Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q1 2025
Institutional positions in Spruce Biosciences, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 31
- 0 vs. Q4 2024
- Shares held
- 10.5M
- −728.1K (−6.5%) vs. Q4 2024
- Total value
- $3.03M
- −$1.66M (−35.4%) vs. Q4 2024
- New holders
- 5
- 5 more added
- Sold out
- 5
- 7 more reduced
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Carlyle Group Inc. | 2,896,518 | $840.3K | 0.02% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 2,609,125 | $756.9K | 0.04% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 1,045,828 | $301.0K | 0.00% | 00.0% | Unchanged |
| Ikarian Capital, LLC | 1,000,000 | $290.1K | 0.09% | 00.0% | Unchanged |
| Vanguard Group Inc | 843,844 | $244.7K | 0.00% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 403,716 | $117.1K | 0.02% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 382,900 | $111.1K | 0.00% | −23,000−5.7% | Reduced |
| Boothbay Fund Management, LLC | 288,800 | $83.8K | 0.00% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 276,708 | $80.3K | 0.00% | +2,923+1.1% | Added |
| BlackRock, Inc. | 124,734 | $36.2K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 116,464 | $33.8K | 0.00% | +30,419+35.4% | Added |
| Lion Point Capital, LP | 75,000 | $21.8K | 0.14% | 00.0% | Unchanged |
| State Street Corp | 60,700 | $17.6K | 0.00% | 00.0% | Unchanged |
| Two Sigma Securities, LLC | 47,686 | $13.8K | 0.00% | +47,686 | New |
| XTX Topco Ltd | 41,217 | $12.0K | 0.00% | +5,668+15.9% | Added |
| Shay Capital LLC | 38,119 | $11.1K | 0.00% | 00.0% | Unchanged |
| Virtu Financial LLC | 39,426 | $11.0K | 0.00% | +39,426 | New |
| Jane Street Group, LLC | 37,429 | $10.9K | 0.00% | +37,429 | New |
| Northern Trust Corp | 32,721 | $9.49K | 0.00% | −47,587−59.3% | Reduced |
| Two Sigma Investments, LP | 20,545 | $5.96K | 0.00% | −71−0.3% | Reduced |
| Ground Swell Capital, LLC | 17,312 | $5.02K | 0.01% | +17,312 | New |
| Marex Group plc | 14,800 | $4.29K | 0.00% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 12,200 | $3.54K | 0.00% | −1,600−11.6% | Reduced |
| Citigroup Inc | 11,083 | $3.21K | 0.00% | +11,083 | New |
| Morgan Stanley | 7,396 | $2.15K | 0.00% | +5,263+246.7% | Added |
| Tower Research Capital LLC (TRC) | 4,697 | $1.36K | 0.00% | −64−1.3% | Reduced |
| Group One Trading, L.P. | 1,153 | $334 | 0.00% | −616−34.8% | Reduced |
| Caldwell Sutter Capital, Inc. | 1,000 | $290 | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 233 | $68 | 0.00% | +11+5.0% | Added |
| BNP Paribas Arbitrage, SA | 181 | $52 | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 65 | $19 | 0.00% | −4−5.8% | Reduced |
| Sands Capital Ventures, LLC | 0 | $0 | 0.00% | −715,817−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −58,984−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −37,838−100.0% | Sold out |
| Bridgeway Capital Management, LLC | 0 | $0 | 0.00% | −34,900−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −4,857−100.0% | Sold out |