Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 169
- +38 vs. Q2 2025
- Shares held
- 109.7M
- +28.0M (+34.3%) vs. Q2 2025
- Total value
- $1.49B
- +$967.5M (+184.8%) vs. Q2 2025
- New holders
- 57
- 44 more added
- Sold out
- 19
- 48 more reduced
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| IFP Advisors, Inc | 1 | $14 | 0.00% | +1 | New |
| Rockefeller Capital Management L.P. | 5 | $68 | 0.00% | +5 | New |
| Allworth Financial LP | 12 | $164 | 0.00% | +12 | New |
| Essential Partners LLC | 16 | $217 | 0.00% | +16 | New |
| Farther Finance Advisors, LLC | 20 | $272 | 0.00% | +20 | New |
| EverSource Wealth Advisors, LLC | 25 | $340 | 0.00% | 00.0% | Unchanged |
| Financial Consulate, Inc | 25 | $340 | 0.00% | +25 | New |
| Jones Financial Companies LLLP | 30 | $436 | 0.00% | +30 | New |
| Salem Investment Counselors Inc | 55 | $748 | 0.00% | 00.0% | Unchanged |
| Rise Advisors, LLC | 64 | $870 | 0.00% | +64 | New |
| Catherine Avery Investment Management LLC | 87 | $1.18K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 90 | $1.22K | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 125 | $1.70K | 0.00% | +125 | New |
| Evolution Wealth Management Inc. | 165 | $2.24K | 0.00% | +165 | New |
| Advisor Group Holdings, Inc. | 225 | $3.06K | 0.00% | −15−6.3% | Reduced |
| Massmutual Trust Co FSB | 240 | $3.26K | 0.00% | +240 | New |
| UMA Financial Services, Inc. | 274 | $3.72K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 285 | $3.87K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 266 | $4.00K | 0.00% | 00.0% | Unchanged |
| Caitong International Asset Management Co., Ltd | 366 | $4.97K | 0.00% | −2,547−87.4% | Reduced |
| The PNC Financial Services Group, Inc. | 485 | $6.59K | 0.00% | +432+815.1% | Added |
| North Capital, Inc. | 501 | $6.81K | 0.01% | +1+0.2% | Added |
| Dunhill Financial, LLC | 600 | $8.15K | 0.00% | 00.0% | Unchanged |
| Global Retirement Partners, LLC | 1,000 | $13.6K | 0.00% | −1,500−60.0% | Reduced |
| CWM, LLC | 1,186 | $16.0K | 0.00% | +296+33.3% | Added |
| Clear Street Markets LLC | 1,191 | $16.2K | 0.01% | +1,191 | New |
| Sterling Capital Management LLC | 1,209 | $16.4K | 0.00% | +657+119.0% | Added |
| SBI Securities Co., Ltd. | 1,251 | $17.0K | 0.00% | +1,250+125,000.0% | Added |
| Steward Partners Investment Advisory, LLC | 1,500 | $20.4K | 0.00% | −500−25.0% | Reduced |
| Loring Wolcott & Coolidge Fiduciary Advisors LLP | 1,803 | $25.8K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,906 | $25.9K | 0.00% | −917−32.5% | Reduced |
| GF Fund Management Co. Ltd. | 1,918 | $26.1K | 0.00% | +218+12.8% | Added |
| SRS Capital Advisors, Inc. | 2,244 | $30.5K | 0.00% | +2,244 | New |
| Amalgamated Bank | 2,369 | $32.0K | 0.00% | 00.0% | Unchanged |
| STRS Ohio | 3,400 | $46.2K | 0.00% | −3,900−53.4% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 3,447 | $46.8K | 0.00% | +4+0.1% | Added |
| Aster Capital Management (DIFC) Ltd | 3,568 | $48.5K | 0.02% | +3,568 | New |
| US Bancorp | 4,000 | $54.4K | 0.00% | 00.0% | Unchanged |
| California State Teachers Retirement System | 4,331 | $58.9K | 0.00% | +3+0.1% | Added |
| Cubist Systematic Strategies, LLC | 5,603 | $76.1K | 0.00% | −117,639−95.5% | Reduced |
| Ameritas Investment Partners, Inc. | 5,794 | $78.7K | 0.00% | −1,287−18.2% | Reduced |
| Point72 (DIFC) Ltd | 5,967 | $81.1K | 0.01% | +5,967 | New |
| Tower Research Capital LLC (TRC) | 6,590 | $89.6K | 0.00% | −877−11.7% | Reduced |
| Valeo Financial Advisors, LLC | 10,000 | $135.9K | 0.00% | 00.0% | Unchanged |
| Prudential Financial Inc | 10,155 | $138.0K | 0.00% | −5,465−35.0% | Reduced |
| Landscape Capital Management, L.L.C. | 10,401 | $141.3K | 0.01% | +10,401 | New |
| Capstone Investment Advisors, LLC | 10,634 | $144.5K | 0.00% | +10,634 | New |
| SG Americas Securities, LLC | 11,819 | $161.0K | 0.00% | +11,819 | New |
| Voya Investment Management LLC | 12,990 | $176.5K | 0.00% | −6,486−33.3% | Reduced |
| Profund Advisors LLC | 13,418 | $182.4K | 0.01% | +13,418 | New |
| Quest Partners LLC | 13,636 | $185.3K | 0.01% | +13,636 | New |
| State of Wisconsin Investment Board | 13,875 | $188.6K | 0.00% | +13,875 | New |
| BNP Paribas Arbitrage, SA | 14,609 | $198.5K | 0.00% | +7,342+101.0% | Added |
| ProShare Advisors LLC | 15,038 | $204.4K | 0.00% | −2,513−14.3% | Reduced |
| China Universal Asset Management Co., Ltd. | 15,630 | $212.4K | 0.02% | −2,274−12.7% | Reduced |
| Quantbot Technologies LP | 16,653 | $226.3K | 0.01% | +16,653 | New |
| EntryPoint Capital, LLC | 17,166 | $233.3K | 0.09% | +17,166 | New |
| Oxford Asset Management LLP | 19,120 | $259.8K | 0.09% | +19,120 | New |
| Police & Firemen's Retirement System of New Jersey | 19,262 | $261.8K | 0.00% | +3,270+20.4% | Added |
| Intech Investment Management LLC | 19,494 | $264.9K | 0.00% | −16,821−46.3% | Reduced |
| Renaissance Technologies LLC | 19,900 | $270.4K | 0.00% | −376,300−95.0% | Reduced |
| Brown Advisory Inc | 19,930 | $270.8K | 0.00% | 00.0% | Unchanged |
| Premier Path Wealth Partners, LLC | 20,265 | $275.4K | 0.04% | 00.0% | Unchanged |
| HSBC Holdings PLC | 19,369 | $278.1K | 0.00% | +19,369 | New |
| JustInvest LLC | 21,101 | $286.8K | 0.00% | −22−0.1% | Reduced |
| Parsons Capital Management Inc | 21,645 | $294.2K | 0.02% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 21,900 | $297.6K | 0.00% | 00.0% | Unchanged |
| Persistent Asset Partners Ltd | 22,913 | $311.4K | 0.23% | +22,913 | New |
| Manufacturers Life Insurance Company, The | 23,790 | $323.3K | 0.00% | −2,209−8.5% | Reduced |
| Campbell & CO Investment Adviser LLC | 24,482 | $332.7K | 0.03% | +24,482 | New |
| Guggenheim Capital LLC | 24,899 | $338.4K | 0.00% | −10,853−30.4% | Reduced |
| Quadrature Capital Ltd | 28,286 | $384.1K | 0.00% | −1,144−3.9% | Reduced |
| Monashee Investment Management LLC | 30,000 | $407.6K | 0.20% | +30,000 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 31,999 | $434.9K | 0.00% | −5,988−15.8% | Reduced |
| JPMorgan Chase & Co | 35,844 | $487.1K | 0.00% | −52,145−59.3% | Reduced |
| Citigroup Inc | 38,083 | $517.5K | 0.00% | +6,985+22.5% | Added |
| TD Asset Management Inc | 40,966 | $556.7K | 0.00% | +40,966 | New |
| MetLife Investment Management | 42,929 | $583.4K | 0.00% | 00.0% | Unchanged |
| Schonfeld Strategic Advisors LLC | 43,637 | $593.0K | 0.00% | −602,806−93.2% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 47,898 | $650.9K | 0.02% | −8,933−15.7% | Reduced |
| Mariner, LLC | 48,027 | $652.7K | 0.00% | −641−1.3% | Reduced |
| Gsa Capital Partners LLP | 52,107 | $708.0K | 0.06% | −118,426−69.4% | Reduced |
| Russell Investments Group, Ltd. | 55,406 | $753.0K | 0.00% | +49,177+789.5% | Added |
| Brevan Howard Capital Management LP | 56,667 | $770.1K | 0.01% | +56,667 | New |
| Readystate Asset Management LP | 59,132 | $803.6K | 0.04% | +59,132 | New |
| Verition Fund Management LLC | 63,896 | $868.3K | 0.00% | +63,896 | New |
| Numerai GP LLC | 67,153 | $912.6K | 0.13% | +67,153 | New |
| Legal & General Group Plc | 67,212 | $913.4K | 0.00% | +59,810+808.0% | Added |
| D. E. Shaw & Co., Inc. | 68,877 | $936.0K | 0.00% | −82,625−54.5% | Reduced |
| Maven Securities LTD | 70,000 | $951.3K | 0.18% | +70,000 | New |
| Alliancebernstein L.P. | 71,500 | $971.7K | 0.00% | +40,900+133.7% | Added |
| AQR Capital Management LLC | 73,640 | $1.00M | 0.00% | +73,640 | New |
| EAM Investors, LLC | 75,111 | $1.02M | 0.12% | −24,849−24.9% | Reduced |
| Dark Forest Capital Management LP | 86,795 | $1.18M | 0.04% | +86,795 | New |
| Royal Bank of Canada | 93,012 | $1.26M | 0.00% | +80,879+666.6% | Added |
| Wells Fargo & Company | 93,691 | $1.27M | 0.00% | +55,590+145.9% | Added |
| Two Sigma Investments, LP | 98,416 | $1.34M | 0.00% | −460,430−82.4% | Reduced |
| Rhumbline Advisers | 98,657 | $1.34M | 0.00% | −1,919−1.9% | Reduced |
| Tang Capital Management LLC | 100,000 | $1.36M | 0.05% | 00.0% | Unchanged |
| Diadema Partners LP | 100,000 | $1.36M | 0.95% | +100,000 | New |