Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 169
- +38 vs. Q2 2025
- Shares held
- 109.7M
- +28.0M (+34.3%) vs. Q2 2025
- Total value
- $1.49B
- +$967.5M (+184.8%) vs. Q2 2025
- New holders
- 57
- 44 more added
- Sold out
- 19
- 48 more reduced
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Manufacturers Life Insurance Company, The | 23,790 | $323.3K | 0.00% | −2,209−8.5% | Reduced |
| Persistent Asset Partners Ltd | 22,913 | $311.4K | 0.23% | +22,913 | New |
| New York State Common Retirement Fund | 21,900 | $297.6K | 0.00% | 00.0% | Unchanged |
| Parsons Capital Management Inc | 21,645 | $294.2K | 0.02% | 00.0% | Unchanged |
| JustInvest LLC | 21,101 | $286.8K | 0.00% | −22−0.1% | Reduced |
| HSBC Holdings PLC | 19,369 | $278.1K | 0.00% | +19,369 | New |
| Premier Path Wealth Partners, LLC | 20,265 | $275.4K | 0.04% | 00.0% | Unchanged |
| Brown Advisory Inc | 19,930 | $270.8K | 0.00% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 19,900 | $270.4K | 0.00% | −376,300−95.0% | Reduced |
| Intech Investment Management LLC | 19,494 | $264.9K | 0.00% | −16,821−46.3% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 19,262 | $261.8K | 0.00% | +3,270+20.4% | Added |
| Oxford Asset Management LLP | 19,120 | $259.8K | 0.09% | +19,120 | New |
| EntryPoint Capital, LLC | 17,166 | $233.3K | 0.09% | +17,166 | New |
| Quantbot Technologies LP | 16,653 | $226.3K | 0.01% | +16,653 | New |
| China Universal Asset Management Co., Ltd. | 15,630 | $212.4K | 0.02% | −2,274−12.7% | Reduced |
| ProShare Advisors LLC | 15,038 | $204.4K | 0.00% | −2,513−14.3% | Reduced |
| BNP Paribas Arbitrage, SA | 14,609 | $198.5K | 0.00% | +7,342+101.0% | Added |
| State of Wisconsin Investment Board | 13,875 | $188.6K | 0.00% | +13,875 | New |
| Quest Partners LLC | 13,636 | $185.3K | 0.01% | +13,636 | New |
| Profund Advisors LLC | 13,418 | $182.4K | 0.01% | +13,418 | New |
| Voya Investment Management LLC | 12,990 | $176.5K | 0.00% | −6,486−33.3% | Reduced |
| SG Americas Securities, LLC | 11,819 | $161.0K | 0.00% | +11,819 | New |
| Capstone Investment Advisors, LLC | 10,634 | $144.5K | 0.00% | +10,634 | New |
| Landscape Capital Management, L.L.C. | 10,401 | $141.3K | 0.01% | +10,401 | New |
| Prudential Financial Inc | 10,155 | $138.0K | 0.00% | −5,465−35.0% | Reduced |
| Valeo Financial Advisors, LLC | 10,000 | $135.9K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 6,590 | $89.6K | 0.00% | −877−11.7% | Reduced |
| Point72 (DIFC) Ltd | 5,967 | $81.1K | 0.01% | +5,967 | New |
| Ameritas Investment Partners, Inc. | 5,794 | $78.7K | 0.00% | −1,287−18.2% | Reduced |
| Cubist Systematic Strategies, LLC | 5,603 | $76.1K | 0.00% | −117,639−95.5% | Reduced |
| California State Teachers Retirement System | 4,331 | $58.9K | 0.00% | +3+0.1% | Added |
| US Bancorp | 4,000 | $54.4K | 0.00% | 00.0% | Unchanged |
| Aster Capital Management (DIFC) Ltd | 3,568 | $48.5K | 0.02% | +3,568 | New |
| Mirae Asset Global Investments Co., Ltd. | 3,447 | $46.8K | 0.00% | +4+0.1% | Added |
| STRS Ohio | 3,400 | $46.2K | 0.00% | −3,900−53.4% | Reduced |
| Amalgamated Bank | 2,369 | $32.0K | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 2,244 | $30.5K | 0.00% | +2,244 | New |
| GF Fund Management Co. Ltd. | 1,918 | $26.1K | 0.00% | +218+12.8% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,906 | $25.9K | 0.00% | −917−32.5% | Reduced |
| Loring Wolcott & Coolidge Fiduciary Advisors LLP | 1,803 | $25.8K | 0.00% | 00.0% | Unchanged |
| Steward Partners Investment Advisory, LLC | 1,500 | $20.4K | 0.00% | −500−25.0% | Reduced |
| SBI Securities Co., Ltd. | 1,251 | $17.0K | 0.00% | +1,250+125,000.0% | Added |
| Sterling Capital Management LLC | 1,209 | $16.4K | 0.00% | +657+119.0% | Added |
| Clear Street Markets LLC | 1,191 | $16.2K | 0.01% | +1,191 | New |
| CWM, LLC | 1,186 | $16.0K | 0.00% | +296+33.3% | Added |
| Global Retirement Partners, LLC | 1,000 | $13.6K | 0.00% | −1,500−60.0% | Reduced |
| Dunhill Financial, LLC | 600 | $8.15K | 0.00% | 00.0% | Unchanged |
| North Capital, Inc. | 501 | $6.81K | 0.01% | +1+0.2% | Added |
| The PNC Financial Services Group, Inc. | 485 | $6.59K | 0.00% | +432+815.1% | Added |
| Caitong International Asset Management Co., Ltd | 366 | $4.97K | 0.00% | −2,547−87.4% | Reduced |
| Daiwa Securities Group Inc. | 266 | $4.00K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 285 | $3.87K | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 274 | $3.72K | 0.00% | 00.0% | Unchanged |
| Massmutual Trust Co FSB | 240 | $3.26K | 0.00% | +240 | New |
| Advisor Group Holdings, Inc. | 225 | $3.06K | 0.00% | −15−6.3% | Reduced |
| Evolution Wealth Management Inc. | 165 | $2.24K | 0.00% | +165 | New |
| GAMMA Investing LLC | 125 | $1.70K | 0.00% | +125 | New |
| Harbour Investments, Inc. | 90 | $1.22K | 0.00% | 00.0% | Unchanged |
| Catherine Avery Investment Management LLC | 87 | $1.18K | 0.00% | 00.0% | Unchanged |
| Rise Advisors, LLC | 64 | $870 | 0.00% | +64 | New |
| Salem Investment Counselors Inc | 55 | $748 | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 30 | $436 | 0.00% | +30 | New |
| EverSource Wealth Advisors, LLC | 25 | $340 | 0.00% | 00.0% | Unchanged |
| Financial Consulate, Inc | 25 | $340 | 0.00% | +25 | New |
| Farther Finance Advisors, LLC | 20 | $272 | 0.00% | +20 | New |
| Essential Partners LLC | 16 | $217 | 0.00% | +16 | New |
| Allworth Financial LP | 12 | $164 | 0.00% | +12 | New |
| Rockefeller Capital Management L.P. | 5 | $68 | 0.00% | +5 | New |
| IFP Advisors, Inc | 1 | $14 | 0.00% | +1 | New |
| Standard Life Aberdeen plc | 0 | $0 | 0.00% | −738,657−100.0% | Sold out |
| J. Goldman & Co LP | 0 | $0 | 0.00% | −258,600−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −240,379−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −186,986−100.0% | Sold out |
| American Century Companies Inc | 0 | $0 | 0.00% | −134,380−100.0% | Sold out |
| Allostery Investments LP | 0 | $0 | 0.00% | −120,119−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −110,846−100.0% | Sold out |
| Cantor Fitzgerald, L. P. | 0 | $0 | 0.00% | −50,000−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −47,800−100.0% | Sold out |
| Centiva Capital, LP | 0 | $0 | 0.00% | −45,464−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −40,643−100.0% | Sold out |
| Graham Capital Management, L.P. | 0 | $0 | 0.00% | −34,153−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −25,856−100.0% | Sold out |
| Bridgeway Capital Management, LLC | 0 | $0 | 0.00% | −25,700−100.0% | Sold out |
| Los Angeles Capital Management LLC | 0 | $0 | 0.00% | −23,320−100.0% | Sold out |
| Marex Group plc | 0 | $0 | 0.00% | −20,000−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −12,073−100.0% | Sold out |
| Raymond James Financial Inc | 0 | $0 | 0.00% | −104−100.0% | Sold out |
| Skopos Labs, Inc. | 0 | $0 | 0.00% | −42−100.0% | Sold out |