Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q4 2024
Institutional positions in Spruce Biosciences, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 31
- +2 vs. Q3 2024
- Shares held
- 11.2M
- +502.2K (+4.7%) vs. Q3 2024
- Total value
- $4.69M
- −$320.0K (−6.4%) vs. Q3 2024
- New holders
- 6
- 5 more added
- Sold out
- 4
- 10 more reduced
1 institution that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Carlyle Group Inc. | 2,896,518 | $1.22M | 0.03% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 2,609,125 | $1.10M | 0.04% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 1,045,828 | $437.0K | 0.00% | −213,323−16.9% | Reduced |
| Ikarian Capital, LLC | 1,000,000 | $420.0K | 0.12% | +1,000,000 | New |
| Vanguard Group Inc | 843,844 | $354.4K | 0.00% | 00.0% | Unchanged |
| Sands Capital Ventures, LLC | 715,817 | $300.6K | 0.07% | −71,190−9.0% | Reduced |
| Renaissance Technologies LLC | 405,900 | $170.5K | 0.00% | −203,800−33.4% | Reduced |
| ADAR1 Capital Management, LLC | 403,716 | $169.6K | 0.03% | 00.0% | Unchanged |
| Boothbay Fund Management, LLC | 288,800 | $121.3K | 0.00% | +288,800 | New |
| Geode Capital Management, LLC | 273,785 | $115.0K | 0.00% | +11,837+4.5% | Added |
| BlackRock, Inc. | 124,734 | $52.4K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 86,045 | $36.1K | 0.00% | +86,032+661,784.6% | Added |
| Northern Trust Corp | 80,308 | $33.7K | 0.00% | +5,381+7.2% | Added |
| Lion Point Capital, LP | 75,000 | $31.5K | 0.16% | 00.0% | Unchanged |
| State Street Corp | 60,700 | $25.5K | 0.00% | −3,700−5.7% | Reduced |
| Susquehanna International Group, LLP | 58,984 | $24.8K | 0.00% | +58,984 | New |
| Shay Capital LLC | 38,119 | $16.0K | 0.00% | 00.0% | Unchanged |
| HRT Financial LP | 37,838 | $15.0K | 0.00% | +37,838 | New |
| XTX Topco Ltd | 35,549 | $14.9K | 0.00% | +16,415+85.8% | Added |
| Bridgeway Capital Management, LLC | 34,900 | $14.7K | 0.00% | −5,100−12.8% | Reduced |
| Two Sigma Investments, LP | 20,616 | $8.66K | 0.00% | −2,752−11.8% | Reduced |
| Marex Group plc | 14,800 | $6.22K | 0.00% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 13,800 | $5.80K | 0.00% | −13,300−49.1% | Reduced |
| Tower Research Capital LLC (TRC) | 4,761 | $2.00K | 0.00% | +111+2.4% | Added |
| Simplex Trading, LLC | 4,857 | $2.00K | 0.00% | +4,857 | New |
| Morgan Stanley | 2,133 | $896 | 0.00% | 00.0% | Unchanged |
| Group One Trading, L.P. | 1,769 | $743 | 0.00% | −2,070−53.9% | Reduced |
| Caldwell Sutter Capital, Inc. | 1,000 | $420 | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 222 | $93 | 0.00% | −1−0.4% | Reduced |
| BNP Paribas Arbitrage, SA | 181 | $76 | 0.00% | +181 | New |
| JPMorgan Chase & Co | 69 | $29 | 0.00% | −2−2.8% | Reduced |
| Almitas Capital LLC | 0 | $0 | 0.00% | −396,506−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −77,053−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −15,658−100.0% | Sold out |
| Royal Bank of Canada | 0 | $0 | 0.00% | −3,733−100.0% | Sold out |
| RiverVest Venture Management LLC | – | – | – | – | Not filed |