Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 131
- −5 vs. Q1 2025
- Shares held
- 81.7M
- +7.79M (+10.5%) vs. Q1 2025
- Total value
- $523.6M
- +$262.0M (+100.2%) vs. Q1 2025
- New holders
- 31
- 37 more added
- Sold out
- 36
- 37 more reduced
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Adage Capital Partners GP, L.L.C. | 8,800,000 | $56.4M | 0.10% | +3,102,395+54.5% | Added |
| Perceptive Advisors LLC | 7,902,365 | $50.7M | 1.90% | +28,017+0.4% | Added |
| TCG Crossover Management, LLC | 5,943,812 | $38.1M | 4.35% | 00.0% | Unchanged |
| BlackRock, Inc. | 5,510,189 | $35.3M | 0.00% | +3,122,780+130.8% | Added |
| Point72 Asset Management, L.P. | 4,536,266 | $29.1M | 0.07% | +3,619,300+394.7% | Added |
| Vanguard Group Inc | 4,498,028 | $28.8M | 0.00% | +381,516+9.3% | Added |
| Saturn V Capital Management LLC | 3,260,570 | $20.9M | 8.47% | +834,134+34.4% | Added |
| FMR LLC | 3,048,019 | $19.5M | 0.00% | +1,890,031+163.2% | Added |
| Nantahala Capital Management, LLC | 2,934,405 | $18.8M | 1.33% | 00.0% | Unchanged |
| 683 Capital Management, LLC | 2,160,000 | $13.8M | 1.40% | −251,400−10.4% | Reduced |
| Almitas Capital LLC | 2,122,597 | $13.6M | 3.43% | 00.0% | Unchanged |
| Great Point Partners LLC | 2,000,000 | $12.8M | 8.34% | +188,004+10.4% | Added |
| Geode Capital Management, LLC | 1,692,413 | $10.9M | 0.00% | +886,252+109.9% | Added |
| Millennium Management LLC | 1,512,058 | $9.69M | 0.01% | −1,569,795−50.9% | Reduced |
| Goldman Sachs Group Inc | 1,297,982 | $8.32M | 0.00% | −704,979−35.2% | Reduced |
| Driehaus Capital Management LLC | 1,264,997 | $8.11M | 0.06% | +1,264,997 | New |
| UBS Group AG | 1,253,344 | $8.03M | 0.00% | −135,083−9.7% | Reduced |
| Citadel Advisors LLC | 1,242,927 | $7.97M | 0.01% | −1,514,849−54.9% | Reduced |
| Boxer Capital Management, LLC | 1,225,000 | $7.85M | 3.95% | −525,000−30.0% | Reduced |
| ADAR1 Capital Management, LLC | 1,205,101 | $7.72M | 1.25% | −266,486−18.1% | Reduced |
| Woodline Partners LP | 1,200,290 | $7.69M | 0.04% | −409,157−25.4% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 1,154,485 | $7.40M | 0.03% | −45,206−3.8% | Reduced |
| State Street Corp | 1,008,909 | $6.47M | 0.00% | +747,126+285.4% | Added |
| Northern Trust Corp | 820,164 | $5.26M | 0.00% | +680,832+488.6% | Added |
| Standard Life Aberdeen plc | 738,657 | $4.73M | 0.01% | −1,691,701−69.6% | Reduced |
| PFM Health Sciences, LP | 732,256 | $4.69M | 0.41% | −101,879−12.2% | Reduced |
| Parkman Healthcare Partners LLC | 650,000 | $4.17M | 0.48% | +650,000 | New |
| Schonfeld Strategic Advisors LLC | 646,443 | $4.14M | 0.03% | +529,303+451.9% | Added |
| Deutsche Bank AG | 616,919 | $3.95M | 0.00% | +46,062+8.1% | Added |
| Charles Schwab Investment Management Inc | 588,411 | $3.77M | 0.00% | +215,558+57.8% | Added |
| Invesco Ltd. | 586,883 | $3.76M | 0.00% | +541,189+1,184.4% | Added |
| Acadian Asset Management LLC | 569,083 | $3.65M | 0.01% | +326,976+135.1% | Added |
| Two Sigma Investments, LP | 558,846 | $3.58M | 0.01% | −203,207−26.7% | Reduced |
| Rock Springs Capital Management LP | 499,764 | $3.20M | 0.20% | +156,536+45.6% | Added |
| Morgan Stanley | 486,893 | $3.12M | 0.00% | +12,475+2.6% | Added |
| Two Sigma Advisers, LP | 470,000 | $3.01M | 0.01% | −179,800−27.7% | Reduced |
| Bank of America Corp | 451,808 | $2.90M | 0.00% | −342,546−43.1% | Reduced |
| Qube Research & Technologies Ltd | 438,026 | $2.81M | 0.00% | −504,865−53.5% | Reduced |
| Renaissance Technologies LLC | 396,200 | $2.54M | 0.00% | −118,900−23.1% | Reduced |
| Dimensional Fund Advisors LP | 373,739 | $2.40M | 0.00% | +250,163+202.4% | Added |
| OrbiMed Advisors LLC | 313,200 | $2.01M | 0.05% | −34,800−10.0% | Reduced |
| Wellington Management Group LLP | 288,618 | $1.85M | 0.00% | −2,064−0.7% | Reduced |
| Falcon Edge Capital, LP | 275,842 | $1.77M | 0.19% | +88,531+47.3% | Added |
| J. Goldman & Co LP | 258,600 | $1.66M | 0.05% | +258,600 | New |
| Y-Intercept (Hong Kong) Ltd | 240,379 | $1.54M | 0.04% | +240,379 | New |
| Polygon Management Ltd. | 218,750 | $1.40M | 0.25% | +218,750 | New |
| Aldebaran Capital, LLC | 217,827 | $1.40M | 1.38% | −41,426−16.0% | Reduced |
| Federated Hermes, Inc. | 203,930 | $1.31M | 0.00% | +1,145+0.6% | Added |
| Jane Street Group, LLC | 186,986 | $1.20M | 0.00% | −144,199−43.5% | Reduced |
| Gsa Capital Partners LLP | 170,533 | $1.09M | 0.08% | +147,448+638.7% | Added |
| Nuveen, LLC | 155,536 | $997.0K | 0.00% | +155,536 | New |
| D. E. Shaw & Co., Inc. | 151,502 | $971.1K | 0.00% | −118,504−43.9% | Reduced |
| Bank of New York Mellon Corp | 150,837 | $966.9K | 0.00% | +150,837 | New |
| Bank of Montreal | 143,512 | $919.9K | 0.00% | 00.0% | Unchanged |
| American Century Companies Inc | 134,380 | $861.4K | 0.00% | +27,366+25.6% | Added |
| Barclays PLC | 130,274 | $835.1K | 0.00% | −7,131−5.2% | Reduced |
| Cubist Systematic Strategies, LLC | 123,242 | $790.0K | 0.01% | +40,112+48.3% | Added |
| Allostery Investments LP | 120,119 | $770.0K | 9.81% | −145,980−54.9% | Reduced |
| Susquehanna International Group, LLP | 110,846 | $710.5K | 0.00% | −1,360,079−92.5% | Reduced |
| Rhumbline Advisers | 100,576 | $644.7K | 0.00% | +100,576 | New |
| Tang Capital Management LLC | 100,000 | $641.0K | 0.03% | 00.0% | Unchanged |
| EAM Investors, LLC | 99,960 | $640.7K | 0.10% | +99,960 | New |
| Ameriprise Financial Inc | 95,219 | $610.4K | 0.00% | +82,414+643.6% | Added |
| Kennondale Capital Management LLC | 95,165 | $610.0K | 0.62% | −107,578−53.1% | Reduced |
| Price T Rowe Associates Inc | 91,392 | $586.0K | 0.00% | +33,692+58.4% | Added |
| JPMorgan Chase & Co | 87,989 | $564.0K | 0.00% | +33,920+62.7% | Added |
| Hennion & Walsh Asset Management, Inc. | 56,831 | $364.3K | 0.01% | −26,405−31.7% | Reduced |
| Cantor Fitzgerald, L. P. | 50,000 | $320.5K | 0.01% | −50,000−50.0% | Reduced |
| Mariner, LLC | 48,668 | $312.0K | 0.00% | −2,238−4.4% | Reduced |
| Jump Financial, LLC | 47,800 | $306.4K | 0.00% | +47,800 | New |
| Centiva Capital, LP | 45,464 | $291.4K | 0.02% | +17,242+61.1% | Added |
| MetLife Investment Management | 42,929 | $275.2K | 0.00% | +42,929 | New |
| Squarepoint Ops LLC | 40,643 | $260.5K | 0.00% | −35,206−46.4% | Reduced |
| Wells Fargo & Company | 38,101 | $244.2K | 0.00% | +37,801+12,600.3% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 37,987 | $243.5K | 0.00% | +37,987 | New |
| Intech Investment Management LLC | 36,315 | $232.8K | 0.00% | +36,315 | New |
| Guggenheim Capital LLC | 35,752 | $229.2K | 0.00% | −2,044−5.4% | Reduced |
| Graham Capital Management, L.P. | 34,153 | $218.9K | 0.01% | +34,153 | New |
| Citigroup Inc | 31,098 | $199.3K | 0.00% | −432,142−93.3% | Reduced |
| Alliancebernstein L.P. | 30,600 | $196.1K | 0.00% | +30,600 | New |
| Quadrature Capital Ltd | 29,430 | $188.4K | 0.00% | +16,686+130.9% | Added |
| Manufacturers Life Insurance Company, The | 25,999 | $166.7K | 0.00% | +25,999 | New |
| Group One Trading, L.P. | 25,856 | $165.7K | 0.01% | −17,378−40.2% | Reduced |
| Bridgeway Capital Management, LLC | 25,700 | $164.7K | 0.00% | −130,000−83.5% | Reduced |
| Los Angeles Capital Management LLC | 23,320 | $149.5K | 0.00% | +23,320 | New |
| New York State Common Retirement Fund | 21,900 | $140.4K | 0.00% | +21,900 | New |
| Parsons Capital Management Inc | 21,645 | $138.7K | 0.01% | 00.0% | Unchanged |
| JustInvest LLC | 21,123 | $135.4K | 0.00% | −633−2.9% | Reduced |
| Premier Path Wealth Partners, LLC | 20,265 | $129.9K | 0.02% | 00.0% | Unchanged |
| Marex Group plc | 20,000 | $128.2K | 0.00% | 00.0% | Unchanged |
| Brown Advisory Inc | 19,930 | $127.8K | 0.00% | 00.0% | Unchanged |
| Voya Investment Management LLC | 19,476 | $124.8K | 0.00% | +19,476 | New |
| China Universal Asset Management Co., Ltd. | 17,904 | $114.8K | 0.01% | +716+4.2% | Added |
| ProShare Advisors LLC | 17,551 | $112.5K | 0.00% | +17,551 | New |
| Police & Firemen's Retirement System of New Jersey | 15,992 | $102.5K | 0.00% | +15,992 | New |
| Prudential Financial Inc | 15,620 | $100.1K | 0.00% | +420+2.8% | Added |
| Royal Bank of Canada | 12,133 | $78.0K | 0.00% | +283+2.4% | Added |
| Tudor Investment Corp Et Al | 12,073 | $77.4K | 0.00% | −21,355−63.9% | Reduced |
| Valeo Financial Advisors, LLC | 10,000 | $64.1K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 7,467 | $47.9K | 0.00% | +664+9.8% | Added |