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Amylyx Pharmaceuticals, Inc.

AMLX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001658551

In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.

Q4 2025 vs. Q3 2025

How the institutions holding Amylyx Pharmaceuticals, Inc. changed between Q3 2025 and Q4 2025.

All holders in Q4 2025All holders in Q3 2025

13F holders of AMLX: Q3 2025 compared with Q4 2025
MeasureQ3 2025Of which not filed for Q4 2025Q4 2025Change
Holders1692180+13
Shares109.7M11.6K112.3M+2.61M (+2.4%)
Value$1.49B$157.2K$1.36B−$134.1M (−9.0%)

2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so the changes leave them out.

New holders (40)

Institutions that held Amylyx Pharmaceuticals, Inc. at the end of Q4 2025 but not at the end of Q3 2025.

Institutions new to AMLX in Q4 2025
InstitutionSharesValue% of portfolio
Franklin Resources Inc1,200,096$14.5M0.00%
Sofinnova Investments, Inc.527,099$6.37M0.27%
Jane Street Group, LLC263,235$3.18M0.00%
HighVista Strategies LLC238,812$2.88M0.74%
XTX Topco Ltd189,673$2.29M0.06%
Swiss National Bank161,700$1.95M0.00%
Voloridge Investment Management, LLC153,363$1.85M0.01%
Atom Investors LP139,422$1.68M0.13%
Elmind Capital, LP112,000$1.35M0.40%
UBS Asset Management Americas Inc98,838$1.19M0.00%
Alps Advisors Inc90,172$1.09M0.01%
Squarepoint Ops LLC76,562$924.9K0.00%
Susquehanna International Group, LLP68,892$832.2K0.00%
SEI Investments Co52,856$638.5K0.00%
PSP Research LLC44,223$534.2K0.47%
Fox Run Management, L.L.C.35,409$427.7K0.07%
Headlands Technologies LLC30,543$369.0K0.03%
Integrated Quantitative Investments LLC27,234$329.0K0.07%
Aquatic Capital Management LLC24,352$294.2K0.01%
Arizona State Retirement System22,914$276.8K0.00%
Tudor Investment Corp Et Al22,402$270.6K0.00%
Virtus Investment Advisers, Inc.20,307$245.3K0.07%
Engineers Gate Manager LP18,358$221.8K0.00%
Rafferty Asset Management, LLC17,673$213.5K0.00%
KLP Kapitalforvaltning AS17,400$210.2K0.00%
Jupiter Asset Management Ltd15,574$188.1K0.00%
Teacher Retirement System of Texas12,174$147.1K0.00%
Seven Fleet Capital Management LP11,571$139.8K0.09%
Victory Capital Management Inc10,552$127.5K0.00%
ACT Capital Management, LLC9,000$108.7K0.09%
Walleye Capital LLC5,740$69.3K0.00%
Simplex Trading, LLC3,727$45.0K0.00%
Walleye Trading LLC2,825$34.1K0.00%
Meeder Asset Management Inc2,099$25.4K0.00%
State of Wyoming1,381$16.7K0.00%
BNP PARIBAS ASSET MANAGEMENT Holding S.A.1,315$16.0K0.00%
Los Angeles Capital Management LLC852$12.0K0.00%
Westfuller Advisors, LLC819$9.89K0.00%
J.Safra Asset Management Corp123$1.49K0.00%
Larson Financial Group LLC41$4950.00%

Sold out (27)

Institutions that held Amylyx Pharmaceuticals, Inc. at the end of Q3 2025 and filed for Q4 2025 without it.

Not filed for Q4 2025 yet (2)

Institutions that held Amylyx Pharmaceuticals, Inc. at the end of Q3 2025 and haven't filed a 13F for Q4 2025. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding AMLX in Q3 2025 that haven't filed for Q4 2025
InstitutionShares, Q3 2025Value, Q3 2025
Point72 (DIFC) Ltd5,967$81.1K
Cubist Systematic Strategies, LLC5,603$76.1K