Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q2 2023
Institutional positions in Spruce Biosciences, Inc. as of Jun 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 39
- −5 vs. Q1 2023
- Shares held
- 32.0M
- −1.79M (−5.3%) vs. Q1 2023
- Total value
- $68.7M
- −$5.80M (−7.8%) vs. Q1 2023
- New holders
- 4
- 11 more added
- Sold out
- 9
- 11 more reduced
Compare with Q1 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q2 2023
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q1 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Novo Holdings A/S | 6,722,336 | $14.5M | 1.12% | 00.0% | Unchanged |
| Armistice Capital, LLC | 3,498,000 | $7.52M | 0.19% | −430,000−10.9% | Reduced |
| RiverVest Venture Management LLC | 2,936,281 | $6.31M | 7.00% | 00.0% | Unchanged |
| Carlyle Group Inc. | 2,896,518 | $6.23M | 0.22% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 2,728,125 | $5.87M | 0.14% | 00.0% | Unchanged |
| 5AM Venture Management, LLC | 2,364,000 | $5.08M | 1.27% | 00.0% | Unchanged |
| Omega Fund Management, LLC | 2,161,022 | $4.65M | 2.60% | 00.0% | Unchanged |
| Aisling Capital Management LP | 1,205,511 | $2.59M | 1.27% | 00.0% | Unchanged |
| AIGH Capital Management LLC | 1,111,000 | $2.39M | 0.98% | +7,000+0.6% | Added |
| Verition Fund Management LLC | 1,083,730 | $2.33M | 0.04% | +121,831+12.7% | Added |
| Alyeska Investment Group, L.P. | 1,000,000 | $2.15M | 0.02% | 00.0% | Unchanged |
| Sands Capital Ventures, LLC | 787,007 | $1.69M | 0.50% | 00.0% | Unchanged |
| Millennium Management LLC | 577,658 | $1.24M | 0.00% | −31,187−5.1% | Reduced |
| DAFNA Capital Management LLC | 312,000 | $670.8K | 0.18% | 00.0% | Unchanged |
| Worth Venture Partners, LLC | 277,624 | $596.9K | 0.33% | +7,000+2.6% | Added |
| Acuitas Investments, LLC | 275,006 | $591.3K | 0.34% | +275,006 | New |
| Vanguard Group Inc | 261,954 | $563.2K | 0.00% | +15,376+6.2% | Added |
| BlackRock Inc. | 260,979 | $561.1K | 0.00% | +109,666+72.5% | Added |
| Two Sigma Advisers, LP | 240,000 | $516.0K | 0.00% | +202,400+538.3% | Added |
| Renaissance Technologies LLC | 239,099 | $514.0K | 0.00% | +78,999+49.3% | Added |
| Two Sigma Investments, LP | 228,130 | $490.5K | 0.00% | +64,965+39.8% | Added |
| Geode Capital Management, LLC | 217,911 | $468.5K | 0.00% | +157,290+259.5% | Added |
| Bank of New York Mellon Corp | 91,455 | $196.6K | 0.00% | −622−0.7% | Reduced |
| Bridgeway Capital Management, LLC | 85,000 | $182.8K | 0.00% | 00.0% | Unchanged |
| Citadel Advisors LLC | 71,277 | $153.2K | 0.00% | −1,627,341−95.8% | Reduced |
| State Street Corp | 58,793 | $126.4K | 0.00% | −34,307−36.8% | Reduced |
| Sofinnova Investments, Inc. | 58,029 | $124.8K | 0.01% | +58,029 | New |
| Northern Trust Corp | 57,097 | $122.8K | 0.00% | +43,356+315.5% | Added |
| Marquette Asset Management, LLC | 55,757 | $119.9K | 0.03% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 32,440 | $69.7K | 0.00% | −6,728−17.2% | Reduced |
| Privium Fund Management (UK) Ltd | 24,554 | $52.1K | 0.04% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 23,560 | $50.7K | 0.00% | −34,619−59.5% | Reduced |
| Charles Schwab Investment Management Inc | 15,289 | $32.9K | 0.00% | +15,289 | New |
| Tower Research Capital LLC (TRC) | 2,358 | $5.07K | 0.00% | −1,522−39.2% | Reduced |
| Royal Bank of Canada | 2,531 | $5.00K | 0.00% | −91,389−97.3% | Reduced |
| Morgan Stanley | 2,131 | $4.58K | 0.00% | −1,019−32.3% | Reduced |
| Caldwell Sutter Capital, Inc. | 1,000 | $2.15K | 0.00% | +1,000 | New |
| Wells Fargo & Company | 186 | $400 | 0.00% | +119+177.6% | Added |
| UBS Group AG | 13 | $28 | 0.00% | −947−98.6% | Reduced |
| CVI Holdings, LLC | 0 | $0 | 0.00% | −472,000−100.0% | Sold out |
| Goldman Sachs Group Inc | 0 | $0 | 0.00% | −182,656−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −13,722−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −13,340−100.0% | Sold out |
| Barclays PLC | 0 | $0 | 0.00% | −7,484−100.0% | Sold out |
| Federated Hermes, Inc. | 0 | $0 | 0.00% | −1,032−100.0% | Sold out |
| TCI Wealth Advisors, Inc. | 0 | $0 | 0.00% | −250−100.0% | Sold out |
| Bank of America Corp | 0 | $0 | 0.00% | −249−100.0% | Sold out |
| FMR LLC | 0 | $0 | 0.00% | −50−100.0% | Sold out |