Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 180
- +13 vs. Q3 2025
- Shares held
- 112.3M
- +2.61M (+2.4%) vs. Q3 2025
- Total value
- $1.36B
- −$134.1M (−9.0%) vs. Q3 2025
- New holders
- 40
- 72 more added
- Sold out
- 27
- 44 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 16,518,419 | $199.5M | 0.01% | +5,139,212+45.2% | Added |
| BlackRock, Inc. | 9,054,431 | $109.4M | 0.00% | +1,913,739+26.8% | Added |
| Perceptive Advisors LLC | 8,284,882 | $100.1M | 1.83% | −667,483−7.5% | Reduced |
| TCG Crossover Management, LLC | 6,243,812 | $75.4M | 2.50% | 00.0% | Unchanged |
| Vanguard Group Inc | 5,804,912 | $70.1M | 0.00% | +531,162+10.1% | Added |
| Commodore Capital LP | 5,650,000 | $68.3M | 4.54% | +1,574,522+38.6% | Added |
| Saturn V Capital Management LLC | 4,496,487 | $54.3M | 9.97% | −108,391−2.4% | Reduced |
| Janus Henderson Group PLC | 4,465,872 | $54.0M | 0.02% | +1,929,639+76.1% | Added |
| First Light Asset Management, LLC | 3,355,539 | $40.5M | 3.10% | −3430.0% | Reduced |
| Driehaus Capital Management LLC | 3,109,503 | $37.6M | 0.26% | +688,736+28.5% | Added |
| Adage Capital Partners GP, L.L.C. | 2,777,055 | $33.5M | 0.05% | −4,039,773−59.3% | Reduced |
| Goldman Sachs Group Inc | 2,613,221 | $31.6M | 0.00% | +602,588+30.0% | Added |
| Morgan Stanley | 2,359,824 | $28.5M | 0.00% | +409,523+21.0% | Added |
| Geode Capital Management, LLC | 2,165,534 | $26.2M | 0.00% | +353,495+19.5% | Added |
| Almitas Capital LLC | 2,122,597 | $25.6M | 5.65% | 00.0% | Unchanged |
| State Street Corp | 2,069,884 | $25.0M | 0.00% | +448,624+27.7% | Added |
| Great Point Partners LLC | 1,750,000 | $21.1M | 6.85% | +50,000+2.9% | Added |
| 683 Capital Management, LLC | 1,650,000 | $19.9M | 1.66% | −110,000−6.3% | Reduced |
| Eventide Asset Management, LLC | 1,513,148 | $18.3M | 0.29% | +6480.0% | Added |
| Bank of America Corp | 1,336,010 | $16.1M | 0.00% | +906,494+211.1% | Added |
| Deutsche Bank AG | 1,333,236 | $16.1M | 0.01% | −32,285−2.4% | Reduced |
| Franklin Resources Inc | 1,200,096 | $14.5M | 0.00% | +1,200,096 | New |
| Connor, Clark & Lunn Investment Management Ltd. | 1,004,021 | $12.1M | 0.03% | −102,987−9.3% | Reduced |
| Logos Global Management LP | 950,000 | $11.5M | 0.76% | −500,000−34.5% | Reduced |
| Northern Trust Corp | 937,764 | $11.3M | 0.00% | +115,527+14.1% | Added |
| ADAR1 Capital Management, LLC | 890,356 | $10.8M | 0.80% | +24,154+2.8% | Added |
| Balyasny Asset Management LLC | 858,684 | $10.4M | 0.02% | −617,618−41.8% | Reduced |
| Woodline Partners LP | 845,408 | $10.2M | 0.04% | +1180.0% | Added |
| Nantahala Capital Management, LLC | 835,684 | $10.1M | 0.60% | −100,000−10.7% | Reduced |
| Boxer Capital Management, LLC | 800,000 | $9.66M | 2.12% | −100,000−11.1% | Reduced |
| Dimensional Fund Advisors LP | 771,248 | $9.32M | 0.00% | +261,468+51.3% | Added |
| Charles Schwab Investment Management Inc | 712,990 | $8.61M | 0.00% | +67,805+10.5% | Added |
| StemPoint Capital LP | 565,140 | $6.83M | 1.17% | +288,256+104.1% | Added |
| UBS Group AG | 543,323 | $6.56M | 0.00% | −861,148−61.3% | Reduced |
| Sofinnova Investments, Inc. | 527,099 | $6.37M | 0.27% | +527,099 | New |
| Silverarc Capital Management, LLC | 506,242 | $6.12M | 0.88% | −193,758−27.7% | Reduced |
| Ameriprise Financial Inc | 502,366 | $6.07M | 0.00% | +368,858+276.3% | Added |
| Rock Springs Capital Management LP | 499,764 | $6.04M | 0.31% | 00.0% | Unchanged |
| Federated Hermes, Inc. | 457,412 | $5.53M | 0.01% | +245,033+115.4% | Added |
| Qube Research & Technologies Ltd | 412,873 | $4.99M | 0.01% | +245,767+147.1% | Added |
| Cormorant Asset Management, LP | 400,000 | $4.83M | 0.27% | −100,000−20.0% | Reduced |
| Parkman Healthcare Partners LLC | 381,760 | $4.61M | 0.44% | −197,414−34.1% | Reduced |
| Patient Square Capital LP | 350,000 | $4.23M | 0.91% | +33,688+10.7% | Added |
| Citadel Advisors LLC | 344,968 | $4.17M | 0.00% | +110,295+47.0% | Added |
| Two Sigma Investments, LP | 344,401 | $4.16M | 0.01% | +245,985+249.9% | Added |
| Point72 Asset Management, L.P. | 335,000 | $4.05M | 0.01% | −2,455,066−88.0% | Reduced |
| Acuta Capital Partners, LLC | 333,258 | $4.03M | 2.73% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 328,401 | $3.97M | 0.01% | +185,401+129.7% | Added |
| Falcon Edge Capital, LP | 317,678 | $3.84M | 0.47% | −9,634−2.9% | Reduced |
| Barclays PLC | 295,177 | $3.57M | 0.00% | −118,935−28.7% | Reduced |
| Nuveen, LLC | 283,948 | $3.43M | 0.00% | +123,529+77.0% | Added |
| Polygon Management Ltd. | 272,828 | $3.30M | 0.69% | +14,586+5.6% | Added |
| Jane Street Group, LLC | 263,235 | $3.18M | 0.00% | +263,235 | New |
| Acadian Asset Management LLC | 254,328 | $3.07M | 0.01% | −113,003−30.8% | Reduced |
| HighVista Strategies LLC | 238,812 | $2.88M | 0.74% | +238,812 | New |
| Wellington Management Group LLP | 225,782 | $2.73M | 0.00% | −10,415−4.4% | Reduced |
| SummitTX Capital, L.P. | 218,399 | $2.64M | 0.08% | +50,399+30.0% | Added |
| Bank of New York Mellon Corp | 217,347 | $2.63M | 0.00% | +34,391+18.8% | Added |
| Aldebaran Capital, LLC | 198,508 | $2.40M | 2.15% | −5,966−2.9% | Reduced |
| Renaissance Technologies LLC | 192,500 | $2.33M | 0.00% | +172,600+867.3% | Added |
| XTX Topco Ltd | 189,673 | $2.29M | 0.06% | +189,673 | New |
| Invesco Ltd. | 175,914 | $2.13M | 0.00% | −634,726−78.3% | Reduced |
| Swiss National Bank | 161,700 | $1.95M | 0.00% | +161,700 | New |
| Voloridge Investment Management, LLC | 153,363 | $1.85M | 0.01% | +153,363 | New |
| Wells Fargo & Company | 146,309 | $1.77M | 0.00% | +52,618+56.2% | Added |
| Atom Investors LP | 139,422 | $1.68M | 0.13% | +139,422 | New |
| Bank of Montreal | 138,525 | $1.67M | 0.00% | −5,227−3.6% | Reduced |
| PFM Health Sciences, LP | 134,549 | $1.63M | 0.16% | −301,607−69.2% | Reduced |
| Numerai GP LLC | 112,648 | $1.36M | 0.16% | +45,495+67.7% | Added |
| Elmind Capital, LP | 112,000 | $1.35M | 0.40% | +112,000 | New |
| Price T Rowe Associates Inc | 107,548 | $1.30M | 0.00% | +7,103+7.1% | Added |
| Rhumbline Advisers | 99,274 | $1.20M | 0.00% | +617+0.6% | Added |
| UBS Asset Management Americas Inc | 98,838 | $1.19M | 0.00% | +98,838 | New |
| Alps Advisors Inc | 90,172 | $1.09M | 0.01% | +90,172 | New |
| State of Wisconsin Investment Board | 84,144 | $1.02M | 0.00% | +70,269+506.4% | Added |
| California State Teachers Retirement System | 79,090 | $955.4K | 0.00% | +74,759+1,726.1% | Added |
| Campbell & CO Investment Adviser LLC | 78,763 | $951.5K | 0.05% | +54,281+221.7% | Added |
| Squarepoint Ops LLC | 76,562 | $924.9K | 0.00% | +76,562 | New |
| D. E. Shaw & Co., Inc. | 73,224 | $884.5K | 0.00% | +4,347+6.3% | Added |
| Legal & General Group Plc | 72,612 | $877.2K | 0.00% | +5,400+8.0% | Added |
| Alliancebernstein L.P. | 71,500 | $863.7K | 0.00% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 68,892 | $832.2K | 0.00% | +68,892 | New |
| JPMorgan Chase & Co | 66,547 | $803.9K | 0.00% | +30,703+85.7% | Added |
| Russell Investments Group, Ltd. | 65,438 | $790.5K | 0.00% | +10,032+18.1% | Added |
| Kennondale Capital Management LLC | 53,423 | $645.4K | 0.47% | −55,192−50.8% | Reduced |
| EAM Investors, LLC | 53,256 | $643.3K | 0.07% | −21,855−29.1% | Reduced |
| SEI Investments Co | 52,856 | $638.5K | 0.00% | +52,856 | New |
| MetLife Investment Management | 49,654 | $599.8K | 0.00% | +6,725+15.7% | Added |
| Trexquant Investment LP | 48,112 | $581.2K | 0.01% | −174,764−78.4% | Reduced |
| Millennium Management LLC | 46,455 | $561.2K | 0.00% | −371,316−88.9% | Reduced |
| Mariner, LLC | 46,342 | $559.9K | 0.00% | −1,685−3.5% | Reduced |
| PSP Research LLC | 44,223 | $534.2K | 0.47% | +44,223 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 41,166 | $497.3K | 0.00% | +9,167+28.6% | Added |
| Citigroup Inc | 38,032 | $459.4K | 0.00% | −51−0.1% | Reduced |
| Gsa Capital Partners LLP | 36,758 | $444.0K | 0.04% | −15,349−29.5% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 35,877 | $433.4K | 0.00% | +33,971+1,782.3% | Added |
| Fox Run Management, L.L.C. | 35,409 | $427.7K | 0.07% | +35,409 | New |
| Intech Investment Management LLC | 32,006 | $386.6K | 0.00% | +12,512+64.2% | Added |
| Persistent Asset Partners Ltd | 31,147 | $376.3K | 0.18% | +8,234+35.9% | Added |
| Headlands Technologies LLC | 30,543 | $369.0K | 0.03% | +30,543 | New |