Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q4 2023
Institutional positions in Spruce Biosciences, Inc. as of Dec 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 40
- −1 vs. Q3 2023
- Shares held
- 32.3M
- +369.4K (+1.2%) vs. Q3 2023
- Total value
- $94.4M
- +$22.4M (+31.1%) vs. Q3 2023
- New holders
- 4
- 10 more added
- Sold out
- 5
- 11 more reduced
Compare with Q3 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q4 2023
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q3 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Novo Holdings A/S | 6,722,336 | $19.7M | 1.32% | 00.0% | Unchanged |
| RiverVest Venture Management LLC | 2,936,281 | $8.60M | 31.72% | 00.0% | Unchanged |
| Carlyle Group Inc. | 2,896,518 | $8.37M | 0.40% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 2,609,125 | $7.64M | 0.19% | −119,000−4.4% | Reduced |
| 5AM Venture Management, LLC | 2,364,000 | $6.93M | 1.84% | 00.0% | Unchanged |
| Armistice Capital, LLC | 2,230,000 | $6.53M | 0.17% | −826,000−27.0% | Reduced |
| Omega Fund Management, LLC | 2,161,022 | $6.33M | 5.13% | 00.0% | Unchanged |
| AIGH Capital Management LLC | 2,123,863 | $6.22M | 2.46% | +912,863+75.4% | Added |
| Rosalind Advisors, Inc. | 1,586,392 | $4.65M | 3.89% | +1,586,392 | New |
| Aisling Capital Management LP | 1,205,511 | $3.53M | 1.05% | 00.0% | Unchanged |
| Vanguard Group Inc | 822,390 | $2.41M | 0.00% | +494,121+150.5% | Added |
| Sands Capital Ventures, LLC | 787,007 | $2.31M | 0.64% | 00.0% | Unchanged |
| DAFNA Capital Management LLC | 548,510 | $1.61M | 0.39% | −21,620−3.8% | Reduced |
| Worth Venture Partners, LLC | 526,933 | $1.54M | 0.84% | +224,859+74.4% | Added |
| Millennium Management LLC | 510,441 | $1.50M | 0.00% | −73,031−12.5% | Reduced |
| Alyeska Investment Group, L.P. | 400,000 | $1.17M | 0.01% | −600,000−60.0% | Reduced |
| Acuitas Investments, LLC | 275,085 | $806.0K | 0.42% | +840.0% | Added |
| BlackRock Inc. | 261,016 | $764.8K | 0.00% | +2,515+1.0% | Added |
| Renaissance Technologies LLC | 185,100 | $542.0K | 0.00% | −22,676−10.9% | Reduced |
| Geode Capital Management, LLC | 167,404 | $490.6K | 0.00% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 134,357 | $393.7K | 0.00% | −13,000−8.8% | Reduced |
| Superstring Capital Management LP | 118,814 | $348.1K | 0.25% | +118,814 | New |
| Citadel Advisors LLC | 108,240 | $317.1K | 0.00% | +33,210+44.3% | Added |
| Marshall Wace, LLP | 105,721 | $309.8K | 0.00% | +105,721 | New |
| Northern Trust Corp | 96,688 | $283.3K | 0.00% | +48,024+98.7% | Added |
| Two Sigma Advisers, LP | 95,600 | $280.1K | 0.00% | −700−0.7% | Reduced |
| Bridgeway Capital Management, LLC | 85,000 | $249.1K | 0.01% | 00.0% | Unchanged |
| State Street Corp | 61,993 | $181.6K | 0.00% | 00.0% | Unchanged |
| Marquette Asset Management, LLC | 55,757 | $163.4K | 0.03% | 00.0% | Unchanged |
| Privium Fund Management (UK) Ltd | 24,554 | $71.9K | 0.05% | 00.0% | Unchanged |
| Sofinnova Investments, Inc. | 22,767 | $66.7K | 0.00% | −35,262−60.8% | Reduced |
| Charles Schwab Investment Management Inc | 15,289 | $44.8K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 8,907 | $26.0K | 0.00% | −744−7.7% | Reduced |
| Morgan Stanley | 2,133 | $6.25K | 0.00% | +2+0.1% | Added |
| Caldwell Sutter Capital, Inc. | 1,000 | $2.93K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 485 | $1.42K | 0.00% | +472+3,630.8% | Added |
| Wells Fargo & Company | 141 | $413 | 0.00% | +11+8.5% | Added |
| Bank of America Corp | 13 | $38 | 0.00% | −297−95.8% | Reduced |
| JPMorgan Chase & Co | 11 | $32 | 0.00% | 00.0% | Unchanged |
| Qube Research & Technologies Ltd | 2 | $6 | 0.00% | +2 | New |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −1,319,393−100.0% | Sold out |
| Bank of New York Mellon Corp | 0 | $0 | 0.00% | −89,120−100.0% | Sold out |
| Dimensional Fund Advisors LP | 0 | $0 | 0.00% | −32,452−100.0% | Sold out |
| Tower Research Capital LLC (TRC) | 0 | $0 | 0.00% | −4,356−100.0% | Sold out |
| FMR LLC | 0 | $0 | 0.00% | −36−100.0% | Sold out |