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Livermore
Livermore
ZHEN

Spruce Biosciences, Inc.

SPRB
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001683553

No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.

Holders of 5% or more of SPRB

Holders whose latest Schedule 13D or 13G filing reports 5% or more of Spruce Biosciences, Inc., largest stake first. The change is against the holder's previous filing.

Holders of 5% or more of SPRB
HolderLatest formStakeChangeFirst filedLatest filingFiling
Ikarian Capital, LLC13G/A11.40%121.4K shares−10.20 ppfrom 21.60%Oct 8, 20252 filingsNov 7, 2025SEC
Integrated Core Strategies (US) LLC13G9.60%103.0K sharesNewFeb 24, 20261 filingFeb 24, 2026SEC
Citadel Advisors LLC13G/A6.50%70.0K shares−3.49 ppfrom 9.99%Oct 16, 20252 filingsFeb 17, 2026SEC
Squadron Capital Management LLC13G/A6.50%70.0K shares−0.10 ppfrom 6.60%Oct 15, 20252 filingsFeb 17, 2026SEC
Boone Peter David Mr13G6.40%68.2K sharesNewNov 24, 20251 filingNov 24, 2025SEC
Alyeska Investment Group, L.P.13G5.79%61.7K sharesNewFeb 17, 20261 filingFeb 17, 2026SEC
Wellington Management Group LLP13G5.50%58.9K sharesNewFeb 10, 20261 filingFeb 10, 2026SEC
ADAR1 Capital Management, LLC13G5.40%58.0K sharesNewFeb 17, 20261 filingFeb 17, 2026SEC

Stakes are as of each holder's latest filing. Holders whose last filing was in the old format (before December 18, 2024) have no stake on record and are not listed, and after an acquisition or delisting holders usually stop filing.

13D and 13G filings

17 Schedule 13D and 13G filings on Spruce Biosciences, Inc., newest first, including old-format filings without a stake.

Schedule 13D and 13G filings on SPRB
Filed (ET)FilerFormStakeChangeEvent dateFiling
Feb 24, 20264:47 PM ETIntegrated Core Strategies (US) LLCand 3 others13G9.60%103.0K sharesNewFeb 17, 2026SEC
Feb 18, 20265:27 PM ETCarlyle Group Inc.and 9 others13D/A4.70%50.9K shares–Below 5%Feb 18, 2026SEC
Feb 17, 20268:16 PM ETADAR1 Capital Management, LLCand 1 other13G5.40%58.0K sharesNewDec 31, 2025SEC
Feb 17, 20264:52 PM ETAlyeska Investment Group, L.P.and 2 others13G5.79%61.7K sharesNewDec 31, 2025SEC
Feb 17, 20264:37 PM ETCitadel Advisors LLCand 6 others13G/A6.50%70.0K shares−3.49 ppfrom 9.99%Dec 31, 2025SEC
Feb 17, 202612:27 PM ETSquadron Capital Management LLCand 3 others13G/A6.50%70.0K shares−0.10 ppfrom 6.60%Dec 31, 2025SEC
Feb 10, 202611:19 AM ETWellington Management Group LLPand 2 others13G5.50%58.9K sharesNewDec 31, 2025SEC
Nov 24, 202510:14 AM ETBoone Peter David Mr13G6.40%68.2K sharesNewNov 21, 2025SEC
Nov 7, 20254:30 PM ETIkarian Capital, LLCand 1 other13G/A11.40%121.4K shares−10.20 ppfrom 21.60%Oct 31, 2025SEC
Oct 16, 20255:10 PM ETCitadel Advisors LLCand 6 others13G9.99%109.6K sharesNewOct 9, 2025SEC
Oct 15, 20253:11 PM ETSquadron Capital Management LLCand 3 others13G6.60%70.0K sharesNewOct 8, 2025SEC
Oct 9, 20255:33 PM ETHealthCap VIII, L.P.and 1 other13D/A3.40%36.6K shares–Below 5%Oct 7, 2025SEC
Oct 8, 202511:04 AM ETIkarian Capital, LLCand 1 other13G21.60%121.4K sharesNewOct 6, 2025SEC
Aug 13, 20254:31 PM ETRock Springs Capital Management LPand 4 others13G/A0.00%0 shares–Below 5%Jul 3, 2025SEC
Aug 13, 20254:26 PM ETRadoff Bradley Louisand 1 other13G/A0.00%0 shares–Below 5%Jun 30, 2025SEC
Feb 13, 202512:50 PM ETRosalind Advisors, Inc.and 3 others13G/A0.00%0 shares–Below 5%Dec 31, 2024SEC
Jan 10, 202511:05 AM ETRiverVest Venture Fund III, L.P.and 11 others13D/A4.20%1.76M shares–Below 5%Jan 7, 2025SEC

Form 144: proposed insider sales

Notices from officers, directors and other affiliates planning to sell Spruce Biosciences, Inc. shares.

No Form 144 notices for Spruce Biosciences, Inc. are on file.