Amylyx Pharmaceuticals, Inc.

AMLX

Exchange: Nasdaq
Industry: Pharmaceutical Preparations
SEC CIK: 0001658551

SEC filings (opens in a new tab)

In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.

Q2 2026 vs. Q1 2026

How the institutions holding Amylyx Pharmaceuticals, Inc. changed between Q1 2026 and Q2 2026.

All holders in Q2 2026 All holders in Q1 2026

13F holders of AMLX: Q1 2026 compared with Q2 2026
Measure	Q1 2026	Of which not filed for Q2 2026	Q2 2026	Change
Holders	171	2	206	+37
Shares	114.1M	4.99M	115.0M	+5.82M (+5.3%)
Value	$1.59B	$69.3M	$2.07B	+$549.0M (+36.2%)

2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so the changes leave them out.

New holders (50)

Institutions that held Amylyx Pharmaceuticals, Inc. at the end of Q2 2026 but not at the end of Q1 2026.

Institutions new to AMLX in Q2 2026
Institution	Shares	Value	% of portfolio
Jupiter Topco LLC	5,236,102	$94.0M	0.04%
Alyeska Investment Group, L.P.	1,053,015	$18.9M	0.05%
Standard Life Aberdeen plc	737,670	$13.2M	0.02%
Nearwater Capital Markets, Ltd	425,000	$7.63M	0.13%
Trexquant Investment LP	349,439	$6.28M	0.04%
Ensign Peak Advisors, Inc	305,441	$5.49M	0.01%
Jane Street Group, LLC	299,565	$5.38M	0.00%
First Trust Advisors LP	254,587	$4.57M	0.00%
OrbiMed Advisors LLC	183,400	$3.29M	0.06%
Norges Bank	159,900	$2.87M	0.00%
Ameriprise Financial Inc	125,484	$2.25M	0.00%
Lighthouse Investment Partners, LLC	122,909	$2.21M	0.07%
Ikarian Capital, LLC	117,500	$2.11M	0.35%
Affinity Asset Advisors, LLC	98,999	$1.78M	0.09%
Quantinno Capital Management LP	80,850	$1.45M	0.00%
1492 Capital Management LLC	79,751	$1.43M	0.42%
CI Private Wealth, LLC	59,322	$1.07M	0.00%
Moody Aldrich Partners LLC	57,802	$1.04M	0.19%
SG Americas Securities, LLC	55,321	$994.0K	0.00%
Hudson Bay Capital Management LP	50,000	$898.0K	0.00%
Fox Run Management, L.L.C.	44,817	$804.9K	0.13%
Aquatic Capital Management LLC	39,425	$708.1K	0.02%
Gsa Capital Partners LLP	39,241	$705.0K	0.04%
Boothbay Fund Management, LLC	36,060	$647.6K	0.01%
Jennison Associates LLC	35,841	$643.7K	0.00%
Sound Capital Solutions LLC	31,890	$572.7K	0.13%
Jain Global LLC	28,770	$516.7K	0.01%
Canada Pension Plan Investment Board	27,600	$495.7K	0.00%
Jump Financial, LLC	26,891	$483.0K	0.00%
XTX Topco Ltd	25,864	$464.5K	0.01%
HRT Financial LP	23,870	$428.0K	0.00%
Martingale Asset Management L P	22,573	$405.4K	0.01%
Rafferty Asset Management, LLC	14,758	$265.1K	0.00%
Glenmede Trust Co NA	13,685	$245.8K	0.00%
Graham Capital Management, L.P.	12,364	$222.1K	0.01%
Magnetar Financial LLC	11,722	$210.5K	0.00%
Brevan Howard Capital Management LP	11,611	$208.5K	0.00%
Harvest Investment Services, LLC	10,214	$183.4K	0.03%
Fulcrum Asset Management LLP	4,400	$82.3K	0.01%
Group One Trading, L.P.	1,624	$29.2K	0.00%
Kemnay Advisory Services Inc.	928	$16.7K	0.00%
Strive Financial Group ,LLC	650	$11.7K	0.01%
Silver Grove Financial Group, Inc.	424	$7.62K	0.00%
Aster Capital Management (DIFC) Ltd	393	$7.06K	0.00%
Optiver Holding B.V.	220	$3.95K	0.00%
Picton Mahoney Asset Management	189	$3.39K	0.00%
Caption Management, LLC	174	$3.13K	0.00%
Quarry LP	139	$2.50K	0.00%
Catherine Avery Investment Management LLC	87	$1.56K	0.00%
Global Retirement Partners, LLC	14	$251	0.00%

Sold out (13)

Institutions that held Amylyx Pharmaceuticals, Inc. at the end of Q1 2026 and filed for Q2 2026 without it.

Institutions that sold out of AMLX in Q2 2026
Institution	Shares, Q1 2026	Value, Q1 2026
Squarepoint Ops LLC	114,877	$1.60M
Point72 Asset Management, L.P.	106,535	$1.48M
EAM Investors, LLC	53,256	$740.3K
Integrated Quantitative Investments LLC	27,234	$378.6K
Headlands Technologies LLC	19,814	$275.4K
Verition Fund Management LLC	13,264	$184.4K
Landscape Capital Management, L.L.C.	12,226	$169.9K
MAI Capital Management	9,014	$125.3K
ACT Capital Management, LLC	9,000	$125.1K
Meeder Asset Management Inc	661	$9.19K
Dunhill Financial, LLC	600	$8.34K
Stone House Investment Management, LLC	73	$1.01K
Ameritas Advisory Services, LLC	3	$42

Not filed for Q2 2026 yet (2)

Institutions that held Amylyx Pharmaceuticals, Inc. at the end of Q1 2026 and haven't filed a 13F for Q2 2026. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding AMLX in Q1 2026 that haven't filed for Q2 2026
Institution	Shares, Q1 2026	Value, Q1 2026
Janus Henderson Group PLC	4,986,073	$69.3M
CWM, LLC	1,263	$17.6K