Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Spruce Biosciences, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 32
- +23 vs. Q3 2025
- Shares held
- 753.9K
- −2.18M (−74.3%) vs. Q3 2025
- Total value
- $65.6M
- +$40.5M (+161.0%) vs. Q3 2025
- New holders
- 25
- 4 more added
- Sold out
- 2
- 1 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ikarian Capital, LLC | 121,356 | $10.6M | 1.37% | +108,024+810.3% | Added |
| Squadron Capital Management LLC | 70,000 | $6.10M | 2.72% | +70,000 | New |
| Citadel Advisors LLC | 69,999 | $6.10M | 0.00% | +69,999 | New |
| Wellington Management Group LLP | 58,949 | $5.14M | 0.00% | +58,949 | New |
| ADAR1 Capital Management, LLC | 58,000 | $5.05M | 0.38% | +58,000 | New |
| Alyeska Investment Group, L.P. | 51,671 | $4.50M | 0.01% | +51,671 | New |
| Boothbay Fund Management, LLC | 47,933 | $4.18M | 0.11% | +47,933 | New |
| Balyasny Asset Management LLC | 40,000 | $3.48M | 0.01% | +40,000 | New |
| Carlyle Group Inc. | 38,620 | $3.30M | 0.02% | −2,857,898−98.7% | Reduced |
| ExodusPoint Capital Management, LP | 25,271 | $2.20M | 0.02% | +25,271 | New |
| Schonfeld Strategic Advisors LLC | 24,767 | $2.16M | 0.01% | +24,767 | New |
| Quinn Opportunity Partners LLC | 22,810 | $1.99M | 0.09% | +22,810 | New |
| Caligan Partners LP | 20,514 | $1.79M | 0.16% | +20,514 | New |
| Stonepine Capital Management, LLC | 19,742 | $1.72M | 1.36% | +19,742 | New |
| Vanguard Group Inc | 17,873 | $1.56M | 0.00% | +17,873 | New |
| BlackRock, Inc. | 16,938 | $1.48M | 0.00% | +16,938 | New |
| Geode Capital Management, LLC | 12,732 | $1.11M | 0.00% | +12,732 | New |
| Superstring Capital Management LP | 12,137 | $1.06M | 0.57% | +12,137 | New |
| State Street Corp | 6,400 | $557.5K | 0.00% | +6,400 | New |
| UBS Group AG | 4,902 | $427.0K | 0.00% | +4,770+3,613.6% | Added |
| Resolute Capital Asset Partners LLC | 4,000 | $348.4K | 0.17% | +4,000 | New |
| SkyView Investment Advisors, LLC | 3,000 | $261.0K | 0.03% | +3,000 | New |
| Northern Trust Corp | 2,422 | $211.0K | 0.00% | +2,422 | New |
| BNP Paribas Arbitrage, SA | 2,000 | $174.2K | 0.00% | +2,000 | New |
| Lion Point Capital, LP | 1,000 | $87.1K | 0.45% | 00.0% | Unchanged |
| Morgan Stanley | 388 | $33.8K | 0.00% | +290+295.9% | Added |
| Sound Income Strategies, LLC | 200 | $14.7K | 0.00% | +200 | New |
| Bank of America Corp | 93 | $8.10K | 0.00% | +90+3,000.0% | Added |
| Jones Financial Companies LLLP | 84 | $7.32K | 0.00% | +84 | New |
| Royal Bank of Canada | 40 | $3.00K | 0.00% | +40 | New |
| Caldwell Sutter Capital, Inc. | 13 | $1.13K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 1 | $87 | 0.00% | +1 | New |
| Cable Car Capital LLC | 0 | $0 | 0.00% | −26,666−100.0% | Sold out |
| Advisor Group Holdings, Inc. | 0 | $0 | 0.00% | −133−100.0% | Sold out |