Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q1 2024
Institutional positions in Spyre Therapeutics, Inc. as of Mar 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 103
- +49 vs. Q4 2023
- Shares held
- 32.4M
- +4.37M (+15.6%) vs. Q4 2023
- Total value
- $1.21B
- +$612.4M (+101.9%) vs. Q4 2023
- New holders
- 55
- 20 more added
- Sold out
- 6
- 15 more reduced
Compare with Q4 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q1 2024
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q4 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| RTW Investments, LP | 2,232,760 | $84.7M | 1.25% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 2,556,679 | $97.0M | 1.71% | −50,000−1.9% | Reduced |
| FMR LLC | 6,583,755 | $246.6M | 0.02% | +2,797,878+73.9% | Added |
| EcoR1 Capital, LLC | 0 | $0 | 0.00% | −887,076−100.0% | Sold out |
| BVF Inc | 0 | $0 | 0.00% | −687,080−100.0% | Sold out |
| University of Notre Dame du Lac | 0 | $0 | 0.00% | −577,616−100.0% | Sold out |
| Prosight Management, LP | 0 | $0 | 0.00% | −55,000−100.0% | Sold out |
| Acadian Asset Management LLC | 0 | $0 | 0.00% | −1,169−100.0% | Sold out |
| Parallel Advisors, LLC | 0 | $0 | 0.00% | −1−100.0% | Sold out |