Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q1 2024
Institutional positions in Spruce Biosciences, Inc. as of Mar 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 50
- +10 vs. Q4 2023
- Shares held
- 18.0M
- −14.3M (−44.3%) vs. Q4 2023
- Total value
- $14.1M
- −$80.3M (−85.0%) vs. Q4 2023
- New holders
- 22
- 10 more added
- Sold out
- 12
- 8 more reduced
Compare with Q4 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q1 2024
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q4 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Macquarie Group Ltd | 362 | $0 | 0.00% | +362 | New |
| JPMorgan Chase & Co | 11 | $9 | 0.00% | 00.0% | Unchanged |
| FMR LLC | 103 | $81 | 0.00% | +103 | New |
| Wells Fargo & Company | 143 | $112 | 0.00% | +2+1.4% | Added |
| Caldwell Sutter Capital, Inc. | 1,000 | $786 | 0.00% | 00.0% | Unchanged |
| Group One Trading, L.P. | 3,939 | $3.10K | 0.00% | +3,939 | New |
| Tower Research Capital LLC (TRC) | 11,427 | $8.98K | 0.00% | +11,427 | New |
| Charles Schwab Investment Management Inc | 15,289 | $12.0K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 15,814 | $12.4K | 0.00% | +15,329+3,160.6% | Added |
| Omers Administration Corp | 16,000 | $12.6K | 0.00% | +16,000 | New |
| Morgan Stanley | 21,523 | $16.9K | 0.00% | +19,390+909.0% | Added |
| Balyasny Asset Management LLC | 22,508 | $17.7K | 0.00% | +22,508 | New |
| Belvedere Trading LLC | 24,900 | $19.6K | 0.00% | +24,900 | New |
| Privium Fund Management (UK) Ltd | 24,554 | $20.1K | 0.01% | 00.0% | Unchanged |
| Two Sigma Securities, LLC | 26,016 | $20.4K | 0.00% | +26,016 | New |
| Bank of America Corp | 26,130 | $20.5K | 0.00% | +26,117+200,900.0% | Added |
| Simplex Trading, LLC | 28,100 | $22.0K | 0.00% | +28,100 | New |
| Susquehanna International Group, LLP | 29,709 | $23.3K | 0.00% | +29,709 | New |
| Qube Research & Technologies Ltd | 39,596 | $27.7K | 0.00% | +39,594+1,979,700.0% | Added |
| Dimensional Fund Advisors LP | 46,664 | $36.7K | 0.00% | +46,664 | New |
| XTX Topco Ltd | 56,747 | $44.6K | 0.01% | +56,747 | New |
| Castleview Partners, LLC | 59,709 | $46.9K | 0.03% | +59,709 | New |
| State Street Corp | 64,400 | $50.6K | 0.00% | +2,407+3.9% | Added |
| Marshall Wace, LLP | 72,245 | $57.1K | 0.00% | −33,476−31.7% | Reduced |
| Northern Trust Corp | 74,955 | $58.9K | 0.00% | −21,733−22.5% | Reduced |
| Lion Point Capital, LP | 75,000 | $58.9K | 0.11% | +75,000 | New |
| Jane Street Group, LLC | 78,544 | $61.7K | 0.00% | +78,544 | New |
| Bridgeway Capital Management, LLC | 85,000 | $66.8K | 0.00% | 00.0% | Unchanged |
| Citadel Advisors LLC | 87,877 | $69.1K | 0.00% | −20,363−18.8% | Reduced |
| Two Sigma Advisers, LP | 90,300 | $71.0K | 0.00% | −5,300−5.5% | Reduced |
| Millennium Management LLC | 102,223 | $80.3K | 0.00% | −408,218−80.0% | Reduced |
| Two Sigma Investments, LP | 123,013 | $96.7K | 0.00% | −11,344−8.4% | Reduced |
| Walleye Capital LLC | 178,958 | $140.6K | 0.00% | +178,958 | New |
| BlackRock Inc. | 185,948 | $146.1K | 0.00% | −75,068−28.8% | Reduced |
| AWM Investment Company, Inc. | 200,000 | $157.2K | 0.02% | +200,000 | New |
| Geode Capital Management, LLC | 200,162 | $157.3K | 0.00% | +32,758+19.6% | Added |
| ExodusPoint Capital Management, LP | 224,833 | $177.0K | 0.00% | +224,833 | New |
| Panagora Asset Management Inc | 253,682 | $199.4K | 0.00% | +253,682 | New |
| Renaissance Technologies LLC | 271,000 | $213.0K | 0.00% | +85,900+46.4% | Added |
| ADAR1 Capital Management, LLC | 365,216 | $287.0K | 0.08% | +365,216 | New |
| Acadian Asset Management LLC | 368,831 | $289.0K | 0.00% | +368,831 | New |
| Superstring Capital Management LP | 440,225 | $346.0K | 0.23% | +321,411+270.5% | Added |
| Sands Capital Ventures, LLC | 787,007 | $621.7K | 0.15% | 00.0% | Unchanged |
| Vanguard Group Inc | 863,375 | $678.5K | 0.00% | +40,985+5.0% | Added |
| Altium Capital Management LP | 1,150,000 | $903.8K | 0.40% | +1,150,000 | New |
| Aisling Capital Management LP | 1,205,511 | $947.5K | 0.32% | 00.0% | Unchanged |
| Rosalind Advisors, Inc. | 1,508,419 | $1.19M | 1.11% | −77,973−4.9% | Reduced |
| Rock Springs Capital Management LP | 2,609,125 | $2.05M | 0.05% | 00.0% | Unchanged |
| Carlyle Group Inc. | 2,896,518 | $2.28M | 0.14% | 00.0% | Unchanged |
| RiverVest Venture Management LLC | 2,936,281 | $2.31M | 28.35% | 00.0% | Unchanged |
| Novo Holdings A/S | 0 | $0 | 0.00% | −6,722,336−100.0% | Sold out |
| 5AM Venture Management, LLC | 0 | $0 | 0.00% | −2,364,000−100.0% | Sold out |
| Armistice Capital, LLC | 0 | $0 | 0.00% | −2,230,000−100.0% | Sold out |
| Omega Fund Management, LLC | 0 | $0 | 0.00% | −2,161,022−100.0% | Sold out |
| AIGH Capital Management LLC | 0 | $0 | 0.00% | −2,123,863−100.0% | Sold out |
| DAFNA Capital Management LLC | 0 | $0 | 0.00% | −548,510−100.0% | Sold out |
| Worth Venture Partners, LLC | 0 | $0 | 0.00% | −526,933−100.0% | Sold out |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −400,000−100.0% | Sold out |
| Acuitas Investments, LLC | 0 | $0 | 0.00% | −275,085−100.0% | Sold out |
| Marquette Asset Management, LLC | 0 | $0 | 0.00% | −55,757−100.0% | Sold out |
| Sofinnova Investments, Inc. | 0 | $0 | 0.00% | −22,767−100.0% | Sold out |
| Royal Bank of Canada | 0 | $0 | 0.00% | −8,907−100.0% | Sold out |