Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q1 2025
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 136
- +16 vs. Q4 2024
- Shares held
- 73.9M
- +24.1M (+48.4%) vs. Q4 2024
- Total value
- $261.6M
- +$73.3M (+39.0%) vs. Q4 2024
- New holders
- 32
- 50 more added
- Sold out
- 16
- 31 more reduced
2 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Perceptive Advisors LLC | 7,874,348 | $27.9M | 0.99% | +1,100,000+16.2% | Added |
| TCG Crossover Management, LLC | 5,943,812 | $21.0M | 2.87% | +1,300,000+28.0% | Added |
| Adage Capital Partners GP, L.L.C. | 5,697,605 | $20.2M | 0.04% | +5,697,605 | New |
| Vanguard Group Inc | 4,116,512 | $14.6M | 0.00% | +1,424,023+52.9% | Added |
| Millennium Management LLC | 3,081,853 | $10.9M | 0.01% | +2,487,617+418.6% | Added |
| Nantahala Capital Management, LLC | 2,934,405 | $10.4M | 0.86% | +1,482,252+102.1% | Added |
| Citadel Advisors LLC | 2,757,776 | $9.76M | 0.01% | +787,072+39.9% | Added |
| Standard Life Aberdeen plc | 2,430,358 | $8.60M | 0.02% | +707,553+41.1% | Added |
| Saturn V Capital Management LLC | 2,426,436 | $8.59M | 4.33% | +1,537,363+172.9% | Added |
| 683 Capital Management, LLC | 2,411,400 | $8.54M | 0.87% | +481,400+24.9% | Added |
| BlackRock, Inc. | 2,387,409 | $8.45M | 0.00% | +108,475+4.8% | Added |
| Almitas Capital LLC | 2,122,597 | $7.51M | 2.49% | +90,227+4.4% | Added |
| Goldman Sachs Group Inc | 2,002,961 | $7.09M | 0.00% | +143,065+7.7% | Added |
| Great Point Partners LLC | 1,811,996 | $6.41M | 3.49% | +1,811,996 | New |
| Boxer Capital Management, LLC | 1,750,000 | $6.20M | 1.86% | 00.0% | Unchanged |
| Woodline Partners LP | 1,609,447 | $5.70M | 0.04% | +1,609,447 | New |
| ADAR1 Capital Management, LLC | 1,471,587 | $5.21M | 1.00% | +1,471,587 | New |
| Susquehanna International Group, LLP | 1,470,925 | $5.21M | 0.01% | +602,543+69.4% | Added |
| UBS Group AG | 1,388,427 | $4.92M | 0.00% | +744,903+115.8% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 1,199,691 | $4.25M | 0.02% | −63,662−5.0% | Reduced |
| FMR LLC | 1,157,988 | $4.10M | 0.00% | +426,632+58.3% | Added |
| Qube Research & Technologies Ltd | 942,891 | $3.34M | 0.01% | +162,325+20.8% | Added |
| Point72 Asset Management, L.P. | 916,966 | $3.25M | 0.01% | +916,966 | New |
| PFM Health Sciences, LP | 834,135 | $2.95M | 0.23% | +834,135 | New |
| Geode Capital Management, LLC | 806,161 | $2.85M | 0.00% | +238,258+42.0% | Added |
| Bank of America Corp | 794,354 | $2.81M | 0.00% | −1,631,909−67.3% | Reduced |
| Two Sigma Investments, LP | 762,053 | $2.70M | 0.01% | +110,536+17.0% | Added |
| Alyeska Investment Group, L.P. | 750,412 | $2.66M | 0.01% | −73,008−8.9% | Reduced |
| Two Sigma Advisers, LP | 649,800 | $2.30M | 0.01% | +408,400+169.2% | Added |
| Deutsche Bank AG | 570,857 | $2.02M | 0.00% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 515,100 | $1.82M | 0.00% | +50,700+10.9% | Added |
| Morgan Stanley | 474,418 | $1.68M | 0.00% | +10,198+2.2% | Added |
| Citigroup Inc | 463,240 | $1.64M | 0.00% | −146,084−24.0% | Reduced |
| Charles Schwab Investment Management Inc | 372,853 | $1.32M | 0.00% | +73,904+24.7% | Added |
| OrbiMed Advisors LLC | 348,000 | $1.23M | 0.03% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 343,228 | $1.22M | 0.07% | +343,228 | New |
| Jane Street Group, LLC | 331,185 | $1.17M | 0.00% | −434,290−56.7% | Reduced |
| Wellington Management Group LLP | 290,682 | $1.03M | 0.00% | +80,974+38.6% | Added |
| D. E. Shaw & Co., Inc. | 270,006 | $955.8K | 0.00% | −36,738−12.0% | Reduced |
| Allostery Investments LP | 266,099 | $942.0K | 1.36% | +266,099 | New |
| State Street Corp | 261,783 | $926.7K | 0.00% | +43,400+19.9% | Added |
| Aldebaran Capital, LLC | 259,253 | $917.8K | 0.87% | −3,500−1.3% | Reduced |
| Walleye Capital LLC | 250,888 | $888.1K | 0.01% | −267,896−51.6% | Reduced |
| Marshall Wace, LLP | 247,275 | $875.4K | 0.00% | +62,597+33.9% | Added |
| Acadian Asset Management LLC | 242,107 | $855.0K | 0.00% | −369,819−60.4% | Reduced |
| Federated Hermes, Inc. | 202,785 | $717.9K | 0.00% | +469+0.2% | Added |
| Kennondale Capital Management LLC | 202,743 | $717.7K | 0.78% | +68,298+50.8% | Added |
| Falcon Edge Capital, LP | 187,311 | $663.1K | 0.30% | +38,684+26.0% | Added |
| Omers Administration Corp | 169,600 | $600.4K | 0.01% | +103,600+157.0% | Added |
| Bridgeway Capital Management, LLC | 155,700 | $551.2K | 0.01% | +9,200+6.3% | Added |
| Balyasny Asset Management LLC | 148,559 | $525.9K | 0.00% | +98,311+195.7% | Added |
| Bank of Montreal | 143,512 | $508.0K | 0.00% | 00.0% | Unchanged |
| Northern Trust Corp | 139,332 | $493.2K | 0.00% | +32,768+30.7% | Added |
| Barclays PLC | 137,405 | $486.4K | 0.00% | +62,560+83.6% | Added |
| HRT Financial LP | 127,998 | $453.0K | 0.00% | +127,998 | New |
| Dimensional Fund Advisors LP | 123,576 | $438.3K | 0.00% | +69,462+128.4% | Added |
| Schonfeld Strategic Advisors LLC | 117,140 | $414.7K | 0.00% | −76,791−39.6% | Reduced |
| American Century Companies Inc | 107,014 | $378.8K | 0.00% | +47,704+80.4% | Added |
| Tang Capital Management LLC | 100,000 | $354.0K | 0.02% | 00.0% | Unchanged |
| Cantor Fitzgerald, L. P. | 100,000 | $354.0K | 0.01% | +100,000 | New |
| Man Group plc | 87,352 | $309.2K | 0.00% | −12,707−12.7% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 83,236 | $294.7K | 0.01% | −7,383−8.1% | Reduced |
| Cubist Systematic Strategies, LLC | 83,130 | $294.3K | 0.00% | −389,267−82.4% | Reduced |
| Jacobs Levy Equity Management, Inc | 77,091 | $272.9K | 0.00% | −237,848−75.5% | Reduced |
| Squarepoint Ops LLC | 75,849 | $268.5K | 0.00% | +565+0.8% | Added |
| Jain Global LLC | 73,942 | $261.8K | 0.01% | +73,942 | New |
| Alps Advisors Inc | 67,597 | $239.3K | 0.00% | +12,167+22.0% | Added |
| ExodusPoint Capital Management, LP | 59,491 | $211.0K | 0.00% | −46,746−44.0% | Reduced |
| Price T Rowe Associates Inc | 57,700 | $205.0K | 0.00% | 00.0% | Unchanged |
| Algert Global LLC | 57,133 | $202.3K | 0.01% | +57,133 | New |
| JPMorgan Chase & Co | 54,069 | $191.4K | 0.00% | −1,537−2.8% | Reduced |
| Mariner, LLC | 50,906 | $180.2K | 0.00% | +367+0.7% | Added |
| Jefferies Financial Group Inc. | 46,200 | $163.5K | 0.00% | 00.0% | Unchanged |
| Invesco Ltd. | 45,694 | $161.8K | 0.00% | +45,694 | New |
| Group One Trading, L.P. | 43,234 | $153.0K | 0.01% | −6,665−13.4% | Reduced |
| LMR Partners LLP | 43,228 | $153.0K | 0.00% | +43,228 | New |
| Point72 Asia (Singapore) Pte. Ltd. | 43,200 | $152.9K | 0.04% | −29,663−40.7% | Reduced |
| Quantessence Capital LLC | 40,134 | $142.1K | 0.04% | +40,134 | New |
| XTX Topco Ltd | 39,542 | $140.0K | 0.01% | −13,834−25.9% | Reduced |
| Guggenheim Capital LLC | 37,796 | $133.8K | 0.00% | +1,928+5.4% | Added |
| Tudor Investment Corp Et Al | 33,428 | $118.3K | 0.00% | −259−0.8% | Reduced |
| Centiva Capital, LP | 28,222 | $99.9K | 0.01% | −5,609−16.6% | Reduced |
| Cannon Global Investment Management, LLC | 25,500 | $90.3K | 0.25% | +25,500 | New |
| SG Americas Securities, LLC | 25,210 | $89.0K | 0.00% | +9,252+58.0% | Added |
| Verition Fund Management LLC | 24,013 | $85.0K | 0.00% | +24,013 | New |
| Gsa Capital Partners LLP | 23,085 | $82.0K | 0.01% | +12,446+117.0% | Added |
| Paloma Partners Management Co | 22,242 | $78.7K | 0.01% | +22,242 | New |
| JustInvest LLC | 21,756 | $77.0K | 0.00% | +4,032+22.7% | Added |
| Parsons Capital Management Inc | 21,645 | $76.6K | 0.00% | 00.0% | Unchanged |
| Premier Path Wealth Partners, LLC | 20,265 | $71.7K | 0.01% | +20,265 | New |
| Marex Group plc | 20,000 | $70.8K | 0.00% | 00.0% | Unchanged |
| Brown Advisory Inc | 19,930 | $70.6K | 0.00% | 00.0% | Unchanged |
| China Universal Asset Management Co., Ltd. | 17,188 | $60.8K | 0.01% | +2,653+18.3% | Added |
| Capstone Investment Advisors, LLC | 16,150 | $57.2K | 0.00% | +16,150 | New |
| State of Wyoming | 15,920 | $56.4K | 0.01% | −157−1.0% | Reduced |
| Prudential Financial Inc | 15,200 | $53.8K | 0.00% | −4,200−21.6% | Reduced |
| Catalyst Funds Management Pty Ltd | 14,905 | $52.8K | 0.01% | +14,905 | New |
| HSBC Holdings PLC | 14,419 | $51.4K | 0.00% | +2,853+24.7% | Added |
| Engineers Gate Manager LP | 13,382 | $47.4K | 0.00% | −4,255−24.1% | Reduced |
| Two Sigma Securities, LLC | 13,301 | $47.1K | 0.01% | +13,301 | New |