Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Spruce Biosciences, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 65
- +33 vs. Q1 2026
- Shares held
- 2.15M
- +1.41M (+188.5%) vs. Q1 2026
- Total value
- $116.3M
- +$67.5M (+138.4%) vs. Q1 2026
- New holders
- 37
- 16 more added
- Sold out
- 4
- 3 more reduced
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.8M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.2M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.1M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| AIGH Capital Management LLC | 250,000 | $13.5M | 1.22% | +250,000 | New |
| OrbiMed Advisors LLC | 200,000 | $10.8M | 0.20% | +200,000 | New |
| BlackRock, Inc. | 187,836 | $10.1M | 0.00% | +170,898+1,009.0% | Added |
| Millennium Management LLC | 160,981 | $8.69M | 0.01% | +49,093+43.9% | Added |
| AWM Investment Company, Inc. | 146,988 | $7.94M | 0.69% | +146,988 | New |
| Ikarian Capital, LLC | 121,356 | $6.55M | 1.07% | 00.0% | Unchanged |
| Vanguard Capital Management LLC | 119,331 | $6.44M | 0.00% | +100,994+550.8% | Added |
| Alyeska Investment Group, L.P. | 81,671 | $4.41M | 0.01% | +30,000+58.1% | Added |
| Geode Capital Management, LLC | 70,548 | $3.81M | 0.00% | +57,659+447.4% | Added |
| ADAR1 Capital Management, LLC | 67,717 | $3.66M | 0.17% | +9,117+15.6% | Added |
| Cable Car Capital LLC | 60,000 | $3.24M | 0.07% | +60,000 | New |
| Citadel Advisors LLC | 51,905 | $2.80M | 0.00% | −18,094−25.8% | Reduced |
| State Street Corp | 50,450 | $2.72M | 0.00% | +45,050+834.3% | Added |
| Boothbay Fund Management, LLC | 42,080 | $2.27M | 0.04% | 00.0% | Unchanged |
| StemPoint Capital LP | 41,388 | $2.23M | 0.39% | +28,668+225.4% | Added |
| Eversept Partners, LP | 40,000 | $2.16M | 0.12% | +40,000 | New |
| Carlyle Group Inc. | 38,620 | $2.09M | 0.02% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 32,348 | $1.75M | 0.00% | +26,842+487.5% | Added |
| Diadema Partners LP | 30,000 | $1.62M | 0.57% | +20,000+200.0% | Added |
| Affinity Asset Advisors, LLC | 30,000 | $1.62M | 0.08% | +30,000 | New |
| Stonepine Capital Management, LLC | 28,795 | $1.55M | 1.18% | +28,795 | New |
| Point72 Asset Management, L.P. | 28,278 | $1.53M | 0.00% | +28,278 | New |
| Quinn Opportunity Partners LLC | 26,810 | $1.45M | 0.07% | 00.0% | Unchanged |
| UBS Group AG | 23,381 | $1.26M | 0.00% | +19,462+496.6% | Added |
| ExodusPoint Capital Management, LP | 22,000 | $1.19M | 0.01% | 00.0% | Unchanged |
| Northern Trust Corp | 21,083 | $1.14M | 0.00% | +21,083 | New |
| Rosalind Advisors, Inc. | 20,000 | $1.08M | 0.41% | +20,000 | New |
| Knott David M Jr | 20,000 | $1.08M | 0.57% | +20,000 | New |
| Ameriprise Financial Inc | 18,834 | $1.02M | 0.00% | +18,834 | New |
| Vanguard Portfolio Management LLC | 18,496 | $998.8K | 0.00% | +18,496 | New |
| Vanguard Fiduciary Trust Co | 18,361 | $991.5K | 0.00% | +12,847+233.0% | Added |
| Balyasny Asset Management LLC | 12,138 | $655.5K | 0.00% | −27,862−69.7% | Reduced |
| Dimensional Fund Advisors LP | 8,813 | $476.6K | 0.00% | +8,813 | New |
| Persistent Asset Partners Ltd | 7,677 | $414.6K | 0.13% | +5,149+203.7% | Added |
| State Board of Administration of Florida Retirement System | 7,182 | $387.8K | 0.00% | +7,182 | New |
| Bank of New York Mellon Corp | 6,779 | $366.1K | 0.00% | +6,779 | New |
| Charles Schwab Investment Management Inc | 5,896 | $318.4K | 0.00% | +5,896 | New |
| Renaissance Technologies LLC | 4,700 | $253.8K | 0.00% | +4,700 | New |
| Morgan Stanley | 4,411 | $238.2K | 0.00% | +2,996+211.7% | Added |
| Pale Fire Capital SE | 3,818 | $206.2K | 0.01% | +3,818 | New |
| Rhumbline Advisers | 3,519 | $190.0K | 0.00% | +3,519 | New |
| SkyView Investment Advisors, LLC | 3,000 | $162.0K | 0.13% | +3,000 | New |
| Deutsche Bank AG | 2,652 | $143.2K | 0.00% | +2,652 | New |
| Wells Fargo & Company | 2,329 | $125.8K | 0.00% | +2,329 | New |
| New York State Common Retirement Fund | 1,900 | $102.6K | 0.00% | +1,900 | New |
| Citigroup Inc | 1,265 | $68.3K | 0.00% | +326+34.7% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 1,252 | $67.6K | 0.00% | +1,252 | New |
| JPMorgan Chase & Co | 1,127 | $63.0K | 0.00% | +1,127 | New |
| Lion Point Capital, LP | 1,000 | $54.0K | 0.26% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 864 | $46.7K | 0.00% | +864 | New |
| Barclays PLC | 674 | $36.4K | 0.00% | +674 | New |
| BNP Paribas Arbitrage, SA | 453 | $24.5K | 0.00% | +453 | New |
| Vanguard Global Advisers, LLC | 452 | $24.4K | 0.00% | 00.0% | Unchanged |
| FMR LLC | 343 | $18.5K | 0.00% | +343 | New |
| Legal & General Group Plc | 264 | $14.2K | 0.00% | +264 | New |
| Ameritas Investment Partners, Inc. | 247 | $13.3K | 0.00% | +247 | New |
| Tower Research Capital LLC (TRC) | 246 | $13.3K | 0.00% | +106+75.7% | Added |
| Russell Investments Group, Ltd. | 217 | $11.7K | 0.00% | +217 | New |
| SBI Securities Co., Ltd. | 201 | $10.9K | 0.00% | +201 | New |
| Royal Bank of Canada | 166 | $8.00K | 0.00% | +166 | New |
| Sterling Capital Management LLC | 43 | $2.32K | 0.00% | +43 | New |
| Jones Financial Companies LLLP | 30 | $1.65K | 0.00% | −163−84.5% | Reduced |
| Caldwell Sutter Capital, Inc. | 13 | $702 | 0.00% | 00.0% | Unchanged |
| Friedenthal Financial | 7 | $378 | 0.00% | +7 | New |
| Cassaday & Co Wealth Management LLC | 2 | $108 | 0.00% | 00.0% | Unchanged |
| Wellington Management Group LLP | 0 | $0 | 0.00% | −48,796−100.0% | Sold out |
| Squadron Capital Management LLC | 0 | $0 | 0.00% | −12,200−100.0% | Sold out |
| Resolute Capital Asset Partners LLC | 0 | $0 | 0.00% | −4,000−100.0% | Sold out |
| Sound Income Strategies, LLC | 0 | $0 | 0.00% | −200−100.0% | Sold out |