Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q2 2021
Institutional positions in Spruce Biosciences, Inc. as of Jun 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 41
- +1 vs. Q1 2021
- Shares held
- 20.1M
- +1.23M (+6.5%) vs. Q1 2021
- Total value
- $225.3M
- −$87.9M (−28.1%) vs. Q1 2021
- New holders
- 5
- 17 more added
- Sold out
- 4
- 12 more reduced
Compare with Q1 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q2 2021
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q1 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Novo Holdings A/S | 4,514,336 | $50.6M | 2.24% | −475,000−9.5% | Reduced |
| Omega Fund Management, LLC | 2,161,022 | $24.2M | 2.74% | 00.0% | Unchanged |
| RiverVest Venture Management LLC | 2,148,281 | $24.1M | 4.71% | 00.0% | Unchanged |
| Deerfield Management Company, L.P. (Series C) | 2,046,958 | $22.9M | 0.41% | +2,046,958 | New |
| Citadel Advisors LLC | 1,703,014 | $19.1M | 0.02% | +2090.0% | Added |
| Rock Springs Capital Management LP | 1,605,001 | $18.0M | 0.36% | +25,700+1.6% | Added |
| Aisling Capital Management LP | 1,205,511 | $13.5M | 2.16% | 00.0% | Unchanged |
| FMR LLC | 1,185,673 | $13.3M | 0.00% | −9,417−0.8% | Reduced |
| Sands Capital Management, LLC | 787,007 | $8.82M | 0.01% | 00.0% | Unchanged |
| Sio Capital Management, LLC | 647,239 | $7.26M | 1.97% | −165,645−20.4% | Reduced |
| BlackRock Inc. | 419,789 | $4.71M | 0.00% | +74,483+21.6% | Added |
| Vanguard Group Inc | 369,520 | $4.14M | 0.00% | +181,003+96.0% | Added |
| Adage Capital Partners GP, L.L.C. | 240,511 | $2.70M | 0.01% | −50,000−17.2% | Reduced |
| JPMorgan Chase & Co | 163,857 | $1.84M | 0.00% | −16,166−9.0% | Reduced |
| Geode Capital Management, LLC | 128,546 | $1.44M | 0.00% | +18,999+17.3% | Added |
| State Street Corp | 124,918 | $1.40M | 0.00% | +30,169+31.8% | Added |
| Morgan Stanley | 122,590 | $1.38M | 0.00% | +88,298+257.5% | Added |
| Granite Point Capital Management, L.P. | 100,000 | $1.12M | 0.33% | 00.0% | Unchanged |
| Caas Capital Management LP | 92,412 | $1.04M | 0.06% | +92,412 | New |
| Northern Trust Corp | 77,864 | $873.0K | 0.00% | +1,720+2.3% | Added |
| Charles Schwab Investment Management Inc | 43,229 | $485.0K | 0.00% | −909−2.1% | Reduced |
| Alps Advisors Inc | 30,726 | $344.0K | 0.00% | +30,726 | New |
| Nuveen Asset Management, LLC | 29,616 | $332.0K | 0.00% | +18,194+159.3% | Added |
| Bank of New York Mellon Corp | 25,566 | $286.0K | 0.00% | +6,386+33.3% | Added |
| Alyeska Investment Group, L.P. | 19,413 | $218.0K | 0.00% | +19,413 | New |
| Millennium Management LLC | 17,216 | $193.0K | 0.00% | −55,865−76.4% | Reduced |
| Laurion Capital Management LP | 14,957 | $168.0K | 0.00% | −5,043−25.2% | Reduced |
| California State Teachers Retirement System | 12,006 | $135.0K | 0.00% | +1,470+14.0% | Added |
| Two Sigma Investments, LP | 11,975 | $134.0K | 0.00% | +11,975 | New |
| Goldman Sachs Group Inc | 10,770 | $121.0K | 0.00% | −1,677−13.5% | Reduced |
| Bank of America Corp | 7,853 | $88.0K | 0.00% | −5,024−39.0% | Reduced |
| Wells Fargo & Company | 7,034 | $79.0K | 0.00% | +4,860+223.6% | Added |
| New York State Common Retirement Fund | 6,059 | $68.0K | 0.00% | +59+1.0% | Added |
| Deutsche Bank AG | 5,185 | $58.0K | 0.00% | +726+16.3% | Added |
| American International Group, Inc. | 4,866 | $55.0K | 0.00% | +806+19.9% | Added |
| STRS Ohio | 2,400 | $26.0K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 933 | $10.0K | 0.00% | +248+36.2% | Added |
| Legal & General Group Plc | 782 | $9.00K | 0.00% | +75+10.6% | Added |
| Royal Bank of Canada | 595 | $7.00K | 0.00% | −202−25.3% | Reduced |
| Ameritas Investment Partners, Inc. | 584 | $7.00K | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 414 | $5.00K | 0.00% | −48−10.4% | Reduced |
| PFM Health Sciences, LP | 0 | $0 | 0.00% | −489,631−100.0% | Sold out |
| ArrowMark Colorado Holdings LLC | 0 | $0 | 0.00% | −128,000−100.0% | Sold out |
| Credit Suisse AG | 0 | $0 | 0.00% | −23,899−100.0% | Sold out |
| Bank of Montreal | 0 | $0 | 0.00% | −216−100.0% | Sold out |