Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q1 2022
Institutional positions in Spruce Biosciences, Inc. as of Mar 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 43
- −7 vs. Q4 2021
- Shares held
- 17.1M
- −619.8K (−3.5%) vs. Q4 2021
- Total value
- $34.4M
- −$44.6M (−56.5%) vs. Q4 2021
- New holders
- 4
- 8 more added
- Sold out
- 11
- 18 more reduced
Compare with Q4 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q1 2022
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q4 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Novo Holdings A/S | 4,514,336 | $9.07M | 0.48% | 00.0% | Unchanged |
| Omega Fund Management, LLC | 2,161,022 | $4.34M | 0.89% | 00.0% | Unchanged |
| RiverVest Venture Management LLC | 2,148,281 | $4.32M | 4.43% | 00.0% | Unchanged |
| Citadel Advisors LLC | 1,721,846 | $3.46M | 0.00% | −5,255−0.3% | Reduced |
| Rock Springs Capital Management LP | 1,622,689 | $3.26M | 0.08% | 00.0% | Unchanged |
| Aisling Capital Management LP | 1,205,511 | $2.42M | 1.31% | 00.0% | Unchanged |
| Logos Global Management LP | 1,000,000 | $2.01M | 0.26% | −100,000−9.1% | Reduced |
| Sands Capital Ventures, LLC | 787,007 | $1.58M | 0.33% | 00.0% | Unchanged |
| BlackRock Inc. | 529,554 | $1.06M | 0.00% | +109,226+26.0% | Added |
| Bridgeway Capital Management, LLC | 246,327 | $495.0K | 0.01% | +36,463+17.4% | Added |
| State Street Corp | 205,459 | $413.0K | 0.00% | +78,490+61.8% | Added |
| Vanguard Group Inc | 153,736 | $309.0K | 0.00% | −218,391−58.7% | Reduced |
| Geode Capital Management, LLC | 127,028 | $255.0K | 0.00% | −15,441−10.8% | Reduced |
| Bank of New York Mellon Corp | 116,501 | $234.0K | 0.00% | +88,608+317.7% | Added |
| JPMorgan Chase & Co | 113,381 | $227.0K | 0.00% | −4,986−4.2% | Reduced |
| Renaissance Technologies LLC | 111,700 | $225.0K | 0.00% | +71,900+180.7% | Added |
| Northern Trust Corp | 70,687 | $143.0K | 0.00% | −4,324−5.8% | Reduced |
| Goldman Sachs Group Inc | 42,668 | $85.0K | 0.00% | −188,133−81.5% | Reduced |
| Marquette Asset Management, LLC | 40,853 | $82.0K | 0.02% | 00.0% | Unchanged |
| Parametric Portfolio Associates LLC | 27,424 | $55.0K | 0.00% | −37,204−57.6% | Reduced |
| Charles Schwab Investment Management Inc | 18,417 | $38.0K | 0.00% | 00.0% | Unchanged |
| State Board of Administration of Florida Retirement System | 17,440 | $35.0K | 0.00% | 00.0% | Unchanged |
| Cubist Systematic Strategies, LLC | 13,202 | $27.0K | 0.00% | −27,387−67.5% | Reduced |
| Barclays PLC | 12,691 | $25.0K | 0.00% | +12,691 | New |
| Nuveen Asset Management, LLC | 11,643 | $24.0K | 0.00% | 00.0% | Unchanged |
| Deutsche Bank AG | 12,297 | $24.0K | 0.00% | +7,019+133.0% | Added |
| Morgan Stanley | 11,421 | $22.0K | 0.00% | −970−7.8% | Reduced |
| FMR LLC | 6,979 | $14.0K | 0.00% | −107,521−93.9% | Reduced |
| New York State Common Retirement Fund | 6,000 | $12.0K | 0.00% | −91−1.5% | Reduced |
| Tower Research Capital LLC (TRC) | 5,342 | $11.0K | 0.00% | +394+8.0% | Added |
| Bank of America Corp | 4,911 | $10.0K | 0.00% | −78,193−94.1% | Reduced |
| Wells Fargo & Company | 4,852 | $10.0K | 0.00% | −4,623−48.8% | Reduced |
| American International Group, Inc. | 4,312 | $9.00K | 0.00% | −303−6.6% | Reduced |
| UBS Group AG | 3,908 | $8.00K | 0.00% | −1,441−26.9% | Reduced |
| California State Teachers Retirement System | 3,936 | $8.00K | 0.00% | +224+6.0% | Added |
| Point72 Hong Kong Ltd | 2,881 | $6.00K | 0.00% | +2,881 | New |
| Citigroup Inc | 1,186 | $3.00K | 0.00% | −1,021−46.3% | Reduced |
| Legal & General Group Plc | 782 | $2.00K | 0.00% | 00.0% | Unchanged |
| Amalgamated Bank | 1,084 | $2.00K | 0.00% | +1,084 | New |
| Amalgamated Financial Corp. | 1,084 | $2.00K | 0.00% | +1,084 | New |
| Royal Bank of Canada | 633 | $1.00K | 0.00% | −1,143−64.4% | Reduced |
| Ameritas Investment Partners, Inc. | 584 | $1.00K | 0.00% | 00.0% | Unchanged |
| TCI Wealth Advisors, Inc. | 250 | $1.00K | 0.00% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 0 | $0 | 0.00% | −71,756−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −35,953−100.0% | Sold out |
| Bank of Montreal | 0 | $0 | 0.00% | −26,259−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −28,691−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −27,306−100.0% | Sold out |
| Prelude Capital Management, LLC | 0 | $0 | 0.00% | −16,718−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −13,593−100.0% | Sold out |
| Laurion Capital Management LP | 0 | $0 | 0.00% | −11,337−100.0% | Sold out |
| Captrust Financial Advisors | 0 | $0 | 0.00% | −1,477−100.0% | Sold out |
| Capital Advisors, Ltd. LLC | 0 | $0 | 0.00% | −242−100.0% | Sold out |
| Ellevest, Inc. | 0 | $0 | 0.00% | −114−100.0% | Sold out |