Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 206
- +37 vs. Q1 2026
- Shares held
- 115.0M
- +5.82M (+5.3%) vs. Q1 2026
- Total value
- $2.07B
- +$549.0M (+36.2%) vs. Q1 2026
- New holders
- 50
- 71 more added
- Sold out
- 13
- 60 more reduced
2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 16,727,909 | $300.4M | 0.01% | +97,368+0.6% | Added |
| BlackRock, Inc. | 8,827,085 | $158.5M | 0.00% | −1,7510.0% | Reduced |
| Perceptive Advisors LLC | 8,334,882 | $149.7M | 2.32% | +50,000+0.6% | Added |
| TCG Crossover Management, LLC | 6,243,812 | $112.1M | 2.70% | 00.0% | Unchanged |
| Commodore Capital LP | 5,650,000 | $101.5M | 6.04% | 00.0% | Unchanged |
| Jupiter Topco LLC | 5,236,102 | $94.0M | 0.04% | +5,236,102 | New |
| Saturn V Capital Management LLC | 4,624,101 | $83.0M | 11.91% | +274,216+6.3% | Added |
| Vanguard Capital Management LLC | 4,224,224 | $75.9M | 0.00% | +82,649+2.0% | Added |
| Morgan Stanley | 3,130,808 | $56.2M | 0.00% | +955,261+43.9% | Added |
| Driehaus Capital Management LLC | 3,036,970 | $54.5M | 0.32% | +49,823+1.7% | Added |
| First Light Asset Management, LLC | 3,023,256 | $54.3M | 3.30% | −167,389−5.2% | Reduced |
| Franklin Resources Inc | 2,950,225 | $53.0M | 0.01% | +688,656+30.5% | Added |
| Goldman Sachs Group Inc | 2,858,239 | $51.3M | 0.01% | +232,248+8.8% | Added |
| State Street Corp | 2,603,337 | $46.8M | 0.00% | +240,176+10.2% | Added |
| Geode Capital Management, LLC | 2,335,315 | $41.9M | 0.00% | +124,383+5.6% | Added |
| JPMorgan Chase & Co | 1,863,650 | $34.9M | 0.00% | +1,703,987+1,067.2% | Added |
| Adage Capital Partners GP, L.L.C. | 1,900,000 | $34.1M | 0.05% | −1,660,764−46.6% | Reduced |
| Siren, L.L.C. | 1,480,586 | $26.6M | 0.54% | +250,586+20.4% | Added |
| Eventide Asset Management, LLC | 1,327,536 | $23.8M | 0.32% | −186,422−12.3% | Reduced |
| 683 Capital Management, LLC | 1,279,512 | $23.0M | 2.11% | −250,488−16.4% | Reduced |
| Vanguard Portfolio Management LLC | 1,061,534 | $19.1M | 0.00% | +116,753+12.4% | Added |
| Alyeska Investment Group, L.P. | 1,053,015 | $18.9M | 0.05% | +1,053,015 | New |
| Almitas Capital LLC | 974,881 | $17.5M | 4.20% | −1,147,716−54.1% | Reduced |
| Dimensional Fund Advisors LP | 902,463 | $16.2M | 0.00% | −729−0.1% | Reduced |
| Jones Hill Capital LP | 894,058 | $16.1M | 3.41% | −704,736−44.1% | Reduced |
| Woodline Partners LP | 846,387 | $15.2M | 0.05% | +587+0.1% | Added |
| Northern Trust Corp | 831,740 | $14.9M | 0.00% | +51,832+6.6% | Added |
| Bank of America Corp | 821,841 | $14.8M | 0.00% | −508,848−38.2% | Reduced |
| Boxer Capital Management, LLC | 800,000 | $14.4M | 1.08% | 00.0% | Unchanged |
| Standard Life Aberdeen plc | 737,670 | $13.2M | 0.02% | +737,670 | New |
| Charles Schwab Investment Management Inc | 725,030 | $13.0M | 0.00% | +8,805+1.2% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 721,002 | $12.9M | 0.02% | −147,323−17.0% | Reduced |
| Great Point Partners LLC | 700,000 | $12.6M | 2.96% | −1,050,000−60.0% | Reduced |
| Balyasny Asset Management LLC | 684,974 | $12.3M | 0.02% | −422,297−38.1% | Reduced |
| Qube Research & Technologies Ltd | 681,389 | $12.2M | 0.01% | −20,847−3.0% | Reduced |
| Vanguard Fiduciary Trust Co | 623,078 | $11.2M | 0.00% | +36,926+6.3% | Added |
| Two Sigma Investments, LP | 593,435 | $10.7M | 0.01% | +431,490+266.4% | Added |
| Deutsche Bank AG | 557,937 | $10.0M | 0.00% | −709,848−56.0% | Reduced |
| Rock Springs Capital Management LP | 499,764 | $8.98M | 0.44% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 494,378 | $8.88M | 0.42% | −506,226−50.6% | Reduced |
| Nantahala Capital Management, LLC | 486,684 | $8.74M | 0.53% | −49,000−9.1% | Reduced |
| Federated Hermes, Inc. | 462,205 | $8.30M | 0.01% | +98,659+27.1% | Added |
| Nearwater Capital Markets, Ltd | 425,000 | $7.63M | 0.13% | +425,000 | New |
| Parkman Healthcare Partners LLC | 398,782 | $7.16M | 0.74% | −222,676−35.8% | Reduced |
| HighVista Strategies LLC | 386,080 | $6.93M | 1.58% | +33,995+9.7% | Added |
| StemPoint Capital LP | 384,304 | $6.90M | 1.19% | −285,381−42.6% | Reduced |
| Logos Global Management LP | 350,000 | $6.29M | 0.27% | −350,000−50.0% | Reduced |
| Trexquant Investment LP | 349,439 | $6.28M | 0.04% | +349,439 | New |
| Nuveen, LLC | 330,521 | $5.94M | 0.00% | +65,624+24.8% | Added |
| Ensign Peak Advisors, Inc | 305,441 | $5.49M | 0.01% | +305,441 | New |
| iA Global Asset Management Inc. | 303,786 | $5.46M | 0.06% | −1,000−0.3% | Reduced |
| Jane Street Group, LLC | 299,565 | $5.38M | 0.00% | +299,565 | New |
| Polygon Management Ltd. | 297,926 | $5.35M | 0.87% | −19,951−6.3% | Reduced |
| Jupiter Asset Management Ltd | 274,944 | $4.94M | 0.02% | −317,710−53.6% | Reduced |
| Bank of New York Mellon Corp | 274,435 | $4.93M | 0.00% | +23,331+9.3% | Added |
| UBS Group AG | 271,881 | $4.88M | 0.00% | −52,438−16.2% | Reduced |
| First Trust Advisors LP | 254,587 | $4.57M | 0.00% | +254,587 | New |
| SummitTX Capital, L.P. | 227,690 | $4.09M | 0.11% | +680+0.3% | Added |
| Wellington Management Group LLP | 212,842 | $3.82M | 0.00% | −28,710−11.9% | Reduced |
| Cormorant Asset Management, LP | 200,000 | $3.59M | 0.18% | −150,000−42.9% | Reduced |
| Aldebaran Capital, LLC | 195,892 | $3.52M | 2.64% | −2,000−1.0% | Reduced |
| Walleye Capital LLC | 186,588 | $3.35M | 0.02% | +124,877+202.4% | Added |
| OrbiMed Advisors LLC | 183,400 | $3.29M | 0.06% | +183,400 | New |
| Citadel Advisors LLC | 178,686 | $3.21M | 0.00% | −232,846−56.6% | Reduced |
| D. E. Shaw & Co., Inc. | 174,285 | $3.13M | 0.00% | +100,055+134.8% | Added |
| UBS Asset Management Americas Inc | 173,407 | $3.11M | 0.00% | +16,318+10.4% | Added |
| Acuta Capital Partners, LLC | 168,115 | $3.02M | 2.10% | +17,048+11.3% | Added |
| Norges Bank | 159,900 | $2.87M | 0.00% | +159,900 | New |
| Falcon Edge Capital, LP | 155,422 | $2.79M | 0.04% | +13,086+9.2% | Added |
| Price T Rowe Associates Inc | 145,133 | $2.61M | 0.00% | +23,694+19.5% | Added |
| Swiss National Bank | 144,200 | $2.59M | 0.00% | +13,900+10.7% | Added |
| PFM Health Sciences, LP | 143,700 | $2.58M | 0.22% | −1,575−1.1% | Reduced |
| Invesco Ltd. | 139,942 | $2.51M | 0.00% | −31,678−18.5% | Reduced |
| Wells Fargo & Company | 128,164 | $2.30M | 0.00% | +53,081+70.7% | Added |
| Ameriprise Financial Inc | 125,484 | $2.25M | 0.00% | +125,484 | New |
| Lighthouse Investment Partners, LLC | 122,909 | $2.21M | 0.07% | +122,909 | New |
| Ikarian Capital, LLC | 117,500 | $2.11M | 0.35% | +117,500 | New |
| Rhumbline Advisers | 112,920 | $2.03M | 0.00% | +4,453+4.1% | Added |
| Alps Advisors Inc | 112,447 | $2.02M | 0.01% | +22,464+25.0% | Added |
| Elmind Capital, LP | 112,000 | $2.01M | 0.51% | 00.0% | Unchanged |
| Campbell & CO Investment Adviser LLC | 100,963 | $1.81M | 0.10% | +46,541+85.5% | Added |
| Affinity Asset Advisors, LLC | 98,999 | $1.78M | 0.09% | +98,999 | New |
| Russell Investments Group, Ltd. | 87,574 | $1.57M | 0.00% | +28,228+47.6% | Added |
| Quantinno Capital Management LP | 80,850 | $1.45M | 0.00% | +80,850 | New |
| Alliancebernstein L.P. | 104,400 | $1.45M | 0.00% | +23,600+29.2% | Added |
| California State Teachers Retirement System | 79,872 | $1.43M | 0.00% | +14,870+22.9% | Added |
| 1492 Capital Management LLC | 79,751 | $1.43M | 0.42% | +79,751 | New |
| Citigroup Inc | 68,684 | $1.23M | 0.00% | +36,902+116.1% | Added |
| Schonfeld Strategic Advisors LLC | 66,804 | $1.20M | 0.01% | −10,990−14.1% | Reduced |
| State of Wisconsin Investment Board | 61,278 | $1.10M | 0.00% | −10,783−15.0% | Reduced |
| CI Private Wealth, LLC | 59,322 | $1.07M | 0.00% | +59,322 | New |
| Moody Aldrich Partners LLC | 57,802 | $1.04M | 0.19% | +57,802 | New |
| Vanguard Asset Management, Ltd | 56,948 | $1.02M | 0.00% | +13,665+31.6% | Added |
| Legal & General Group Plc | 56,477 | $1.01M | 0.00% | +704+1.3% | Added |
| Barclays PLC | 56,258 | $1.01M | 0.00% | −915,596−94.2% | Reduced |
| MetLife Investment Management | 55,700 | $1.00M | 0.00% | +4,113+8.0% | Added |
| SG Americas Securities, LLC | 55,321 | $994.0K | 0.00% | +55,321 | New |
| Hudson Bay Capital Management LP | 50,000 | $898.0K | 0.00% | +50,000 | New |
| Vanguard Global Advisers, LLC | 47,851 | $859.4K | 0.00% | 00.0% | Unchanged |
| Fox Run Management, L.L.C. | 44,817 | $804.9K | 0.13% | +44,817 | New |