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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q1 2025

Institutional positions in Xenon Pharmaceuticals Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
206
−3 vs. Q4 2024
Shares held
76.7M
+410.6K (+0.5%) vs. Q4 2024
Total value
$2.58B
−$414.7M (−13.9%) vs. Q4 2024
New holders
20
69 more added
Sold out
23
73 more reduced

Compare with Q4 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2025: 206 institutions
Q1 2021: 91 institutionsQ2 2021: 103 institutionsQ3 2021: 118 institutionsQ4 2021: 130 institutionsQ1 2022: 132 institutionsQ2 2022: 151 institutionsQ3 2022: 154 institutionsQ4 2022: 159 institutionsQ1 2023: 163 institutionsQ2 2023: 175 institutionsQ3 2023: 181 institutionsQ4 2023: 204 institutionsQ1 2024: 220 institutionsQ2 2024: 213 institutionsQ3 2024: 203 institutionsQ4 2024: 209 institutionsQ1 2025: 206 institutionsQ2 2025: 206 institutionsQ3 2025: 219 institutionsQ4 2025: 245 institutionsQ1 2026: 290 institutionsQ2 2026: 315 institutions
Value heldQ1 2025: $2.58B
Q1 2021: $590.0MQ2 2021: $620.0MQ3 2021: $521.7MQ4 2021: $1.49BQ1 2022: $1.50BQ2 2022: $1.73BQ3 2022: $2.09BQ4 2022: $2.38BQ1 2023: $2.19BQ2 2023: $2.36BQ3 2023: $2.10BQ4 2023: $3.32BQ1 2024: $3.16BQ2 2024: $2.89BQ3 2024: $2.95BQ4 2024: $2.99BQ1 2025: $2.58BQ2 2025: $2.60BQ3 2025: $3.39BQ4 2025: $3.78BQ1 2026: $5.80BQ2 2026: $6.10B
Institutions holding XENE and their total value by quarter
QuarterHoldersValue
Q2 2026315$6.10B
Q1 2026290$5.80B
Q4 2025245$3.78B
Q3 2025219$3.39B
Q2 2025206$2.60B
Q1 2025206$2.58B
Q4 2024209$2.99B
Q3 2024203$2.95B
Q2 2024213$2.89B
Q1 2024220$3.16B
Q4 2023204$3.32B
Q3 2023181$2.10B
Q2 2023175$2.36B
Q1 2023163$2.19B
Q4 2022159$2.38B
Q3 2022154$2.09B
Q2 2022151$1.73B
Q1 2022132$1.50B
Q4 2021130$1.49B
Q3 2021118$521.7M
Q2 2021103$620.0M
Q1 202191$590.0M

Institutions, Q1 2025

Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q4 2024.

Institutions holding XENE in Q1 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Capital International Investors3,088,730$103.6M0.02%+541,520+21.3%Added
Janus Henderson Group PLC3,325,093$113.9M0.06%+458,338+16.0%Added
Wellington Management Group LLP3,789,197$127.1M0.02%+11,586+0.3%Added
Driehaus Capital Management LLC4,584,859$153.8M1.48%+64,264+1.4%Added
Avoro Capital Advisors LLC5,741,666$192.6M3.01%+75,000+1.3%Added
FMR LLC8,287,499$278.0M0.02%+762,209+10.1%Added
Proequities, Inc.0$00.00%−2,000−100.0%Sold out
Walleye Capital LLC0$00.00%−221,982−100.0%Sold out
Eversept Partners, LP0$00.00%−155,540−100.0%Sold out
Ikarian Capital, LLC0$00.00%−62,052−100.0%Sold out
LMR Partners LLP0$00.00%−48,668−100.0%Sold out
Woodline Partners LP0$00.00%−39,938−100.0%Sold out
Thrivent Financial for Lutherans0$00.00%−30,699−100.0%Sold out
TD Asset Management Inc0$00.00%−20,430−100.0%Sold out
Brevan Howard Capital Management LP0$00.00%−19,005−100.0%Sold out
Boothbay Fund Management, LLC0$00.00%−17,395−100.0%Sold out
Trexquant Investment LP0$00.00%−11,397−100.0%Sold out
Jane Street Group, LLC0$00.00%−11,138−100.0%Sold out
Tudor Investment Corp Et Al0$00.00%−8,671−100.0%Sold out
Bellevue Group AG0$00.00%−8,200−100.0%Sold out
XTX Topco Ltd0$00.00%−8,054−100.0%Sold out
HRT Financial LP0$00.00%−7,171−100.0%Sold out
Squarepoint Ops LLC0$00.00%−6,554−100.0%Sold out
Magnetar Financial LLC0$00.00%−5,363−100.0%Sold out
Nelson, Van Denburg & Campbell Wealth Management Group, LLC0$00.00%−2,569−100.0%Sold out
Virtus ETF Advisers LLC0$00.00%−1,802−100.0%Sold out
Quadrant Capital Group LLC0$00.00%−66−100.0%Sold out
C M Bidwell & Associates Ltd0$00.00%−9−100.0%Sold out
Hexagon Capital Partners LLC0$00.00%−6−100.0%Sold out