Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q1 2023
Institutional positions in Spruce Biosciences, Inc. as of Mar 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 44
- +14 vs. Q4 2022
- Shares held
- 33.8M
- +17.3M (+105.2%) vs. Q4 2022
- Total value
- $74.5M
- +$56.5M (+313.6%) vs. Q4 2022
- New holders
- 16
- 11 more added
- Sold out
- 2
- 10 more reduced
1 institution that held it in Q4 2022 haven't filed for Q1 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q1 2023
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q4 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 50 | $111 | 0.00% | +50 | New |
| Wells Fargo & Company | 67 | $148 | 0.00% | −399−85.6% | Reduced |
| Bank of America Corp | 249 | $550 | 0.00% | +238+2,163.6% | Added |
| TCI Wealth Advisors, Inc. | 250 | $553 | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 960 | $2.12K | 0.00% | −4,684−83.0% | Reduced |
| Federated Hermes, Inc. | 1,032 | $2.28K | 0.00% | −174−14.4% | Reduced |
| Morgan Stanley | 3,150 | $6.96K | 0.00% | −189−5.7% | Reduced |
| Tower Research Capital LLC (TRC) | 3,880 | $9.00K | 0.00% | −7,046−64.5% | Reduced |
| Barclays PLC | 7,484 | $16.5K | 0.00% | −152−2.0% | Reduced |
| HRT Financial LP | 13,340 | $29.0K | 0.00% | +13,340 | New |
| Virtu Financial LLC | 13,722 | $30.0K | 0.00% | +13,722 | New |
| Northern Trust Corp | 13,741 | $30.4K | 0.00% | −326−2.3% | Reduced |
| Privium Fund Management (UK) Ltd | 24,554 | $52.5K | 0.04% | −25,846−51.3% | Reduced |
| Two Sigma Advisers, LP | 37,600 | $83.1K | 0.00% | +37,600 | New |
| Dimensional Fund Advisors LP | 39,168 | $86.6K | 0.00% | +28,907+281.7% | Added |
| Marquette Asset Management, LLC | 55,757 | $123.2K | 0.03% | −12,600−18.4% | Reduced |
| JPMorgan Chase & Co | 58,179 | $129.0K | 0.00% | +58,168+528,800.0% | Added |
| Geode Capital Management, LLC | 60,621 | $134.0K | 0.00% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 85,000 | $187.8K | 0.00% | +25,000+41.7% | Added |
| Bank of New York Mellon Corp | 92,077 | $203.5K | 0.00% | 00.0% | Unchanged |
| State Street Corp | 93,100 | $205.8K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 93,920 | $208.0K | 0.00% | +93,920 | New |
| BlackRock Inc. | 151,313 | $334.4K | 0.00% | +894+0.6% | Added |
| Renaissance Technologies LLC | 160,100 | $354.0K | 0.00% | +21,683+15.7% | Added |
| Two Sigma Investments, LP | 163,165 | $360.6K | 0.00% | +163,165 | New |
| Goldman Sachs Group Inc | 182,656 | $403.7K | 0.00% | +182,656 | New |
| Vanguard Group Inc | 246,578 | $544.9K | 0.00% | +121,465+97.1% | Added |
| Worth Venture Partners, LLC | 270,624 | $581.5K | 0.29% | +270,624 | New |
| DAFNA Capital Management LLC | 312,000 | $689.5K | 0.21% | +312,000 | New |
| CVI Holdings, LLC | 472,000 | $1.04M | 0.39% | +472,000 | New |
| Millennium Management LLC | 608,845 | $1.35M | 0.00% | +461,349+312.8% | Added |
| Sands Capital Ventures, LLC | 787,007 | $1.74M | 0.43% | 00.0% | Unchanged |
| Verition Fund Management LLC | 961,899 | $2.13M | 0.03% | +961,899 | New |
| Alyeska Investment Group, L.P. | 1,000,000 | $2.21M | 0.02% | +1,000,000 | New |
| AIGH Capital Management LLC | 1,104,000 | $2.37M | 0.88% | +1,104,000 | New |
| Aisling Capital Management LP | 1,205,511 | $2.66M | 1.28% | 00.0% | Unchanged |
| Citadel Advisors LLC | 1,698,618 | $3.75M | 0.00% | −48,773−2.8% | Reduced |
| Omega Fund Management, LLC | 2,161,022 | $4.78M | 3.11% | 00.0% | Unchanged |
| 5AM Venture Management, LLC | 2,364,000 | $5.22M | 1.34% | +2,364,000 | New |
| Rock Springs Capital Management LP | 2,728,125 | $6.03M | 0.14% | +1,105,436+68.1% | Added |
| Carlyle Group Inc. | 2,896,518 | $6.40M | 0.19% | +2,896,518 | New |
| RiverVest Venture Management LLC | 2,936,281 | $6.49M | 7.51% | +788,000+36.7% | Added |
| Armistice Capital, LLC | 3,928,000 | $8.68M | 0.20% | +3,928,000 | New |
| Novo Holdings A/S | 6,722,336 | $14.9M | 1.06% | +2,208,000+48.9% | Added |
| Logos Global Management LP | 0 | $0 | 0.00% | −1,000,000−100.0% | Sold out |
| BML Capital Management, LLC | 0 | $0 | 0.00% | −221,830−100.0% | Sold out |
| Abingworth LLP | – | – | – | – | Not filed |