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Amylyx Pharmaceuticals, Inc.

AMLX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001658551

In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.

13F holders, Q2 2025

Institutional positions in Amylyx Pharmaceuticals, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
131
−5 vs. Q1 2025
Shares held
81.7M
+7.79M (+10.5%) vs. Q1 2025
Total value
$523.6M
+$262.0M (+100.2%) vs. Q1 2025
New holders
31
37 more added
Sold out
36
37 more reduced

Compare with Q1 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2025: 131 institutions
Q1 2021: 0 institutionsQ2 2021: 0 institutionsQ3 2021: 0 institutionsQ4 2021: 0 institutionsQ1 2022: 72 institutionsQ2 2022: 78 institutionsQ3 2022: 95 institutionsQ4 2022: 133 institutionsQ1 2023: 147 institutionsQ2 2023: 154 institutionsQ3 2023: 170 institutionsQ4 2023: 178 institutionsQ1 2024: 143 institutionsQ2 2024: 119 institutionsQ3 2024: 110 institutionsQ4 2024: 122 institutionsQ1 2025: 136 institutionsQ2 2025: 131 institutionsQ3 2025: 169 institutionsQ4 2025: 180 institutionsQ1 2026: 171 institutionsQ2 2026: 206 institutions
Value heldQ2 2025: $523.6M
Q1 2021: $0Q2 2021: $0Q3 2021: $0Q4 2021: $0Q1 2022: $299.9MQ2 2022: $512.9MQ3 2022: $1.05BQ4 2022: $1.79BQ1 2023: $1.51BQ2 2023: $1.18BQ3 2023: $1.08BQ4 2023: $887.4MQ1 2024: $141.5MQ2 2024: $82.9MQ3 2024: $140.8MQ4 2024: $188.3MQ1 2025: $261.6MQ2 2025: $523.6MQ3 2025: $1.49BQ4 2025: $1.36BQ1 2026: $1.59BQ2 2026: $2.07B
Institutions holding AMLX and their total value by quarter
QuarterHoldersValue
Q2 2026206$2.07B
Q1 2026171$1.59B
Q4 2025180$1.36B
Q3 2025169$1.49B
Q2 2025131$523.6M
Q1 2025136$261.6M
Q4 2024122$188.3M
Q3 2024110$140.8M
Q2 2024119$82.9M
Q1 2024143$141.5M
Q4 2023178$887.4M
Q3 2023170$1.08B
Q2 2023154$1.18B
Q1 2023147$1.51B
Q4 2022133$1.79B
Q3 202295$1.05B
Q2 202278$512.9M
Q1 202272$299.9M
Q4 20210$0
Q3 20210$0
Q2 20210$0
Q1 20210$0

Institutions, Q2 2025

Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q1 2025.

Institutions holding AMLX in Q2 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Legal & General Group Plc7,402$47.4K0.00%+7,402New
STRS Ohio7,300$46.8K0.00%+7,300New
BNP Paribas Arbitrage, SA7,267$46.6K0.00%+5,904+433.2%Added
Ameritas Investment Partners, Inc.7,081$45.4K0.00%+7,081New
Russell Investments Group, Ltd.6,229$39.9K0.00%−471−7.0%Reduced
California State Teachers Retirement System4,328$27.7K0.00%+4,328New
US Bancorp4,000$25.6K0.00%00.0%Unchanged
Mirae Asset Global Investments Co., Ltd.3,443$22.1K0.00%+513+17.5%Added
Caitong International Asset Management Co., Ltd2,913$18.7K0.01%+684+30.7%Added
Zurcher Kantonalbank (Zurich Cantonalbank)2,823$18.1K0.00%−329−10.4%Reduced
Global Retirement Partners, LLC2,500$16.0K0.00%+2,500New
Amalgamated Bank2,369$15.0K0.00%+2,369New
Steward Partners Investment Advisory, LLC2,000$12.8K0.00%00.0%Unchanged
Loring Wolcott & Coolidge Fiduciary Advisors LLP1,803$11.6K0.00%00.0%Unchanged
GF Fund Management Co. Ltd.1,700$10.9K0.00%00.0%Unchanged
CWM, LLC890$6.00K0.00%00.0%Unchanged
Dunhill Financial, LLC600$3.85K0.00%00.0%Unchanged
Sterling Capital Management LLC552$3.54K0.00%+552New
North Capital, Inc.500$3.21K0.00%00.0%Unchanged
Daiwa Securities Group Inc.266$2.00K0.00%00.0%Unchanged
Nisa Investment Advisors, LLC285$1.83K0.00%00.0%Unchanged
UMA Financial Services, Inc.274$1.76K0.00%00.0%Unchanged
Advisor Group Holdings, Inc.240$1.54K0.00%+240New
Raymond James Financial Inc104$6670.00%+104New
Harbour Investments, Inc.90$5770.00%00.0%Unchanged
Catherine Avery Investment Management LLC87$5580.00%00.0%Unchanged
Salem Investment Counselors Inc55$3530.00%00.0%Unchanged
The PNC Financial Services Group, Inc.53$3400.00%00.0%Unchanged
Skopos Labs, Inc.42$2700.00%+42New
EverSource Wealth Advisors, LLC25$1600.00%00.0%Unchanged
SBI Securities Co., Ltd.1$60.00%00.0%Unchanged
Alyeska Investment Group, L.P.0$00.00%−750,412−100.0%Sold out
Walleye Capital LLC0$00.00%−250,888−100.0%Sold out
Marshall Wace, LLP0$00.00%−247,275−100.0%Sold out
Omers Administration Corp0$00.00%−169,600−100.0%Sold out
Balyasny Asset Management LLC0$00.00%−148,559−100.0%Sold out
HRT Financial LP0$00.00%−127,998−100.0%Sold out
Man Group plc0$00.00%−87,352−100.0%Sold out
Jacobs Levy Equity Management, Inc0$00.00%−77,091−100.0%Sold out
Jain Global LLC0$00.00%−73,942−100.0%Sold out
Alps Advisors Inc0$00.00%−67,597−100.0%Sold out
ExodusPoint Capital Management, LP0$00.00%−59,491−100.0%Sold out
Algert Global LLC0$00.00%−57,133−100.0%Sold out
Jefferies Financial Group Inc.0$00.00%−46,200−100.0%Sold out
LMR Partners LLP0$00.00%−43,228−100.0%Sold out
Point72 Asia (Singapore) Pte. Ltd.0$00.00%−43,200−100.0%Sold out
Quantessence Capital LLC0$00.00%−40,134−100.0%Sold out
XTX Topco Ltd0$00.00%−39,542−100.0%Sold out
Cannon Global Investment Management, LLC0$00.00%−25,500−100.0%Sold out
SG Americas Securities, LLC0$00.00%−25,210−100.0%Sold out
Verition Fund Management LLC0$00.00%−24,013−100.0%Sold out
Paloma Partners Management Co0$00.00%−22,242−100.0%Sold out
Capstone Investment Advisors, LLC0$00.00%−16,150−100.0%Sold out
State of Wyoming0$00.00%−15,920−100.0%Sold out
Catalyst Funds Management Pty Ltd0$00.00%−14,905−100.0%Sold out
HSBC Holdings PLC0$00.00%−14,419−100.0%Sold out
Engineers Gate Manager LP0$00.00%−13,382−100.0%Sold out
Two Sigma Securities, LLC0$00.00%−13,301−100.0%Sold out
R Squared Ltd0$00.00%−12,736−100.0%Sold out
Brevan Howard Capital Management LP0$00.00%−11,330−100.0%Sold out
Capula Management Ltd0$00.00%−10,980−100.0%Sold out
EntryPoint Capital, LLC0$00.00%−10,587−100.0%Sold out
Hudson Bay Capital Management LP0$00.00%−10,340−100.0%Sold out
Point72 (DIFC) Ltd0$00.00%−5,047−100.0%Sold out
Simplex Trading, LLC0$00.00%−4,162−100.0%Sold out
Advisors Asset Management, Inc.0$00.00%−2,573−100.0%Sold out
Coldstream Capital Management Inc0$00.00%−238−100.0%Sold out