Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 180
- +13 vs. Q3 2025
- Shares held
- 112.3M
- +2.61M (+2.4%) vs. Q3 2025
- Total value
- $1.36B
- −$134.1M (−9.0%) vs. Q3 2025
- New holders
- 40
- 72 more added
- Sold out
- 27
- 44 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Verition Fund Management LLC | 29,487 | $356.2K | 0.00% | −34,409−53.9% | Reduced |
| AQR Capital Management LLC | 27,847 | $336.4K | 0.00% | −45,793−62.2% | Reduced |
| Integrated Quantitative Investments LLC | 27,234 | $329.0K | 0.07% | +27,234 | New |
| Manufacturers Life Insurance Company, The | 26,988 | $326.0K | 0.00% | +3,198+13.4% | Added |
| Guggenheim Capital LLC | 25,243 | $304.9K | 0.00% | +344+1.4% | Added |
| BNP Paribas Arbitrage, SA | 25,201 | $304.4K | 0.00% | +10,592+72.5% | Added |
| Aquatic Capital Management LLC | 24,352 | $294.2K | 0.01% | +24,352 | New |
| Police & Firemen's Retirement System of New Jersey | 23,752 | $286.9K | 0.00% | +4,490+23.3% | Added |
| Arizona State Retirement System | 22,914 | $276.8K | 0.00% | +22,914 | New |
| Tudor Investment Corp Et Al | 22,402 | $270.6K | 0.00% | +22,402 | New |
| New York State Common Retirement Fund | 21,900 | $264.6K | 0.00% | 00.0% | Unchanged |
| Parsons Capital Management Inc | 21,645 | $261.5K | 0.01% | 00.0% | Unchanged |
| ProShare Advisors LLC | 21,068 | $254.5K | 0.00% | +6,030+40.1% | Added |
| Schonfeld Strategic Advisors LLC | 21,052 | $254.3K | 0.00% | −22,585−51.8% | Reduced |
| SG Americas Securities, LLC | 20,846 | $252.0K | 0.00% | +9,027+76.4% | Added |
| JustInvest LLC | 20,840 | $251.7K | 0.00% | −261−1.2% | Reduced |
| Profund Advisors LLC | 20,589 | $248.7K | 0.01% | +7,171+53.4% | Added |
| Virtus Investment Advisers, Inc. | 20,307 | $245.3K | 0.07% | +20,307 | New |
| Premier Path Wealth Partners, LLC | 20,265 | $244.8K | 0.03% | 00.0% | Unchanged |
| Brown Advisory Inc | 19,930 | $240.8K | 0.00% | 00.0% | Unchanged |
| Engineers Gate Manager LP | 18,358 | $221.8K | 0.00% | +18,358 | New |
| China Universal Asset Management Co., Ltd. | 17,895 | $216.2K | 0.02% | +2,265+14.5% | Added |
| Rafferty Asset Management, LLC | 17,673 | $213.5K | 0.00% | +17,673 | New |
| KLP Kapitalforvaltning AS | 17,400 | $210.2K | 0.00% | +17,400 | New |
| Jupiter Asset Management Ltd | 15,574 | $188.1K | 0.00% | +15,574 | New |
| Royal Bank of Canada | 15,643 | $188.0K | 0.00% | −77,369−83.2% | Reduced |
| Quadrature Capital Ltd | 15,465 | $186.8K | 0.00% | −12,821−45.3% | Reduced |
| Voya Investment Management LLC | 15,247 | $184.2K | 0.00% | +2,257+17.4% | Added |
| Valeo Financial Advisors, LLC | 15,000 | $181.2K | 0.00% | +5,000+50.0% | Added |
| Landscape Capital Management, L.L.C. | 12,226 | $147.7K | 0.01% | +1,825+17.5% | Added |
| Teacher Retirement System of Texas | 12,174 | $147.1K | 0.00% | +12,174 | New |
| Seven Fleet Capital Management LP | 11,571 | $139.8K | 0.09% | +11,571 | New |
| Victory Capital Management Inc | 10,552 | $127.5K | 0.00% | +10,552 | New |
| EntryPoint Capital, LLC | 10,487 | $126.7K | 0.05% | −6,679−38.9% | Reduced |
| ACT Capital Management, LLC | 9,000 | $108.7K | 0.09% | +9,000 | New |
| Tower Research Capital LLC (TRC) | 8,095 | $97.8K | 0.00% | +1,505+22.8% | Added |
| Ameritas Investment Partners, Inc. | 7,203 | $87.0K | 0.00% | +1,409+24.3% | Added |
| Quest Partners LLC | 7,195 | $86.9K | 0.00% | −6,441−47.2% | Reduced |
| Walleye Capital LLC | 5,740 | $69.3K | 0.00% | +5,740 | New |
| Mirae Asset Global Investments Co., Ltd. | 5,337 | $64.5K | 0.00% | +1,890+54.8% | Added |
| T. Rowe Price Investment Management, Inc. | 4,517 | $55.0K | 0.00% | −1,193,547−99.6% | Reduced |
| Caitong International Asset Management Co., Ltd | 3,859 | $46.6K | 0.01% | +3,493+954.4% | Added |
| Simplex Trading, LLC | 3,727 | $45.0K | 0.00% | +3,727 | New |
| STRS Ohio | 3,400 | $41.1K | 0.00% | 00.0% | Unchanged |
| Walleye Trading LLC | 2,825 | $34.1K | 0.00% | +2,825 | New |
| Amalgamated Bank | 2,788 | $34.0K | 0.00% | +419+17.7% | Added |
| SRS Capital Advisors, Inc. | 2,550 | $30.8K | 0.00% | +306+13.6% | Added |
| Loring Wolcott & Coolidge Fiduciary Advisors LLP | 1,803 | $27.9K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 2,158 | $26.1K | 0.00% | +240+12.5% | Added |
| Meeder Asset Management Inc | 2,099 | $25.4K | 0.00% | +2,099 | New |
| US Bancorp | 2,000 | $24.2K | 0.00% | −2,000−50.0% | Reduced |
| Sterling Capital Management LLC | 1,627 | $19.7K | 0.00% | +418+34.6% | Added |
| Steward Partners Investment Advisory, LLC | 1,500 | $18.1K | 0.00% | 00.0% | Unchanged |
| State of Wyoming | 1,381 | $16.7K | 0.00% | +1,381 | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,315 | $16.0K | 0.00% | +1,315 | New |
| CWM, LLC | 1,193 | $14.0K | 0.00% | +7+0.6% | Added |
| Los Angeles Capital Management LLC | 852 | $12.0K | 0.00% | +852 | New |
| Nisa Investment Advisors, LLC | 922 | $11.1K | 0.00% | +637+223.5% | Added |
| Westfuller Advisors, LLC | 819 | $9.89K | 0.00% | +819 | New |
| Dunhill Financial, LLC | 600 | $7.25K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 438 | $5.29K | 0.00% | −47−9.7% | Reduced |
| UMA Financial Services, Inc. | 274 | $3.31K | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 267 | $3.23K | 0.00% | +142+113.6% | Added |
| Rockefeller Capital Management L.P. | 261 | $3.15K | 0.00% | +256+5,120.0% | Added |
| Advisor Group Holdings, Inc. | 249 | $3.01K | 0.00% | +24+10.7% | Added |
| Daiwa Securities Group Inc. | 266 | $3.00K | 0.00% | 00.0% | Unchanged |
| Evolution Wealth Management Inc. | 165 | $1.99K | 0.00% | 00.0% | Unchanged |
| Massmutual Trust Co FSB | 153 | $1.85K | 0.00% | −87−36.3% | Reduced |
| J.Safra Asset Management Corp | 123 | $1.49K | 0.00% | +123 | New |
| Harbour Investments, Inc. | 90 | $1.09K | 0.00% | 00.0% | Unchanged |
| Catherine Avery Investment Management LLC | 87 | $1.05K | 0.00% | 00.0% | Unchanged |
| Larson Financial Group LLC | 41 | $495 | 0.00% | +41 | New |
| Jones Financial Companies LLLP | 30 | $362 | 0.00% | 00.0% | Unchanged |
| Financial Consulate, Inc | 25 | $302 | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 25 | $302 | 0.00% | 00.0% | Unchanged |
| Farther Finance Advisors, LLC | 20 | $242 | 0.00% | 00.0% | Unchanged |
| Essential Partners LLC | 17 | $205 | 0.00% | +1+6.3% | Added |
| Allworth Financial LP | 12 | $145 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 1 | $12 | 0.00% | −1,250−99.9% | Reduced |
| IFP Advisors, Inc | 1 | $12 | 0.00% | 00.0% | Unchanged |
| Paradigm Biocapital Advisors LP | 0 | $0 | 0.00% | −1,900,000−100.0% | Sold out |
| OrbiMed Advisors LLC | 0 | $0 | 0.00% | −750,600−100.0% | Sold out |
| Braidwell LP | 0 | $0 | 0.00% | −612,841−100.0% | Sold out |
| Jennison Associates LLC | 0 | $0 | 0.00% | −578,659−100.0% | Sold out |
| Ally Bridge Group (NY) LLC | 0 | $0 | 0.00% | −437,391−100.0% | Sold out |
| Longaeva Partners L.P. | 0 | $0 | 0.00% | −200,000−100.0% | Sold out |
| Fred Alger Management, LLC | 0 | $0 | 0.00% | −164,042−100.0% | Sold out |
| Tang Capital Management LLC | 0 | $0 | 0.00% | −100,000−100.0% | Sold out |
| Diadema Partners LP | 0 | $0 | 0.00% | −100,000−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −86,795−100.0% | Sold out |
| Maven Securities LTD | 0 | $0 | 0.00% | −70,000−100.0% | Sold out |
| Readystate Asset Management LP | 0 | $0 | 0.00% | −59,132−100.0% | Sold out |
| Brevan Howard Capital Management LP | 0 | $0 | 0.00% | −56,667−100.0% | Sold out |
| Hennion & Walsh Asset Management, Inc. | 0 | $0 | 0.00% | −47,898−100.0% | Sold out |
| TD Asset Management Inc | 0 | $0 | 0.00% | −40,966−100.0% | Sold out |
| Monashee Investment Management LLC | 0 | $0 | 0.00% | −30,000−100.0% | Sold out |
| HSBC Holdings PLC | 0 | $0 | 0.00% | −19,369−100.0% | Sold out |
| Oxford Asset Management LLP | 0 | $0 | 0.00% | −19,120−100.0% | Sold out |
| Quantbot Technologies LP | 0 | $0 | 0.00% | −16,653−100.0% | Sold out |
| Capstone Investment Advisors, LLC | 0 | $0 | 0.00% | −10,634−100.0% | Sold out |