Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Spruce Biosciences, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 3
- −28 vs. Q1 2025
- Shares held
- 2.05M
- −8.40M (−80.4%) vs. Q1 2025
- Total value
- $146.6K
- −$2.88M (−95.2%) vs. Q1 2025
- New holders
- 0
- 0 more added
- Sold out
- 28
- 0 more reduced
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Acadian Asset Management LLC | 1,045,828 | $74.0K | 0.00% | 00.0% | Unchanged |
| Ikarian Capital, LLC | 1,000,000 | $72.5K | 0.02% | 00.0% | Unchanged |
| Caldwell Sutter Capital, Inc. | 1,000 | $73 | 0.00% | 00.0% | Unchanged |
| Carlyle Group Inc. | 0 | $0 | 0.00% | −2,896,518−100.0% | Sold out |
| Rock Springs Capital Management LP | 0 | $0 | 0.00% | −2,609,125−100.0% | Sold out |
| Vanguard Group Inc | 0 | $0 | 0.00% | −843,844−100.0% | Sold out |
| ADAR1 Capital Management, LLC | 0 | $0 | 0.00% | −403,716−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −382,900−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −288,800−100.0% | Sold out |
| Geode Capital Management, LLC | 0 | $0 | 0.00% | −276,708−100.0% | Sold out |
| BlackRock, Inc. | 0 | $0 | 0.00% | −124,734−100.0% | Sold out |
| UBS Group AG | 0 | $0 | 0.00% | −116,464−100.0% | Sold out |
| Lion Point Capital, LP | 0 | $0 | 0.00% | −75,000−100.0% | Sold out |
| State Street Corp | 0 | $0 | 0.00% | −60,700−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −47,686−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −41,217−100.0% | Sold out |
| Shay Capital LLC | 0 | $0 | 0.00% | −38,119−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −39,426−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −37,429−100.0% | Sold out |
| Northern Trust Corp | 0 | $0 | 0.00% | −32,721−100.0% | Sold out |
| Two Sigma Investments, LP | 0 | $0 | 0.00% | −20,545−100.0% | Sold out |
| Ground Swell Capital, LLC | 0 | $0 | 0.00% | −17,312−100.0% | Sold out |
| Marex Group plc | 0 | $0 | 0.00% | −14,800−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −12,200−100.0% | Sold out |
| Citigroup Inc | 0 | $0 | 0.00% | −11,083−100.0% | Sold out |
| Morgan Stanley | 0 | $0 | 0.00% | −7,396−100.0% | Sold out |
| Tower Research Capital LLC (TRC) | 0 | $0 | 0.00% | −4,697−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −1,153−100.0% | Sold out |
| Bank of America Corp | 0 | $0 | 0.00% | −233−100.0% | Sold out |
| BNP Paribas Arbitrage, SA | 0 | $0 | 0.00% | −181−100.0% | Sold out |
| JPMorgan Chase & Co | 0 | $0 | 0.00% | −65−100.0% | Sold out |