 32,001 | $444.8K | 0.22% | +32,001 | New |
| Citigroup Inc | 31,782 | $441.8K | 0.00% | −6,250−16.4% | Reduced |
| Tudor Investment Corp Et Al | 31,334 | $435.5K | 0.00% | +8,932+39.9% | Added |
| AQR Capital Management LLC | 29,089 | $404.3K | 0.00% | +1,242+4.5% | Added |
| Integrated Quantitative Investments LLC | 27,234 | $378.6K | 0.07% | 00.0% | Unchanged |
| Guggenheim Capital LLC | 25,513 | $354.6K | 0.00% | +270+1.1% | Added |
| Intech Investment Management LLC | 24,921 | $346.4K | 0.00% | −7,085−22.1% | Reduced |
| JustInvest LLC | 24,072 | $334.6K | 0.00% | +3,232+15.5% | Added |
| Police & Firemen's Retirement System of New Jersey | 23,752 | $330.2K | 0.00% | 00.0% | Unchanged |
| State of New Jersey Common Pension Fund D | 22,519 | $313.0K | 0.00% | +22,519 | New |
| New York State Common Retirement Fund | 21,900 | $304.4K | 0.00% | 00.0% | Unchanged |