Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 169
- +38 vs. Q2 2025
- Shares held
- 109.7M
- +28.0M (+34.3%) vs. Q2 2025
- Total value
- $1.49B
- +$967.5M (+184.8%) vs. Q2 2025
- New holders
- 57
- 44 more added
- Sold out
- 19
- 48 more reduced
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 11,379,207 | $154.6M | 0.01% | +8,331,188+273.3% | Added |
| Perceptive Advisors LLC | 8,952,365 | $121.7M | 3.52% | +1,050,000+13.3% | Added |
| BlackRock, Inc. | 7,140,692 | $97.0M | 0.00% | +1,630,503+29.6% | Added |
| Adage Capital Partners GP, L.L.C. | 6,816,828 | $92.6M | 0.15% | −1,983,172−22.5% | Reduced |
| TCG Crossover Management, LLC | 6,243,812 | $84.9M | 4.17% | +300,000+5.0% | Added |
| Vanguard Group Inc | 5,273,750 | $71.7M | 0.00% | +775,722+17.2% | Added |
| Saturn V Capital Management LLC | 4,604,878 | $62.6M | 13.72% | +1,344,308+41.2% | Added |
| Commodore Capital LP | 4,075,478 | $55.4M | 2.70% | +4,075,478 | New |
| First Light Asset Management, LLC | 3,355,882 | $45.6M | 4.30% | +3,355,882 | New |
| Point72 Asset Management, L.P. | 2,790,066 | $37.9M | 0.08% | −1,746,200−38.5% | Reduced |
| Janus Henderson Group PLC | 2,536,233 | $34.5M | 0.02% | +2,536,233 | New |
| Driehaus Capital Management LLC | 2,420,767 | $32.9M | 0.24% | +1,155,770+91.4% | Added |
| Almitas Capital LLC | 2,122,597 | $28.8M | 6.60% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 2,010,633 | $27.3M | 0.00% | +712,651+54.9% | Added |
| Morgan Stanley | 1,950,301 | $26.5M | 0.00% | +1,463,408+300.6% | Added |
| Paradigm Biocapital Advisors LP | 1,900,000 | $25.8M | 0.76% | +1,900,000 | New |
| Geode Capital Management, LLC | 1,812,039 | $24.6M | 0.00% | +119,626+7.1% | Added |
| 683 Capital Management, LLC | 1,760,000 | $23.9M | 2.17% | −400,000−18.5% | Reduced |
| Great Point Partners LLC | 1,700,000 | $23.1M | 9.65% | −300,000−15.0% | Reduced |
| State Street Corp | 1,621,260 | $22.0M | 0.00% | +612,351+60.7% | Added |
| Eventide Asset Management, LLC | 1,512,500 | $20.6M | 0.34% | +1,512,500 | New |
| Balyasny Asset Management LLC | 1,476,302 | $20.1M | 0.04% | +1,476,302 | New |
| Logos Global Management LP | 1,450,000 | $19.7M | 1.95% | +1,450,000 | New |
| UBS Group AG | 1,404,471 | $19.1M | 0.00% | +151,127+12.1% | Added |
| Deutsche Bank AG | 1,365,521 | $18.6M | 0.01% | +748,602+121.3% | Added |
| T. Rowe Price Investment Management, Inc. | 1,198,064 | $16.3M | 0.01% | +1,198,064 | New |
| Connor, Clark & Lunn Investment Management Ltd. | 1,107,008 | $15.0M | 0.05% | −47,477−4.1% | Reduced |
| Nantahala Capital Management, LLC | 935,684 | $12.7M | 0.79% | −1,998,721−68.1% | Reduced |
| Boxer Capital Management, LLC | 900,000 | $12.2M | 3.90% | −325,000−26.5% | Reduced |
| ADAR1 Capital Management, LLC | 866,202 | $11.8M | 1.17% | −338,899−28.1% | Reduced |
| Woodline Partners LP | 845,290 | $11.5M | 0.05% | −355,000−29.6% | Reduced |
| Northern Trust Corp | 822,237 | $11.2M | 0.00% | +2,073+0.3% | Added |
| Invesco Ltd. | 810,640 | $11.0M | 0.00% | +223,757+38.1% | Added |
| OrbiMed Advisors LLC | 750,600 | $10.2M | 0.24% | +437,400+139.7% | Added |
| Silverarc Capital Management, LLC | 700,000 | $9.51M | 1.38% | +700,000 | New |
| Charles Schwab Investment Management Inc | 645,185 | $8.77M | 0.00% | +56,774+9.6% | Added |
| Braidwell LP | 612,841 | $8.33M | 0.25% | +612,841 | New |
| Parkman Healthcare Partners LLC | 579,174 | $7.87M | 0.86% | −70,826−10.9% | Reduced |
| Jennison Associates LLC | 578,659 | $7.86M | 0.00% | +578,659 | New |
| Dimensional Fund Advisors LP | 509,780 | $6.94M | 0.00% | +136,041+36.4% | Added |
| Cormorant Asset Management, LP | 500,000 | $6.79M | 0.47% | +500,000 | New |
| Rock Springs Capital Management LP | 499,764 | $6.79M | 0.40% | 00.0% | Unchanged |
| Ally Bridge Group (NY) LLC | 437,391 | $5.94M | 4.98% | +437,391 | New |
| PFM Health Sciences, LP | 436,156 | $5.93M | 0.51% | −296,100−40.4% | Reduced |
| Bank of America Corp | 429,516 | $5.84M | 0.00% | −22,292−4.9% | Reduced |
| Millennium Management LLC | 417,771 | $5.68M | 0.00% | −1,094,287−72.4% | Reduced |
| Barclays PLC | 414,112 | $5.63M | 0.00% | +283,838+217.9% | Added |
| Acadian Asset Management LLC | 367,331 | $4.99M | 0.01% | −201,752−35.5% | Reduced |
| Acuta Capital Partners, LLC | 333,258 | $4.53M | 4.68% | +333,258 | New |
| Falcon Edge Capital, LP | 327,312 | $4.45M | 0.45% | +51,470+18.7% | Added |
| Patient Square Capital LP | 316,312 | $4.30M | 1.15% | +316,312 | New |
| StemPoint Capital LP | 276,884 | $3.76M | 0.76% | +276,884 | New |
| Polygon Management Ltd. | 258,242 | $3.51M | 0.51% | +39,492+18.1% | Added |
| Wellington Management Group LLP | 236,197 | $3.21M | 0.00% | −52,421−18.2% | Reduced |
| Citadel Advisors LLC | 234,673 | $3.19M | 0.00% | −1,008,254−81.1% | Reduced |
| Trexquant Investment LP | 222,876 | $3.03M | 0.03% | +222,876 | New |
| Federated Hermes, Inc. | 212,379 | $2.89M | 0.01% | +8,449+4.1% | Added |
| Aldebaran Capital, LLC | 204,474 | $2.78M | 2.55% | −13,353−6.1% | Reduced |
| Longaeva Partners L.P. | 200,000 | $2.72M | 0.58% | +200,000 | New |
| Bank of New York Mellon Corp | 182,956 | $2.49M | 0.00% | +32,119+21.3% | Added |
| SummitTX Capital, L.P. | 168,000 | $2.28M | 0.09% | +168,000 | New |
| Qube Research & Technologies Ltd | 167,106 | $2.27M | 0.00% | −270,920−61.9% | Reduced |
| Fred Alger Management, LLC | 164,042 | $2.23M | 0.01% | +164,042 | New |
| Nuveen, LLC | 160,419 | $2.18M | 0.00% | +4,883+3.1% | Added |
| Bank of Montreal | 143,752 | $1.95M | 0.00% | +240+0.2% | Added |
| Two Sigma Advisers, LP | 143,000 | $1.94M | 0.00% | −327,000−69.6% | Reduced |
| Ameriprise Financial Inc | 133,508 | $1.81M | 0.00% | +38,289+40.2% | Added |
| Kennondale Capital Management LLC | 108,615 | $1.48M | 1.13% | +13,450+14.1% | Added |
| Price T Rowe Associates Inc | 100,445 | $1.37M | 0.00% | +9,053+9.9% | Added |
| Tang Capital Management LLC | 100,000 | $1.36M | 0.05% | 00.0% | Unchanged |
| Diadema Partners LP | 100,000 | $1.36M | 0.95% | +100,000 | New |
| Rhumbline Advisers | 98,657 | $1.34M | 0.00% | −1,919−1.9% | Reduced |
| Two Sigma Investments, LP | 98,416 | $1.34M | 0.00% | −460,430−82.4% | Reduced |
| Wells Fargo & Company | 93,691 | $1.27M | 0.00% | +55,590+145.9% | Added |
| Royal Bank of Canada | 93,012 | $1.26M | 0.00% | +80,879+666.6% | Added |
| Dark Forest Capital Management LP | 86,795 | $1.18M | 0.04% | +86,795 | New |
| EAM Investors, LLC | 75,111 | $1.02M | 0.12% | −24,849−24.9% | Reduced |
| AQR Capital Management LLC | 73,640 | $1.00M | 0.00% | +73,640 | New |
| Alliancebernstein L.P. | 71,500 | $971.7K | 0.00% | +40,900+133.7% | Added |
| Maven Securities LTD | 70,000 | $951.3K | 0.18% | +70,000 | New |
| D. E. Shaw & Co., Inc. | 68,877 | $936.0K | 0.00% | −82,625−54.5% | Reduced |
| Legal & General Group Plc | 67,212 | $913.4K | 0.00% | +59,810+808.0% | Added |
| Numerai GP LLC | 67,153 | $912.6K | 0.13% | +67,153 | New |
| Verition Fund Management LLC | 63,896 | $868.3K | 0.00% | +63,896 | New |
| Readystate Asset Management LP | 59,132 | $803.6K | 0.04% | +59,132 | New |
| Brevan Howard Capital Management LP | 56,667 | $770.1K | 0.01% | +56,667 | New |
| Russell Investments Group, Ltd. | 55,406 | $753.0K | 0.00% | +49,177+789.5% | Added |
| Gsa Capital Partners LLP | 52,107 | $708.0K | 0.06% | −118,426−69.4% | Reduced |
| Mariner, LLC | 48,027 | $652.7K | 0.00% | −641−1.3% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 47,898 | $650.9K | 0.02% | −8,933−15.7% | Reduced |
| Schonfeld Strategic Advisors LLC | 43,637 | $593.0K | 0.00% | −602,806−93.2% | Reduced |
| MetLife Investment Management | 42,929 | $583.4K | 0.00% | 00.0% | Unchanged |
| TD Asset Management Inc | 40,966 | $556.7K | 0.00% | +40,966 | New |
| Citigroup Inc | 38,083 | $517.5K | 0.00% | +6,985+22.5% | Added |
| JPMorgan Chase & Co | 35,844 | $487.1K | 0.00% | −52,145−59.3% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 31,999 | $434.9K | 0.00% | −5,988−15.8% | Reduced |
| Monashee Investment Management LLC | 30,000 | $407.6K | 0.20% | +30,000 | New |
| Quadrature Capital Ltd | 28,286 | $384.1K | 0.00% | −1,144−3.9% | Reduced |
| Guggenheim Capital LLC | 24,899 | $338.4K | 0.00% | −10,853−30.4% | Reduced |
| Campbell & CO Investment Adviser LLC | 24,482 | $332.7K | 0.03% | +24,482 | New |