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Amylyx Pharmaceuticals, Inc.

AMLX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001658551

In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 9 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.

Holders of 5% or more of AMLX

Holders whose latest Schedule 13D or 13G filing reports 5% or more of Amylyx Pharmaceuticals, Inc., largest stake first. The change is against the holder's previous filing.

Holders of 5% or more of AMLX
HolderLatest formStakeChangeFirst filedLatest filingFiling
FMR LLC13G/A15.00%16.5M shares+4.30 ppfrom 10.70%Oct 7, 20252 filingsFeb 5, 2026SEC
Perceptive Advisors LLC13G/A7.50%8.28M shares−0.70 ppfrom 8.20%Jun 21, 20228 filingsMay 15, 2026SEC
BlackRock, Inc.13G/A7.10%7.78M shares+1.60 ppfrom 5.50%Jul 17, 20252 filingsJan 21, 2026SEC
TCG Crossover GP II, LLC13G/A5.70%6.24M shares–Aug 26, 20242 filingsFeb 17, 2026SEC
Commodore Capital LP13G5.10%5.65M sharesNewNov 17, 20251 filingNov 17, 2025SEC

Stakes are as of each holder's latest filing. Holders whose last filing was in the old format (before December 18, 2024) have no stake on record and are not listed, and after an acquisition or delisting holders usually stop filing.

13D and 13G filings

49 Schedule 13D and 13G filings on Amylyx Pharmaceuticals, Inc., newest first, including old-format filings without a stake.

Schedule 13D and 13G filings on AMLX
Filed (ET)FilerFormStakeChangeEvent dateFiling
May 15, 20264:00 PM ETPerceptive Advisors LLCand 2 others13G/A7.50%8.28M shares−0.70 ppfrom 8.20%Mar 31, 2026SEC
Mar 26, 20263:41 PM ETVanguard Group Inc13G/A0.00%0 shares−5.28 ppfrom 5.28%Below 5%Mar 13, 2026SEC
Feb 17, 20264:22 PM ETTCG Crossover GP II, LLCand 2 others13G/A5.70%6.24M shares–Dec 31, 2025SEC
Feb 12, 20269:09 AM ETAdage Capital Management, L.P.and 2 others13G/A2.53%2.78M shares−3.86 ppfrom 6.39%Below 5%Dec 31, 2025SEC
Feb 5, 20261:16 PM ETFMR LLCand 1 other13G/A15.00%16.5M shares+4.30 ppfrom 10.70%Dec 31, 2025SEC
Jan 30, 20261:27 PM ETVanguard Group Inc13G5.28%5.80M shares+0.34 ppfrom 4.94%Dec 31, 2025SEC
Jan 21, 202612:30 PM ETBlackRock, Inc.13G/A7.10%7.78M shares+1.60 ppfrom 5.50%Dec 31, 2025SEC
Nov 17, 20255:39 PM ETCommodore Capital LPand 3 others13G5.10%5.65M sharesNewNov 10, 2025SEC
Nov 14, 20254:10 PM ETPoint72 Asset Management, L.P.and 2 others13G/A2.60%2.80M shares−2.70 ppfrom 5.30%Below 5%Sep 30, 2025SEC
Nov 14, 20254:00 PM ETPerceptive Advisors LLCand 2 others13G/A8.20%8.95M shares−0.60 ppfrom 8.80%Sep 30, 2025SEC
Nov 13, 20259:05 AM ETAdage Capital Management, L.P.and 2 others13G/A6.39%6.82M shares−3.48 ppfrom 9.87%Sep 30, 2025SEC
Oct 30, 20252:37 PM ETVanguard Group Inc13G/A4.94%5.27M shares−0.10 ppfrom 5.04%Below 5%Sep 30, 2025SEC
Oct 7, 20253:49 PM ETFMR LLCand 1 other13G10.70%11.4M sharesNewSep 30, 2025SEC
Aug 12, 20259:07 AM ETAdage Capital Management, L.P.and 2 others13G/A9.87%8.80M shares+3.44 ppfrom 6.43%Jun 30, 2025SEC
Jul 29, 202511:21 AM ETVanguard Group Inc13G5.04%4.50M shares–Jun 30, 2025SEC
Jul 17, 20257:44 PM ETBlackRock, Inc.13G5.50%4.92M sharesNewJun 30, 2025SEC
Jun 25, 20255:24 PM ETPoint72 Asset Management, L.P.and 2 others13G5.30%4.72M shares+4.10 ppfrom 1.20%Jun 24, 2025SEC
May 15, 20254:30 PM ETPerceptive Advisors LLCand 2 others13G/A8.80%7.87M shares+0.90 ppfrom 7.90%Mar 31, 2025SEC
May 15, 20253:52 PM ETPoint72 Asset Management, L.P.and 2 others13G/A1.20%1.05M shares−4.40 ppfrom 5.60%Below 5%Mar 31, 2025SEC
May 12, 20259:05 AM ETAdage Capital Management, L.P.and 2 others13G6.43%5.70M sharesNewMar 31, 2025SEC
Feb 14, 20254:30 PM ETPanacea Innovation Ltdand 3 others13G/A2.60%2.20M shares–Below 5%Dec 31, 2024SEC
Feb 14, 20254:15 PM ETPerceptive Advisors LLCand 2 others13G/A7.90%6.77M shares–Dec 31, 2024SEC
Jan 14, 20254:53 PM ETPoint72 Asset Management, L.P.and 2 others13G5.60%4.82M shares–Jan 13, 2025SEC
Nov 12, 2024Vanguard Group Inc13G/AOld format–––SEC
Nov 4, 2024Vanguard Group Inc13GOld format–––SEC
Oct 25, 2024Perceptive Advisors LLC13GOld format–––SEC
Aug 26, 2024TCG Crossover GP II, LLC13GOld format–New–SEC
Jul 8, 20244:32 PM ETBlackRock Inc.13G/AOld format–––SEC
Mar 11, 2024Panacea Innovation Ltd13GOld format–New–SEC
Feb 14, 2024Perceptive Advisors LLC13G/AOld format–––SEC
Feb 14, 2024Viking Global Investors LPSuperinvestorViking Global Investors13G/AOld format–––SEC
Feb 14, 2024Point72 Asset Management, L.P.13G/AOld format–––SEC
Feb 13, 2024Vanguard Group Inc13G/AOld format–––SEC
Jan 29, 20245:25 PM ETBlackRock Inc.13GOld format–New–SEC
Dec 11, 2023Point72 Asset Management, L.P.13GOld format–New–SEC
Oct 4, 2023Morningside Venture Investments Ltd13D/AOld format–––SEC
Aug 17, 2023Morningside Venture Investments Ltd13D/AOld format–––SEC
Jun 9, 20233:54 PM ETGoldman Sachs Group Inc13GOld format–New–SEC
Apr 3, 2023Morningside Venture Investments Ltd13D/AOld format–––SEC
Feb 14, 2023Perceptive Advisors LLC13G/AOld format–––SEC
Feb 14, 2023Viking Global Investors LPSuperinvestorViking Global Investors13G/AOld format–––SEC
Feb 13, 20232:27 PM ETBlackRock Inc.13GOld format–New–SEC
Feb 9, 2023Vanguard Group Inc13GOld format–New–SEC
Sep 30, 2022Morningside Venture Investments Ltd13D/AOld format–––SEC
Sep 21, 2022Millennium Management LLC13GOld format–New–SEC
Sep 12, 2022Viking Global Investors LPSuperinvestorViking Global Investors13G/AOld format–––SEC
Jun 21, 2022Perceptive Advisors LLC13GOld format–New–SEC
Jan 25, 2022Morningside Venture Investments Ltd13DOld format–New–SEC
Jan 21, 2022Viking Global Investors LPSuperinvestorViking Global Investors13GOld format–New–SEC

Form 144: proposed insider sales

39 notices from officers, directors and other affiliates planning to sell Amylyx Pharmaceuticals, Inc. shares, newest first.

Form 144 notices for AMLX
Filed (ET)SellerShares to sellMarket valuePlanned saleBrokerFiling
Nov 9, 20264:36 PM ETJoshua Barry CohenDirector · Officer100.0K$2.95MNov 9, 202610b5-1Morgan Stanley Smith Barney LLC Executive Financial ServicesSEC
Nov 9, 20264:36 PM ETJames M FratesOfficer40.0K$1.18MNov 9, 202610b5-1Morgan Stanley Smith Barney LLC Executive Financial ServicesSEC
Nov 9, 20264:36 PM ETJustin KleeDirector · Officer100.0K$2.95MNov 9, 202610b5-1Morgan Stanley Smith Barney LLC Executive Financial ServicesSEC
Oct 5, 20264:38 PM ETGeorge MilneDirector100.0K$2.78MOct 5, 202610b5-1Morgan Stanley Smith Barney LLC Executive Financial ServicesSEC
Sep 11, 20264:01 PM ETKlee Justin B.Officer · Director30.5K$980.3KSep 10, 2026Morgan Stanley Smith Barney LLCSEC
Sep 11, 20264:01 PM ETFrates James MOfficer10.8K$349.8KSep 10, 2026Morgan Stanley Smith Barney LLCSEC
Sep 11, 20264:01 PM ETBedrosian Camille LOfficer10.0K$324.9KSep 10, 2026Morgan Stanley Smith Barney LLCSEC
Sep 11, 20264:01 PM ETMazzariello GinaOfficer9.54K$309.5KSep 10, 2026Morgan Stanley Smith Barney LLCSEC
Sep 11, 20264:01 PM ETCohen Joshua BOfficer · Director30.5K$980.5KSep 10, 2026Morgan Stanley Smith Barney LLCSEC
Jul 9, 20264:26 PM ETGina MazzarielloOfficer30.0K$536.4KJul 9, 202610b5-1Morgan Stanley Smith Barney LLC Executive Financial ServicesSEC
Mar 2, 20264:30 PM ETKlee Justin B.Officer · Director29.3K$423.8KMar 2, 2026Morgan Stanley Smith Barney LLCSEC
Mar 2, 20264:30 PM ETBedrosian Camille LOfficer6.46K$94.2KMar 2, 2026Morgan Stanley Smith Barney LLCSEC
Mar 2, 20264:30 PM ETFrates James MOfficer7.91K$114.9KMar 2, 2026Morgan Stanley Smith Barney LLCSEC
Mar 2, 20264:30 PM ETMazzariello GinaOfficer6.84K$99.4KMar 2, 2026Morgan Stanley Smith Barney LLCSEC
Mar 2, 20264:30 PM ETCohen Joshua BOfficer · Director29.3K$424.1KMar 2, 2026Morgan Stanley Smith Barney LLCSEC
Feb 23, 20264:25 PM ETMazzariello GinaOfficer3.42K$48.4KFeb 23, 2026Morgan Stanley Smith Barney LLCSEC
Feb 2, 20264:10 PM ETCohen Joshua BOfficer · Director15.5K$227.6KFeb 2, 2026Morgan Stanley Smith Barney LLCSEC
Feb 2, 20264:10 PM ETKlee Justin B.Officer · Director15.5K$227.6KFeb 2, 2026Morgan Stanley Smith Barney LLCSEC
Feb 2, 20264:10 PM ETMazzariello GinaOfficer3.45K$50.5KFeb 2, 2026Morgan Stanley Smith Barney LLCSEC
Feb 2, 20264:10 PM ETFrates James MOfficer3.56K$52.1KFeb 2, 2026Morgan Stanley Smith Barney LLCSEC
Jan 16, 20264:05 PM ETJustin KleeDirector · Officer2.00K$27.0KJan 16, 2026Morgan Stanley Smith Barney LLC Executive Financial ServicesSEC
Jan 16, 20264:03 PM ETJoshua CohenDirector · Officer1.97K$26.7KJan 16, 2026Morgan Stanley Smith Barney LLC Executive Financial ServicesSEC
Jan 15, 20264:17 PM ETJoshua CohenDirector · Officer136.2K$1.92MJan 15, 2026Morgan Stanley Smith Barney LLC Executive Financial ServicesSEC
Jan 15, 20264:14 PM ETJustin KleeDirector · Officer136.2K$1.92MJan 15, 2026Morgan Stanley Smith Barney LLC Executive Financial ServicesSEC
Jan 6, 20264:05 PM ETFrates James MOfficer3.33K$37.0KJan 6, 2026Morgan Stanley Smith Barney LLCSEC

Showing the latest 25. See the AMLX notices from the last 12 months