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Amylyx Pharmaceuticals, Inc.

AMLX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001658551

In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.

13F holders, Q2 2022

Institutional positions in Amylyx Pharmaceuticals, Inc. as of Jun 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
78
+7 vs. Q1 2022
Shares held
26.6M
+3.20M (+13.7%) vs. Q1 2022
Total value
$512.9M
+$213.0M (+71.0%) vs. Q1 2022
New holders
20
35 more added
Sold out
13
13 more reduced

1 institution that held it in Q1 2022 haven't filed for Q2 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2022: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2022: 78 institutions
Q1 2021: 0 institutionsQ2 2021: 0 institutionsQ3 2021: 0 institutionsQ4 2021: 0 institutionsQ1 2022: 72 institutionsQ2 2022: 78 institutionsQ3 2022: 95 institutionsQ4 2022: 133 institutionsQ1 2023: 147 institutionsQ2 2023: 154 institutionsQ3 2023: 170 institutionsQ4 2023: 178 institutionsQ1 2024: 143 institutionsQ2 2024: 119 institutionsQ3 2024: 110 institutionsQ4 2024: 122 institutionsQ1 2025: 136 institutionsQ2 2025: 131 institutionsQ3 2025: 169 institutionsQ4 2025: 180 institutionsQ1 2026: 171 institutionsQ2 2026: 206 institutions
Value heldQ2 2022: $512.9M
Q1 2021: $0Q2 2021: $0Q3 2021: $0Q4 2021: $0Q1 2022: $299.9MQ2 2022: $512.9MQ3 2022: $1.06BQ4 2022: $1.79BQ1 2023: $1.52BQ2 2023: $1.18BQ3 2023: $1.09BQ4 2023: $939.5MQ1 2024: $154.4MQ2 2024: $83.0MQ3 2024: $141.2MQ4 2024: $189.1MQ1 2025: $261.6MQ2 2025: $523.7MQ3 2025: $1.52BQ4 2025: $1.36BQ1 2026: $1.60BQ2 2026: $2.07B
Institutions holding AMLX and their total value by quarter
QuarterHoldersValue
Q2 2026206$2.07B
Q1 2026171$1.60B
Q4 2025180$1.36B
Q3 2025169$1.52B
Q2 2025131$523.7M
Q1 2025136$261.6M
Q4 2024122$189.1M
Q3 2024110$141.2M
Q2 2024119$83.0M
Q1 2024143$154.4M
Q4 2023178$939.5M
Q3 2023170$1.09B
Q2 2023154$1.18B
Q1 2023147$1.52B
Q4 2022133$1.79B
Q3 202295$1.06B
Q2 202278$512.9M
Q1 202272$299.9M
Q4 20210$0
Q3 20210$0
Q2 20210$0
Q1 20210$0

Institutions, Q2 2022

Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q1 2022.

Institutions holding AMLX in Q2 2022
InstitutionSharesValue% of portfolioChange in sharesAction
Viking Global Investors LPSuperinvestorViking Global Investors7,170,536$138.1M0.63%00.0%Unchanged
Perceptive Advisors LLC3,540,408$68.2M2.14%+2,066,301+140.2%Added
Boxer Capital, LLC2,200,000$42.4M2.68%00.0%Unchanged
Bain Capital Life Sciences Investors, LLC1,948,214$37.5M4.40%−807,836−29.3%Reduced
Vanguard Group Inc994,001$19.1M0.00%+1,813+0.2%Added
Rock Springs Capital Management LP974,107$18.8M0.55%−24,200−2.4%Reduced
Verition Fund Management LLC950,129$18.3M0.40%+24,776+2.7%Added
Tybourne Capital Management (HK) Ltd768,603$14.8M1.07%00.0%Unchanged
Citadel Advisors LLC754,410$14.5M0.02%+252,774+50.4%Added
BlackRock Inc.709,432$13.7M0.00%+137,091+24.0%Added
Falcon Edge Capital, LP700,635$13.5M1.39%+83,415+13.5%Added
683 Capital Management, LLC677,714$13.0M0.94%00.0%Unchanged
Marshall Wace, LLP658,373$12.7M0.03%+73,909+12.6%Added
Millennium Management LLC446,044$8.59M0.01%+308,803+225.0%Added
Allspring Global Investments Holdings, LLC415,298$8.00M0.01%+12,974+3.2%Added
Woodline Partners LP390,229$7.52M0.12%00.0%Unchanged
Point72 Asset Management, L.P.312,461$6.02M0.03%+312,461New
Ikarian Capital, LLC246,554$4.75M1.97%−150,100−37.8%Reduced
Geode Capital Management, LLC231,417$4.46M0.00%+41,267+21.7%Added
Adage Capital Partners GP, L.L.C.200,000$3.85M0.01%+162,800+437.6%Added
State Street Corp196,465$3.78M0.00%+97,253+98.0%Added
Sofinnova Investments, Inc.187,381$3.61M0.32%+87,381+87.4%Added
Belvedere Trading LLC168,588$3.52M3.81%+168,588New
Jane Street Group, LLC179,602$3.46M0.01%+150,356+514.1%Added
Simplex Trading, LLC158,090$3.04M0.10%+152,892+2,941.4%Added
Group One Trading, L.P.155,388$2.99M0.09%+154,145+12,401.0%Added
Susquehanna International Group, LLP138,229$2.66M0.01%+91,664+196.9%Added
FMR LLC122,443$2.36M0.00%+34,318+38.9%Added
Ameriprise Financial Inc98,955$1.91M0.00%+16,645+20.2%Added
Northern Trust Corp94,541$1.82M0.00%+12,371+15.1%Added
SEI Investments Co93,854$1.81M0.00%+93,854New
Tri Locum Partners LP80,459$1.55M0.64%+80,459New
Artal Group S.A.75,000$1.45M0.08%00.0%Unchanged
Charles Schwab Investment Management Inc70,409$1.36M0.00%−2,618−3.6%Reduced
Caption Management, LLC69,651$1.34M0.12%+32,984+90.0%Added
Cubist Systematic Strategies, LLC53,000$1.02M0.01%+18,086+51.8%Added
Morgan Stanley43,106$829.0K0.00%+761+1.8%Added
Nuveen Asset Management, LLC39,487$761.0K0.00%+26,257+198.5%Added
Virtu Financial LLC36,003$693.0K0.06%+36,003New
Alliancebernstein L.P.35,900$691.0K0.00%+35,900New
Boothbay Fund Management, LLC34,500$664.0K0.02%−13,771−28.5%Reduced
Bank of New York Mellon Corp29,021$558.0K0.00%+2,570+9.7%Added
Picton Mahoney Asset Management23,200$446.0K0.02%+23,200New
Bank of America Corp16,570$319.0K0.00%+13,666+470.6%Added
Rhumbline Advisers16,174$312.0K0.00%+16,174New
ExodusPoint Capital Management, LP16,013$308.0K0.00%+16,013New
HAP Trading, LLC15,322$295.0K0.04%+15,322New
Pura Vida Investments, LLC10,550$203.0K0.03%+550+5.5%Added
New York State Common Retirement Fund9,197$177.0K0.00%+5,197+129.9%Added
Cutler Group LP7,711$148.0K0.02%+7,711New
MetLife Investment Management6,785$130.7K0.00%00.0%Unchanged
JPMorgan Chase & Co6,132$118.0K0.00%+1,635+36.4%Added
Walleye Trading LLC5,525$106.0K0.00%+5,525New
American International Group, Inc.5,368$103.0K0.00%+608+12.8%Added
Fred Alger Management, LLC5,129$99.0K0.00%+5,129New
California State Teachers Retirement System4,905$94.0K0.00%+819+20.0%Added
Deutsche Bank AG4,692$90.0K0.00%−657−12.3%Reduced
Tower Research Capital LLC (TRC)3,340$64.0K0.00%+2,629+369.8%Added
Advisor Group Holdings, Inc.1,950$37.0K0.00%+550+39.3%Added
PEAK6 Investments LLC1,500$32.4K0.00%+1,500New
Wells Fargo & Company1,578$30.0K0.00%−88,246−98.2%Reduced
Amalgamated Bank1,524$29.0K0.00%−239−13.6%Reduced
High Net Worth Advisory Group LLC1,500$29.0K0.01%+1,000+200.0%Added
Legal & General Group Plc1,224$24.0K0.00%+319+35.2%Added
STRS Ohio1,200$23.0K0.00%−1,100−47.8%Reduced
Steward Partners Investment Advisory, LLC1,100$21.0K0.00%00.0%Unchanged
Royal Bank of Canada1,008$19.0K0.00%−3,286−76.5%Reduced
Citigroup Inc835$16.0K0.00%−319−27.6%Reduced
Metropolitan Life Insurance Co795$15.3K0.00%00.0%Unchanged
Ameritas Investment Partners, Inc.744$14.0K0.00%00.0%Unchanged
Barclays PLC575$11.0K0.00%−984−63.1%Reduced
Credit Agricole S A500$10.0K0.00%+500New
Tradition Wealth Management, LLC500$10.0K0.00%+500New
UBS Group AG177$3.00K0.00%−3,980−95.7%Reduced
Glassman Wealth Services39$1.00K0.00%+39New
Credit Suisse AG11$00.00%+11New
Captrust Financial Advisors19$00.00%+19New
TCI Wealth Advisors, Inc.21$00.00%+21New
Agf Investments Inc.0$00.00%−160,000−100.0%Sold out
Renaissance Technologies LLC0$00.00%−146,400−100.0%Sold out
Balyasny Asset Management LLC0$00.00%−62,915−100.0%Sold out
Oasis Management Co Ltd.0$00.00%−50,000−100.0%Sold out
PFS Investments Inc.0$00.00%−39,558−100.0%Sold out
Atom Investors LP0$00.00%−36,691−100.0%Sold out
Silverarc Capital Management, LLC0$00.00%−30,000−100.0%Sold out
Walleye Capital LLC0$00.00%−28,187−100.0%Sold out
Caas Capital Management LP0$00.00%−17,000−100.0%Sold out
Squarepoint Ops LLC0$00.00%−15,000−100.0%Sold out
Quantbot Technologies LP0$00.00%−2,200−100.0%Sold out
Point72 Hong Kong Ltd0$00.00%−1,159−100.0%Sold out
Northwestern Mutual Wealth Management Co0$00.00%−300−100.0%Sold out
Amalgamated Financial Corp.––––Not filed