Tyra Biosciences, Inc.
TYRA- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001863127
In the last 90 days, Tyra Biosciences, Inc. insiders filed 1 open-market purchase and 0 sales; 168 institutions reported holding it in 13F filings for Q2 2026, worth $2.22B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Tyra Biosciences, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 116
- −5 vs. Q2 2025
- Shares held
- 55.6M
- −950.0K (−1.7%) vs. Q2 2025
- Total value
- $778.4M
- +$236.9M (+43.7%) vs. Q2 2025
- New holders
- 9
- 40 more added
- Sold out
- 14
- 38 more reduced
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 168 | $2.22B |
| Q1 2026 | 164 | $2.52B |
| Q4 2025 | 133 | $1.49B |
| Q3 2025 | 116 | $778.4M |
| Q2 2025 | 121 | $541.5M |
| Q1 2025 | 117 | $499.5M |
| Q4 2024 | 113 | $675.8M |
| Q3 2024 | 95 | $1.11B |
| Q2 2024 | 79 | $748.6M |
| Q1 2024 | 77 | $768.4M |
| Q4 2023 | 62 | $495.2M |
| Q3 2023 | 59 | $502.1M |
| Q2 2023 | 59 | $616.7M |
| Q1 2023 | 51 | $573.0M |
| Q4 2022 | 46 | $267.8M |
| Q3 2022 | 49 | $313.8M |
| Q2 2022 | 48 | $255.6M |
| Q1 2022 | 46 | $386.6M |
| Q4 2021 | 45 | $494.2M |
| Q3 2021 | 26 | $456.8M |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Tyra Biosciences, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Caligan Partners LP | 696,825 | $9.75M | 1.35% | +506,875+266.8% | Added |
| Balyasny Asset Management LLC | 846,585 | $11.8M | 0.02% | +263,199+45.1% | Added |
| 5AM Venture Management, LLC | 939,298 | $13.1M | 4.81% | 00.0% | Unchanged |
| Farallon Capital Management, L.L.C. | 1,143,818 | $16.0M | 0.09% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,520,185 | $21.3M | 0.00% | +118,492+8.5% | Added |
| BlackRock, Inc. | 1,869,474 | $26.2M | 0.00% | −23,854−1.3% | Reduced |
| Kynam Capital Management, LP | 2,329,998 | $32.6M | 2.43% | 00.0% | Unchanged |
| Vestal Point Capital, LP | 2,425,000 | $33.9M | 1.54% | −230,000−8.7% | Reduced |
| Janus Henderson Group PLC | 2,874,804 | $40.2M | 0.02% | +18,514+0.6% | Added |
| TCG Crossover Management, LLC | 2,898,103 | $40.5M | 1.99% | 00.0% | Unchanged |
| Commodore Capital LP | 3,375,000 | $47.2M | 2.30% | +275,000+8.9% | Added |
| Canaan Partners XI LLC | 3,608,109 | $50.5M | 49.07% | 00.0% | Unchanged |
| BVF Inc | 3,649,794 | $51.1M | 2.07% | −294,400−7.5% | Reduced |
| Nextech Invest, Ltd. | 4,055,861 | $56.7M | 8.64% | 00.0% | Unchanged |
| Alta Partners Management Company, L.P. | 4,080,296 | $57.1M | 95.15% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 12,198,625 | $170.7M | 2.10% | 00.0% | Unchanged |
| OrbiMed Advisors LLC | 0 | $0 | 0.00% | −804,603−100.0% | Sold out |
| AXA S.A. | 0 | $0 | 0.00% | −128,400−100.0% | Sold out |
| Woodline Partners LP | 0 | $0 | 0.00% | −100,108−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −67,442−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −40,939−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −37,782−100.0% | Sold out |
| Dynamic Technology Lab Private Ltd | 0 | $0 | 0.00% | −34,115−100.0% | Sold out |
| Corton Capital Inc. | 0 | $0 | 0.00% | −24,346−100.0% | Sold out |
| Aquatic Capital Management LLC | 0 | $0 | 0.00% | −13,744−100.0% | Sold out |
| Axq Capital, LP | 0 | $0 | 0.00% | −12,350−100.0% | Sold out |
| US Bancorp | 0 | $0 | 0.00% | −7,561−100.0% | Sold out |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | $0 | 0.00% | −3,490−100.0% | Sold out |
| Point72 (DIFC) Ltd | 0 | $0 | 0.00% | −2,330−100.0% | Sold out |
| Caitong International Asset Management Co., Ltd | 0 | $0 | 0.00% | −569−100.0% | Sold out |