Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q1 2023
Institutional positions in Spruce Biosciences, Inc. as of Mar 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 44
- +14 vs. Q4 2022
- Shares held
- 33.8M
- +17.3M (+105.2%) vs. Q4 2022
- Total value
- $74.5M
- +$56.5M (+313.6%) vs. Q4 2022
- New holders
- 16
- 11 more added
- Sold out
- 2
- 10 more reduced
1 institution that held it in Q4 2022 haven't filed for Q1 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q1 2023
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q4 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Novo Holdings A/S | 6,722,336 | $14.9M | 1.06% | +2,208,000+48.9% | Added |
| Armistice Capital, LLC | 3,928,000 | $8.68M | 0.20% | +3,928,000 | New |
| RiverVest Venture Management LLC | 2,936,281 | $6.49M | 7.51% | +788,000+36.7% | Added |
| Carlyle Group Inc. | 2,896,518 | $6.40M | 0.19% | +2,896,518 | New |
| Rock Springs Capital Management LP | 2,728,125 | $6.03M | 0.14% | +1,105,436+68.1% | Added |
| 5AM Venture Management, LLC | 2,364,000 | $5.22M | 1.34% | +2,364,000 | New |
| Omega Fund Management, LLC | 2,161,022 | $4.78M | 3.11% | 00.0% | Unchanged |
| Citadel Advisors LLC | 1,698,618 | $3.75M | 0.00% | −48,773−2.8% | Reduced |
| Aisling Capital Management LP | 1,205,511 | $2.66M | 1.28% | 00.0% | Unchanged |
| AIGH Capital Management LLC | 1,104,000 | $2.37M | 0.88% | +1,104,000 | New |
| Alyeska Investment Group, L.P. | 1,000,000 | $2.21M | 0.02% | +1,000,000 | New |
| Verition Fund Management LLC | 961,899 | $2.13M | 0.03% | +961,899 | New |
| Sands Capital Ventures, LLC | 787,007 | $1.74M | 0.43% | 00.0% | Unchanged |
| Millennium Management LLC | 608,845 | $1.35M | 0.00% | +461,349+312.8% | Added |
| CVI Holdings, LLC | 472,000 | $1.04M | 0.39% | +472,000 | New |
| DAFNA Capital Management LLC | 312,000 | $689.5K | 0.21% | +312,000 | New |
| Worth Venture Partners, LLC | 270,624 | $581.5K | 0.29% | +270,624 | New |
| Vanguard Group Inc | 246,578 | $544.9K | 0.00% | +121,465+97.1% | Added |
| Goldman Sachs Group Inc | 182,656 | $403.7K | 0.00% | +182,656 | New |
| Two Sigma Investments, LP | 163,165 | $360.6K | 0.00% | +163,165 | New |
| Renaissance Technologies LLC | 160,100 | $354.0K | 0.00% | +21,683+15.7% | Added |
| BlackRock Inc. | 151,313 | $334.4K | 0.00% | +894+0.6% | Added |
| Royal Bank of Canada | 93,920 | $208.0K | 0.00% | +93,920 | New |
| State Street Corp | 93,100 | $205.8K | 0.00% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 92,077 | $203.5K | 0.00% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 85,000 | $187.8K | 0.00% | +25,000+41.7% | Added |
| Geode Capital Management, LLC | 60,621 | $134.0K | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 58,179 | $129.0K | 0.00% | +58,168+528,800.0% | Added |
| Marquette Asset Management, LLC | 55,757 | $123.2K | 0.03% | −12,600−18.4% | Reduced |
| Dimensional Fund Advisors LP | 39,168 | $86.6K | 0.00% | +28,907+281.7% | Added |
| Two Sigma Advisers, LP | 37,600 | $83.1K | 0.00% | +37,600 | New |
| Privium Fund Management (UK) Ltd | 24,554 | $52.5K | 0.04% | −25,846−51.3% | Reduced |
| Northern Trust Corp | 13,741 | $30.4K | 0.00% | −326−2.3% | Reduced |
| Virtu Financial LLC | 13,722 | $30.0K | 0.00% | +13,722 | New |
| HRT Financial LP | 13,340 | $29.0K | 0.00% | +13,340 | New |
| Barclays PLC | 7,484 | $16.5K | 0.00% | −152−2.0% | Reduced |
| Tower Research Capital LLC (TRC) | 3,880 | $9.00K | 0.00% | −7,046−64.5% | Reduced |
| Morgan Stanley | 3,150 | $6.96K | 0.00% | −189−5.7% | Reduced |
| Federated Hermes, Inc. | 1,032 | $2.28K | 0.00% | −174−14.4% | Reduced |
| UBS Group AG | 960 | $2.12K | 0.00% | −4,684−83.0% | Reduced |
| TCI Wealth Advisors, Inc. | 250 | $553 | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 249 | $550 | 0.00% | +238+2,163.6% | Added |
| Wells Fargo & Company | 67 | $148 | 0.00% | −399−85.6% | Reduced |
| FMR LLC | 50 | $111 | 0.00% | +50 | New |
| Logos Global Management LP | 0 | $0 | 0.00% | −1,000,000−100.0% | Sold out |
| BML Capital Management, LLC | 0 | $0 | 0.00% | −221,830−100.0% | Sold out |
| Abingworth LLP | – | – | – | – | Not filed |