Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q1 2024
Institutional positions in Spruce Biosciences, Inc. as of Mar 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 50
- +10 vs. Q4 2023
- Shares held
- 18.0M
- −14.3M (−44.3%) vs. Q4 2023
- Total value
- $14.1M
- −$80.3M (−85.0%) vs. Q4 2023
- New holders
- 22
- 10 more added
- Sold out
- 12
- 8 more reduced
Compare with Q4 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q1 2024
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q4 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| RiverVest Venture Management LLC | 2,936,281 | $2.31M | 28.35% | 00.0% | Unchanged |
| Carlyle Group Inc. | 2,896,518 | $2.28M | 0.14% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 2,609,125 | $2.05M | 0.05% | 00.0% | Unchanged |
| Rosalind Advisors, Inc. | 1,508,419 | $1.19M | 1.11% | −77,973−4.9% | Reduced |
| Aisling Capital Management LP | 1,205,511 | $947.5K | 0.32% | 00.0% | Unchanged |
| Altium Capital Management LP | 1,150,000 | $903.8K | 0.40% | +1,150,000 | New |
| Vanguard Group Inc | 863,375 | $678.5K | 0.00% | +40,985+5.0% | Added |
| Sands Capital Ventures, LLC | 787,007 | $621.7K | 0.15% | 00.0% | Unchanged |
| Superstring Capital Management LP | 440,225 | $346.0K | 0.23% | +321,411+270.5% | Added |
| Acadian Asset Management LLC | 368,831 | $289.0K | 0.00% | +368,831 | New |
| ADAR1 Capital Management, LLC | 365,216 | $287.0K | 0.08% | +365,216 | New |
| Renaissance Technologies LLC | 271,000 | $213.0K | 0.00% | +85,900+46.4% | Added |
| Panagora Asset Management Inc | 253,682 | $199.4K | 0.00% | +253,682 | New |
| ExodusPoint Capital Management, LP | 224,833 | $177.0K | 0.00% | +224,833 | New |
| Geode Capital Management, LLC | 200,162 | $157.3K | 0.00% | +32,758+19.6% | Added |
| AWM Investment Company, Inc. | 200,000 | $157.2K | 0.02% | +200,000 | New |
| BlackRock Inc. | 185,948 | $146.1K | 0.00% | −75,068−28.8% | Reduced |
| Walleye Capital LLC | 178,958 | $140.6K | 0.00% | +178,958 | New |
| Two Sigma Investments, LP | 123,013 | $96.7K | 0.00% | −11,344−8.4% | Reduced |
| Millennium Management LLC | 102,223 | $80.3K | 0.00% | −408,218−80.0% | Reduced |
| Two Sigma Advisers, LP | 90,300 | $71.0K | 0.00% | −5,300−5.5% | Reduced |
| Citadel Advisors LLC | 87,877 | $69.1K | 0.00% | −20,363−18.8% | Reduced |
| Bridgeway Capital Management, LLC | 85,000 | $66.8K | 0.00% | 00.0% | Unchanged |
| Jane Street Group, LLC | 78,544 | $61.7K | 0.00% | +78,544 | New |
| Lion Point Capital, LP | 75,000 | $58.9K | 0.11% | +75,000 | New |
| Northern Trust Corp | 74,955 | $58.9K | 0.00% | −21,733−22.5% | Reduced |
| Marshall Wace, LLP | 72,245 | $57.1K | 0.00% | −33,476−31.7% | Reduced |
| State Street Corp | 64,400 | $50.6K | 0.00% | +2,407+3.9% | Added |
| Castleview Partners, LLC | 59,709 | $46.9K | 0.03% | +59,709 | New |
| XTX Topco Ltd | 56,747 | $44.6K | 0.01% | +56,747 | New |
| Dimensional Fund Advisors LP | 46,664 | $36.7K | 0.00% | +46,664 | New |
| Qube Research & Technologies Ltd | 39,596 | $27.7K | 0.00% | +39,594+1,979,700.0% | Added |
| Susquehanna International Group, LLP | 29,709 | $23.3K | 0.00% | +29,709 | New |
| Simplex Trading, LLC | 28,100 | $22.0K | 0.00% | +28,100 | New |
| Bank of America Corp | 26,130 | $20.5K | 0.00% | +26,117+200,900.0% | Added |
| Two Sigma Securities, LLC | 26,016 | $20.4K | 0.00% | +26,016 | New |
| Privium Fund Management (UK) Ltd | 24,554 | $20.1K | 0.01% | 00.0% | Unchanged |
| Belvedere Trading LLC | 24,900 | $19.6K | 0.00% | +24,900 | New |
| Balyasny Asset Management LLC | 22,508 | $17.7K | 0.00% | +22,508 | New |
| Morgan Stanley | 21,523 | $16.9K | 0.00% | +19,390+909.0% | Added |
| Omers Administration Corp | 16,000 | $12.6K | 0.00% | +16,000 | New |
| UBS Group AG | 15,814 | $12.4K | 0.00% | +15,329+3,160.6% | Added |
| Charles Schwab Investment Management Inc | 15,289 | $12.0K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 11,427 | $8.98K | 0.00% | +11,427 | New |
| Group One Trading, L.P. | 3,939 | $3.10K | 0.00% | +3,939 | New |
| Caldwell Sutter Capital, Inc. | 1,000 | $786 | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 143 | $112 | 0.00% | +2+1.4% | Added |
| FMR LLC | 103 | $81 | 0.00% | +103 | New |
| JPMorgan Chase & Co | 11 | $9 | 0.00% | 00.0% | Unchanged |
| Macquarie Group Ltd | 362 | $0 | 0.00% | +362 | New |
| Novo Holdings A/S | 0 | $0 | 0.00% | −6,722,336−100.0% | Sold out |
| 5AM Venture Management, LLC | 0 | $0 | 0.00% | −2,364,000−100.0% | Sold out |
| Armistice Capital, LLC | 0 | $0 | 0.00% | −2,230,000−100.0% | Sold out |
| Omega Fund Management, LLC | 0 | $0 | 0.00% | −2,161,022−100.0% | Sold out |
| AIGH Capital Management LLC | 0 | $0 | 0.00% | −2,123,863−100.0% | Sold out |
| DAFNA Capital Management LLC | 0 | $0 | 0.00% | −548,510−100.0% | Sold out |
| Worth Venture Partners, LLC | 0 | $0 | 0.00% | −526,933−100.0% | Sold out |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −400,000−100.0% | Sold out |
| Acuitas Investments, LLC | 0 | $0 | 0.00% | −275,085−100.0% | Sold out |
| Marquette Asset Management, LLC | 0 | $0 | 0.00% | −55,757−100.0% | Sold out |
| Sofinnova Investments, Inc. | 0 | $0 | 0.00% | −22,767−100.0% | Sold out |
| Royal Bank of Canada | 0 | $0 | 0.00% | −8,907−100.0% | Sold out |