Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 180
- +13 vs. Q3 2025
- Shares held
- 112.3M
- +2.61M (+2.4%) vs. Q3 2025
- Total value
- $1.36B
- −$134.1M (−9.0%) vs. Q3 2025
- New holders
- 40
- 72 more added
- Sold out
- 27
- 44 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| SBI Securities Co., Ltd. | 1 | $12 | 0.00% | −1,250−99.9% | Reduced |
| IFP Advisors, Inc | 1 | $12 | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 12 | $145 | 0.00% | 00.0% | Unchanged |
| Essential Partners LLC | 17 | $205 | 0.00% | +1+6.3% | Added |
| Farther Finance Advisors, LLC | 20 | $242 | 0.00% | 00.0% | Unchanged |
| Financial Consulate, Inc | 25 | $302 | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 25 | $302 | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 30 | $362 | 0.00% | 00.0% | Unchanged |
| Larson Financial Group LLC | 41 | $495 | 0.00% | +41 | New |
| Catherine Avery Investment Management LLC | 87 | $1.05K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 90 | $1.09K | 0.00% | 00.0% | Unchanged |
| J.Safra Asset Management Corp | 123 | $1.49K | 0.00% | +123 | New |
| Massmutual Trust Co FSB | 153 | $1.85K | 0.00% | −87−36.3% | Reduced |
| Evolution Wealth Management Inc. | 165 | $1.99K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 266 | $3.00K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 249 | $3.01K | 0.00% | +24+10.7% | Added |
| Rockefeller Capital Management L.P. | 261 | $3.15K | 0.00% | +256+5,120.0% | Added |
| GAMMA Investing LLC | 267 | $3.23K | 0.00% | +142+113.6% | Added |
| UMA Financial Services, Inc. | 274 | $3.31K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 438 | $5.29K | 0.00% | −47−9.7% | Reduced |
| Dunhill Financial, LLC | 600 | $7.25K | 0.00% | 00.0% | Unchanged |
| Westfuller Advisors, LLC | 819 | $9.89K | 0.00% | +819 | New |
| Nisa Investment Advisors, LLC | 922 | $11.1K | 0.00% | +637+223.5% | Added |
| Los Angeles Capital Management LLC | 852 | $12.0K | 0.00% | +852 | New |
| CWM, LLC | 1,193 | $14.0K | 0.00% | +7+0.6% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,315 | $16.0K | 0.00% | +1,315 | New |
| State of Wyoming | 1,381 | $16.7K | 0.00% | +1,381 | New |
| Steward Partners Investment Advisory, LLC | 1,500 | $18.1K | 0.00% | 00.0% | Unchanged |
| Sterling Capital Management LLC | 1,627 | $19.7K | 0.00% | +418+34.6% | Added |
| US Bancorp | 2,000 | $24.2K | 0.00% | −2,000−50.0% | Reduced |
| Meeder Asset Management Inc | 2,099 | $25.4K | 0.00% | +2,099 | New |
| GF Fund Management Co. Ltd. | 2,158 | $26.1K | 0.00% | +240+12.5% | Added |
| Loring Wolcott & Coolidge Fiduciary Advisors LLP | 1,803 | $27.9K | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 2,550 | $30.8K | 0.00% | +306+13.6% | Added |
| Amalgamated Bank | 2,788 | $34.0K | 0.00% | +419+17.7% | Added |
| Walleye Trading LLC | 2,825 | $34.1K | 0.00% | +2,825 | New |
| STRS Ohio | 3,400 | $41.1K | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 3,727 | $45.0K | 0.00% | +3,727 | New |
| Caitong International Asset Management Co., Ltd | 3,859 | $46.6K | 0.01% | +3,493+954.4% | Added |
| T. Rowe Price Investment Management, Inc. | 4,517 | $55.0K | 0.00% | −1,193,547−99.6% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 5,337 | $64.5K | 0.00% | +1,890+54.8% | Added |
| Walleye Capital LLC | 5,740 | $69.3K | 0.00% | +5,740 | New |
| Quest Partners LLC | 7,195 | $86.9K | 0.00% | −6,441−47.2% | Reduced |
| Ameritas Investment Partners, Inc. | 7,203 | $87.0K | 0.00% | +1,409+24.3% | Added |
| Tower Research Capital LLC (TRC) | 8,095 | $97.8K | 0.00% | +1,505+22.8% | Added |
| ACT Capital Management, LLC | 9,000 | $108.7K | 0.09% | +9,000 | New |
| EntryPoint Capital, LLC | 10,487 | $126.7K | 0.05% | −6,679−38.9% | Reduced |
| Victory Capital Management Inc | 10,552 | $127.5K | 0.00% | +10,552 | New |
| Seven Fleet Capital Management LP | 11,571 | $139.8K | 0.09% | +11,571 | New |
| Teacher Retirement System of Texas | 12,174 | $147.1K | 0.00% | +12,174 | New |
| Landscape Capital Management, L.L.C. | 12,226 | $147.7K | 0.01% | +1,825+17.5% | Added |
| Valeo Financial Advisors, LLC | 15,000 | $181.2K | 0.00% | +5,000+50.0% | Added |
| Voya Investment Management LLC | 15,247 | $184.2K | 0.00% | +2,257+17.4% | Added |
| Quadrature Capital Ltd | 15,465 | $186.8K | 0.00% | −12,821−45.3% | Reduced |
| Royal Bank of Canada | 15,643 | $188.0K | 0.00% | −77,369−83.2% | Reduced |
| Jupiter Asset Management Ltd | 15,574 | $188.1K | 0.00% | +15,574 | New |
| KLP Kapitalforvaltning AS | 17,400 | $210.2K | 0.00% | +17,400 | New |
| Rafferty Asset Management, LLC | 17,673 | $213.5K | 0.00% | +17,673 | New |
| China Universal Asset Management Co., Ltd. | 17,895 | $216.2K | 0.02% | +2,265+14.5% | Added |
| Engineers Gate Manager LP | 18,358 | $221.8K | 0.00% | +18,358 | New |
| Brown Advisory Inc | 19,930 | $240.8K | 0.00% | 00.0% | Unchanged |
| Premier Path Wealth Partners, LLC | 20,265 | $244.8K | 0.03% | 00.0% | Unchanged |
| Virtus Investment Advisers, Inc. | 20,307 | $245.3K | 0.07% | +20,307 | New |
| Profund Advisors LLC | 20,589 | $248.7K | 0.01% | +7,171+53.4% | Added |
| JustInvest LLC | 20,840 | $251.7K | 0.00% | −261−1.2% | Reduced |
| SG Americas Securities, LLC | 20,846 | $252.0K | 0.00% | +9,027+76.4% | Added |
| Schonfeld Strategic Advisors LLC | 21,052 | $254.3K | 0.00% | −22,585−51.8% | Reduced |
| ProShare Advisors LLC | 21,068 | $254.5K | 0.00% | +6,030+40.1% | Added |
| Parsons Capital Management Inc | 21,645 | $261.5K | 0.01% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 21,900 | $264.6K | 0.00% | 00.0% | Unchanged |
| Tudor Investment Corp Et Al | 22,402 | $270.6K | 0.00% | +22,402 | New |
| Arizona State Retirement System | 22,914 | $276.8K | 0.00% | +22,914 | New |
| Police & Firemen's Retirement System of New Jersey | 23,752 | $286.9K | 0.00% | +4,490+23.3% | Added |
| Aquatic Capital Management LLC | 24,352 | $294.2K | 0.01% | +24,352 | New |
| BNP Paribas Arbitrage, SA | 25,201 | $304.4K | 0.00% | +10,592+72.5% | Added |
| Guggenheim Capital LLC | 25,243 | $304.9K | 0.00% | +344+1.4% | Added |
| Manufacturers Life Insurance Company, The | 26,988 | $326.0K | 0.00% | +3,198+13.4% | Added |
| Integrated Quantitative Investments LLC | 27,234 | $329.0K | 0.07% | +27,234 | New |
| AQR Capital Management LLC | 27,847 | $336.4K | 0.00% | −45,793−62.2% | Reduced |
| Verition Fund Management LLC | 29,487 | $356.2K | 0.00% | −34,409−53.9% | Reduced |
| Headlands Technologies LLC | 30,543 | $369.0K | 0.03% | +30,543 | New |
| Persistent Asset Partners Ltd | 31,147 | $376.3K | 0.18% | +8,234+35.9% | Added |
| Intech Investment Management LLC | 32,006 | $386.6K | 0.00% | +12,512+64.2% | Added |
| Fox Run Management, L.L.C. | 35,409 | $427.7K | 0.07% | +35,409 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 35,877 | $433.4K | 0.00% | +33,971+1,782.3% | Added |
| Gsa Capital Partners LLP | 36,758 | $444.0K | 0.04% | −15,349−29.5% | Reduced |
| Citigroup Inc | 38,032 | $459.4K | 0.00% | −51−0.1% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 41,166 | $497.3K | 0.00% | +9,167+28.6% | Added |
| PSP Research LLC | 44,223 | $534.2K | 0.47% | +44,223 | New |
| Mariner, LLC | 46,342 | $559.9K | 0.00% | −1,685−3.5% | Reduced |
| Millennium Management LLC | 46,455 | $561.2K | 0.00% | −371,316−88.9% | Reduced |
| Trexquant Investment LP | 48,112 | $581.2K | 0.01% | −174,764−78.4% | Reduced |
| MetLife Investment Management | 49,654 | $599.8K | 0.00% | +6,725+15.7% | Added |
| SEI Investments Co | 52,856 | $638.5K | 0.00% | +52,856 | New |
| EAM Investors, LLC | 53,256 | $643.3K | 0.07% | −21,855−29.1% | Reduced |
| Kennondale Capital Management LLC | 53,423 | $645.4K | 0.47% | −55,192−50.8% | Reduced |
| Russell Investments Group, Ltd. | 65,438 | $790.5K | 0.00% | +10,032+18.1% | Added |
| JPMorgan Chase & Co | 66,547 | $803.9K | 0.00% | +30,703+85.7% | Added |
| Susquehanna International Group, LLP | 68,892 | $832.2K | 0.00% | +68,892 | New |
| Alliancebernstein L.P. | 71,500 | $863.7K | 0.00% | 00.0% | Unchanged |