Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Spruce Biosciences, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 32
- +1 vs. Q4 2025
- Shares held
- 739.8K
- +3.78K (+0.5%) vs. Q4 2025
- Total value
- $48.3M
- −$15.7M (−24.5%) vs. Q4 2025
- New holders
- 10
- 6 more added
- Sold out
- 9
- 6 more reduced
1 institution that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Cassaday & Co Wealth Management LLC | 2 | $130 | 0.00% | +2 | New |
| Caldwell Sutter Capital, Inc. | 13 | $850 | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 140 | $9.15K | 0.00% | +139+13,900.0% | Added |
| Jones Financial Companies LLLP | 193 | $12.2K | 0.00% | +109+129.8% | Added |
| Sound Income Strategies, LLC | 200 | $13.9K | 0.00% | 00.0% | Unchanged |
| Vanguard Global Advisers, LLC | 452 | $29.5K | 0.00% | +452 | New |
| Citigroup Inc | 939 | $61.4K | 0.00% | +939 | New |
| Lion Point Capital, LP | 1,000 | $65.3K | 0.39% | 00.0% | Unchanged |
| Morgan Stanley | 1,415 | $92.5K | 0.00% | +1,027+264.7% | Added |
| Persistent Asset Partners Ltd | 2,528 | $165.2K | 0.06% | +2,528 | New |
| UBS Group AG | 3,919 | $256.1K | 0.00% | −983−20.1% | Reduced |
| Resolute Capital Asset Partners LLC | 4,000 | $261.4K | 0.14% | 00.0% | Unchanged |
| State Street Corp | 5,400 | $352.9K | 0.00% | −1,000−15.6% | Reduced |
| Goldman Sachs Group Inc | 5,506 | $359.8K | 0.00% | +5,506 | New |
| Vanguard Fiduciary Trust Co | 5,514 | $360.3K | 0.00% | +5,514 | New |
| StemPoint Capital LP | 6,360 | $415.6K | 0.08% | +6,360 | New |
| Diadema Partners LP | 10,000 | $653.5K | 0.27% | +10,000 | New |
| Squadron Capital Management LLC | 12,200 | $797.3K | 0.32% | −57,800−82.6% | Reduced |
| Geode Capital Management, LLC | 12,889 | $842.7K | 0.00% | +157+1.2% | Added |
| BlackRock, Inc. | 16,938 | $1.11M | 0.00% | 00.0% | Unchanged |
| Vanguard Capital Management LLC | 18,337 | $1.20M | 0.00% | +18,337 | New |
| ExodusPoint Capital Management, LP | 22,000 | $1.44M | 0.01% | −3,271−12.9% | Reduced |
| Quinn Opportunity Partners LLC | 26,810 | $1.75M | 0.09% | +4,000+17.5% | Added |
| Carlyle Group Inc. | 38,620 | $2.52M | 0.02% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 40,000 | $2.61M | 0.01% | 00.0% | Unchanged |
| Boothbay Fund Management, LLC | 42,080 | $2.75M | 0.06% | −5,853−12.2% | Reduced |
| Wellington Management Group LLP | 48,796 | $3.19M | 0.00% | −10,153−17.2% | Reduced |
| Alyeska Investment Group, L.P. | 51,671 | $3.38M | 0.01% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 58,600 | $3.83M | 0.23% | +600+1.0% | Added |
| Citadel Advisors LLC | 69,999 | $4.57M | 0.00% | 00.0% | Unchanged |
| Millennium Management LLC | 111,888 | $7.31M | 0.01% | +111,888 | New |
| Ikarian Capital, LLC | 121,356 | $7.93M | 1.13% | 00.0% | Unchanged |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −24,767−100.0% | Sold out |
| Caligan Partners LP | 0 | $0 | 0.00% | −20,514−100.0% | Sold out |
| Stonepine Capital Management, LLC | 0 | $0 | 0.00% | −19,742−100.0% | Sold out |
| Superstring Capital Management LP | 0 | $0 | 0.00% | −12,137−100.0% | Sold out |
| SkyView Investment Advisors, LLC | 0 | $0 | 0.00% | −3,000−100.0% | Sold out |
| Northern Trust Corp | 0 | $0 | 0.00% | −2,422−100.0% | Sold out |
| BNP Paribas Arbitrage, SA | 0 | $0 | 0.00% | −2,000−100.0% | Sold out |
| Bank of America Corp | 0 | $0 | 0.00% | −93−100.0% | Sold out |
| Royal Bank of Canada | 0 | $0 | 0.00% | −40−100.0% | Sold out |
| Vanguard Group Inc | – | – | – | – | Not filed |