Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 169
- +38 vs. Q2 2025
- Shares held
- 109.7M
- +28.0M (+34.3%) vs. Q2 2025
- Total value
- $1.49B
- +$967.5M (+184.8%) vs. Q2 2025
- New holders
- 57
- 44 more added
- Sold out
- 19
- 48 more reduced
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Price T Rowe Associates Inc | 100,445 | $1.37M | 0.00% | +9,053+9.9% | Added |
| Kennondale Capital Management LLC | 108,615 | $1.48M | 1.13% | +13,450+14.1% | Added |
| Ameriprise Financial Inc | 133,508 | $1.81M | 0.00% | +38,289+40.2% | Added |
| Two Sigma Advisers, LP | 143,000 | $1.94M | 0.00% | −327,000−69.6% | Reduced |
| Bank of Montreal | 143,752 | $1.95M | 0.00% | +240+0.2% | Added |
| Nuveen, LLC | 160,419 | $2.18M | 0.00% | +4,883+3.1% | Added |
| Fred Alger Management, LLC | 164,042 | $2.23M | 0.01% | +164,042 | New |
| Qube Research & Technologies Ltd | 167,106 | $2.27M | 0.00% | −270,920−61.9% | Reduced |
| SummitTX Capital, L.P. | 168,000 | $2.28M | 0.09% | +168,000 | New |
| Bank of New York Mellon Corp | 182,956 | $2.49M | 0.00% | +32,119+21.3% | Added |
| Longaeva Partners L.P. | 200,000 | $2.72M | 0.58% | +200,000 | New |
| Aldebaran Capital, LLC | 204,474 | $2.78M | 2.55% | −13,353−6.1% | Reduced |
| Federated Hermes, Inc. | 212,379 | $2.89M | 0.01% | +8,449+4.1% | Added |
| Trexquant Investment LP | 222,876 | $3.03M | 0.03% | +222,876 | New |
| Citadel Advisors LLC | 234,673 | $3.19M | 0.00% | −1,008,254−81.1% | Reduced |
| Wellington Management Group LLP | 236,197 | $3.21M | 0.00% | −52,421−18.2% | Reduced |
| Polygon Management Ltd. | 258,242 | $3.51M | 0.51% | +39,492+18.1% | Added |
| StemPoint Capital LP | 276,884 | $3.76M | 0.76% | +276,884 | New |
| Patient Square Capital LP | 316,312 | $4.30M | 1.15% | +316,312 | New |
| Falcon Edge Capital, LP | 327,312 | $4.45M | 0.45% | +51,470+18.7% | Added |
| Acuta Capital Partners, LLC | 333,258 | $4.53M | 4.68% | +333,258 | New |
| Acadian Asset Management LLC | 367,331 | $4.99M | 0.01% | −201,752−35.5% | Reduced |
| Barclays PLC | 414,112 | $5.63M | 0.00% | +283,838+217.9% | Added |
| Millennium Management LLC | 417,771 | $5.68M | 0.00% | −1,094,287−72.4% | Reduced |
| Bank of America Corp | 429,516 | $5.84M | 0.00% | −22,292−4.9% | Reduced |
| PFM Health Sciences, LP | 436,156 | $5.93M | 0.51% | −296,100−40.4% | Reduced |
| Ally Bridge Group (NY) LLC | 437,391 | $5.94M | 4.98% | +437,391 | New |
| Rock Springs Capital Management LP | 499,764 | $6.79M | 0.40% | 00.0% | Unchanged |
| Cormorant Asset Management, LP | 500,000 | $6.79M | 0.47% | +500,000 | New |
| Dimensional Fund Advisors LP | 509,780 | $6.94M | 0.00% | +136,041+36.4% | Added |
| Jennison Associates LLC | 578,659 | $7.86M | 0.00% | +578,659 | New |
| Parkman Healthcare Partners LLC | 579,174 | $7.87M | 0.86% | −70,826−10.9% | Reduced |
| Braidwell LP | 612,841 | $8.33M | 0.25% | +612,841 | New |
| Charles Schwab Investment Management Inc | 645,185 | $8.77M | 0.00% | +56,774+9.6% | Added |
| Silverarc Capital Management, LLC | 700,000 | $9.51M | 1.38% | +700,000 | New |
| OrbiMed Advisors LLC | 750,600 | $10.2M | 0.24% | +437,400+139.7% | Added |
| Invesco Ltd. | 810,640 | $11.0M | 0.00% | +223,757+38.1% | Added |
| Northern Trust Corp | 822,237 | $11.2M | 0.00% | +2,073+0.3% | Added |
| Woodline Partners LP | 845,290 | $11.5M | 0.05% | −355,000−29.6% | Reduced |
| ADAR1 Capital Management, LLC | 866,202 | $11.8M | 1.17% | −338,899−28.1% | Reduced |
| Boxer Capital Management, LLC | 900,000 | $12.2M | 3.90% | −325,000−26.5% | Reduced |
| Nantahala Capital Management, LLC | 935,684 | $12.7M | 0.79% | −1,998,721−68.1% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 1,107,008 | $15.0M | 0.05% | −47,477−4.1% | Reduced |
| T. Rowe Price Investment Management, Inc. | 1,198,064 | $16.3M | 0.01% | +1,198,064 | New |
| Deutsche Bank AG | 1,365,521 | $18.6M | 0.01% | +748,602+121.3% | Added |
| UBS Group AG | 1,404,471 | $19.1M | 0.00% | +151,127+12.1% | Added |
| Logos Global Management LP | 1,450,000 | $19.7M | 1.95% | +1,450,000 | New |
| Balyasny Asset Management LLC | 1,476,302 | $20.1M | 0.04% | +1,476,302 | New |
| Eventide Asset Management, LLC | 1,512,500 | $20.6M | 0.34% | +1,512,500 | New |
| State Street Corp | 1,621,260 | $22.0M | 0.00% | +612,351+60.7% | Added |
| Great Point Partners LLC | 1,700,000 | $23.1M | 9.65% | −300,000−15.0% | Reduced |
| 683 Capital Management, LLC | 1,760,000 | $23.9M | 2.17% | −400,000−18.5% | Reduced |
| Geode Capital Management, LLC | 1,812,039 | $24.6M | 0.00% | +119,626+7.1% | Added |
| Paradigm Biocapital Advisors LP | 1,900,000 | $25.8M | 0.76% | +1,900,000 | New |
| Morgan Stanley | 1,950,301 | $26.5M | 0.00% | +1,463,408+300.6% | Added |
| Goldman Sachs Group Inc | 2,010,633 | $27.3M | 0.00% | +712,651+54.9% | Added |
| Almitas Capital LLC | 2,122,597 | $28.8M | 6.60% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 2,420,767 | $32.9M | 0.24% | +1,155,770+91.4% | Added |
| Janus Henderson Group PLC | 2,536,233 | $34.5M | 0.02% | +2,536,233 | New |
| Point72 Asset Management, L.P. | 2,790,066 | $37.9M | 0.08% | −1,746,200−38.5% | Reduced |
| First Light Asset Management, LLC | 3,355,882 | $45.6M | 4.30% | +3,355,882 | New |
| Commodore Capital LP | 4,075,478 | $55.4M | 2.70% | +4,075,478 | New |
| Saturn V Capital Management LLC | 4,604,878 | $62.6M | 13.72% | +1,344,308+41.2% | Added |
| Vanguard Group Inc | 5,273,750 | $71.7M | 0.00% | +775,722+17.2% | Added |
| TCG Crossover Management, LLC | 6,243,812 | $84.9M | 4.17% | +300,000+5.0% | Added |
| Adage Capital Partners GP, L.L.C. | 6,816,828 | $92.6M | 0.15% | −1,983,172−22.5% | Reduced |
| BlackRock, Inc. | 7,140,692 | $97.0M | 0.00% | +1,630,503+29.6% | Added |
| Perceptive Advisors LLC | 8,952,365 | $121.7M | 3.52% | +1,050,000+13.3% | Added |
| FMR LLC | 11,379,207 | $154.6M | 0.01% | +8,331,188+273.3% | Added |
| Standard Life Aberdeen plc | 0 | $0 | 0.00% | −738,657−100.0% | Sold out |
| J. Goldman & Co LP | 0 | $0 | 0.00% | −258,600−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −240,379−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −186,986−100.0% | Sold out |
| American Century Companies Inc | 0 | $0 | 0.00% | −134,380−100.0% | Sold out |
| Allostery Investments LP | 0 | $0 | 0.00% | −120,119−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −110,846−100.0% | Sold out |
| Cantor Fitzgerald, L. P. | 0 | $0 | 0.00% | −50,000−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −47,800−100.0% | Sold out |
| Centiva Capital, LP | 0 | $0 | 0.00% | −45,464−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −40,643−100.0% | Sold out |
| Graham Capital Management, L.P. | 0 | $0 | 0.00% | −34,153−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −25,856−100.0% | Sold out |
| Bridgeway Capital Management, LLC | 0 | $0 | 0.00% | −25,700−100.0% | Sold out |
| Los Angeles Capital Management LLC | 0 | $0 | 0.00% | −23,320−100.0% | Sold out |
| Marex Group plc | 0 | $0 | 0.00% | −20,000−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −12,073−100.0% | Sold out |
| Raymond James Financial Inc | 0 | $0 | 0.00% | −104−100.0% | Sold out |
| Skopos Labs, Inc. | 0 | $0 | 0.00% | −42−100.0% | Sold out |