Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Spruce Biosciences, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 32
- +1 vs. Q4 2025
- Shares held
- 739.8K
- +3.78K (+0.5%) vs. Q4 2025
- Total value
- $48.3M
- −$15.7M (−24.5%) vs. Q4 2025
- New holders
- 10
- 6 more added
- Sold out
- 9
- 6 more reduced
1 institution that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ikarian Capital, LLC | 121,356 | $7.93M | 1.13% | 00.0% | Unchanged |
| Millennium Management LLC | 111,888 | $7.31M | 0.01% | +111,888 | New |
| Citadel Advisors LLC | 69,999 | $4.57M | 0.00% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 58,600 | $3.83M | 0.23% | +600+1.0% | Added |
| Alyeska Investment Group, L.P. | 51,671 | $3.38M | 0.01% | 00.0% | Unchanged |
| Wellington Management Group LLP | 48,796 | $3.19M | 0.00% | −10,153−17.2% | Reduced |
| Boothbay Fund Management, LLC | 42,080 | $2.75M | 0.06% | −5,853−12.2% | Reduced |
| Balyasny Asset Management LLC | 40,000 | $2.61M | 0.01% | 00.0% | Unchanged |
| Carlyle Group Inc. | 38,620 | $2.52M | 0.02% | 00.0% | Unchanged |
| Quinn Opportunity Partners LLC | 26,810 | $1.75M | 0.09% | +4,000+17.5% | Added |
| ExodusPoint Capital Management, LP | 22,000 | $1.44M | 0.01% | −3,271−12.9% | Reduced |
| Vanguard Capital Management LLC | 18,337 | $1.20M | 0.00% | +18,337 | New |
| BlackRock, Inc. | 16,938 | $1.11M | 0.00% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 12,889 | $842.7K | 0.00% | +157+1.2% | Added |
| Squadron Capital Management LLC | 12,200 | $797.3K | 0.32% | −57,800−82.6% | Reduced |
| Diadema Partners LP | 10,000 | $653.5K | 0.27% | +10,000 | New |
| StemPoint Capital LP | 6,360 | $415.6K | 0.08% | +6,360 | New |
| Vanguard Fiduciary Trust Co | 5,514 | $360.3K | 0.00% | +5,514 | New |
| Goldman Sachs Group Inc | 5,506 | $359.8K | 0.00% | +5,506 | New |
| State Street Corp | 5,400 | $352.9K | 0.00% | −1,000−15.6% | Reduced |
| Resolute Capital Asset Partners LLC | 4,000 | $261.4K | 0.14% | 00.0% | Unchanged |
| UBS Group AG | 3,919 | $256.1K | 0.00% | −983−20.1% | Reduced |
| Persistent Asset Partners Ltd | 2,528 | $165.2K | 0.06% | +2,528 | New |
| Morgan Stanley | 1,415 | $92.5K | 0.00% | +1,027+264.7% | Added |
| Lion Point Capital, LP | 1,000 | $65.3K | 0.39% | 00.0% | Unchanged |
| Citigroup Inc | 939 | $61.4K | 0.00% | +939 | New |
| Vanguard Global Advisers, LLC | 452 | $29.5K | 0.00% | +452 | New |
| Sound Income Strategies, LLC | 200 | $13.9K | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 193 | $12.2K | 0.00% | +109+129.8% | Added |
| Tower Research Capital LLC (TRC) | 140 | $9.15K | 0.00% | +139+13,900.0% | Added |
| Caldwell Sutter Capital, Inc. | 13 | $850 | 0.00% | 00.0% | Unchanged |
| Cassaday & Co Wealth Management LLC | 2 | $130 | 0.00% | +2 | New |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −24,767−100.0% | Sold out |
| Caligan Partners LP | 0 | $0 | 0.00% | −20,514−100.0% | Sold out |
| Stonepine Capital Management, LLC | 0 | $0 | 0.00% | −19,742−100.0% | Sold out |
| Superstring Capital Management LP | 0 | $0 | 0.00% | −12,137−100.0% | Sold out |
| SkyView Investment Advisors, LLC | 0 | $0 | 0.00% | −3,000−100.0% | Sold out |
| Northern Trust Corp | 0 | $0 | 0.00% | −2,422−100.0% | Sold out |
| BNP Paribas Arbitrage, SA | 0 | $0 | 0.00% | −2,000−100.0% | Sold out |
| Bank of America Corp | 0 | $0 | 0.00% | −93−100.0% | Sold out |
| Royal Bank of Canada | 0 | $0 | 0.00% | −40−100.0% | Sold out |
| Vanguard Group Inc | – | – | – | – | Not filed |