Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2024
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 107
- +5 vs. Q1 2024
- Shares held
- 50.4M
- +18.0M (+55.7%) vs. Q1 2024
- Total value
- $1.18B
- −$28.4M (−2.3%) vs. Q1 2024
- New holders
- 29
- 47 more added
- Sold out
- 24
- 17 more reduced
1 institution that held it in Q1 2024 haven't filed for Q2 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2024
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock Inc. | 2,403,441 | $56.5M | 0.00% | +1,846,750+331.7% | Added |
| Braidwell LP | 2,514,538 | $59.1M | 1.85% | +1,999,538+388.3% | Added |
| VR Adviser, LLC | 2,685,448 | $63.1M | 4.02% | +513,666+23.7% | Added |
| Perceptive Advisors LLC | 3,031,018 | $71.3M | 1.72% | +474,339+18.6% | Added |
| RTW Investments, LP | 3,258,360 | $76.6M | 1.19% | +1,025,600+45.9% | Added |
| Fairmount Funds Management LLC | 4,018,101 | $94.5M | 10.67% | +3,639,680+961.8% | Added |
| FMR LLC | 7,507,983 | $176.5M | 0.01% | +924,228+14.0% | Added |
| Fan Yu | 0 | $0 | 0.00% | −737,000−100.0% | Sold out |
| Millennium Management LLC | 0 | $0 | 0.00% | −319,563−100.0% | Sold out |
| Cormorant Asset Management, LP | 0 | $0 | 0.00% | −250,000−100.0% | Sold out |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −161,921−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −101,503−100.0% | Sold out |
| Nicholas Investment Partners, LP | 0 | $0 | 0.00% | −89,962−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −78,996−100.0% | Sold out |
| Assenagon Asset Management S.A. | 0 | $0 | 0.00% | −64,400−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −49,468−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | 0 | $0 | 0.00% | −49,303−100.0% | Sold out |
| Allianz Asset Management GmbH | 0 | $0 | 0.00% | −31,800−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −24,472−100.0% | Sold out |
| Fred Alger Management, LLC | 0 | $0 | 0.00% | −18,158−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −15,653−100.0% | Sold out |
| Scientech Research LLC | 0 | $0 | 0.00% | −13,143−100.0% | Sold out |
| Legato Capital Management LLC | 0 | $0 | 0.00% | −11,458−100.0% | Sold out |
| LMR Partners LLP | 0 | $0 | 0.00% | −11,093−100.0% | Sold out |
| Polymer Capital Management (HK) LTD | 0 | $0 | 0.00% | −10,520−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −8,161−100.0% | Sold out |
| Susquehanna Fundamental Investments, LLC | 0 | $0 | 0.00% | −8,075−100.0% | Sold out |
| Chartwell Investment Partners, LLC | 0 | $0 | 0.00% | −6,835−100.0% | Sold out |
| Arizona State Retirement System | 0 | $0 | 0.00% | −5,445−100.0% | Sold out |
| Point72 (DIFC) Ltd | 0 | $0 | 0.00% | −22−100.0% | Sold out |
| Macquarie Group Ltd | 0 | $0 | 0.00% | −2,523−100.0% | Sold out |
| Credit Suisse AG | – | – | – | – | Not filed |