Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q3 2021
Institutional positions in Spruce Biosciences, Inc. as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 44
- +3 vs. Q2 2021
- Shares held
- 19.6M
- −456.3K (−2.3%) vs. Q2 2021
- Total value
- $118.1M
- −$107.2M (−47.6%) vs. Q2 2021
- New holders
- 7
- 15 more added
- Sold out
- 4
- 16 more reduced
Compare with Q2 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q3 2021
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q2 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Novo Holdings A/S | 4,514,336 | $27.1M | 1.40% | 00.0% | Unchanged |
| Deerfield Management Company, L.P. (Series C) | 2,200,000 | $13.2M | 0.26% | +153,042+7.5% | Added |
| Omega Fund Management, LLC | 2,161,022 | $13.0M | 1.46% | 00.0% | Unchanged |
| RiverVest Venture Management LLC | 2,148,281 | $12.9M | 2.17% | 00.0% | Unchanged |
| Citadel Advisors LLC | 1,701,076 | $10.2M | 0.01% | −1,938−0.1% | Reduced |
| Rock Springs Capital Management LP | 1,617,601 | $9.72M | 0.20% | +12,600+0.8% | Added |
| Aisling Capital Management LP | 1,205,511 | $7.25M | 1.44% | 00.0% | Unchanged |
| FMR LLC | 951,529 | $5.72M | 0.00% | −234,144−19.7% | Reduced |
| Sands Capital Ventures, LLC | 787,007 | $4.73M | 0.71% | +787,007 | New |
| Sio Capital Management, LLC | 603,027 | $3.62M | 1.17% | −44,212−6.8% | Reduced |
| BlackRock Inc. | 421,257 | $2.53M | 0.00% | +1,468+0.3% | Added |
| Vanguard Group Inc | 370,850 | $2.23M | 0.00% | +1,330+0.4% | Added |
| State Street Corp | 127,817 | $768.0K | 0.00% | +2,899+2.3% | Added |
| JPMorgan Chase & Co | 125,459 | $754.0K | 0.00% | −38,398−23.4% | Reduced |
| Geode Capital Management, LLC | 111,417 | $669.0K | 0.00% | −17,129−13.3% | Reduced |
| Morgan Stanley | 75,911 | $456.0K | 0.00% | −46,679−38.1% | Reduced |
| Northern Trust Corp | 74,670 | $449.0K | 0.00% | −3,194−4.1% | Reduced |
| Granite Point Capital Management, L.P. | 63,614 | $382.0K | 0.15% | −36,386−36.4% | Reduced |
| Millennium Management LLC | 38,622 | $232.0K | 0.00% | +21,406+124.3% | Added |
| Renaissance Technologies LLC | 34,000 | $204.0K | 0.00% | +34,000 | New |
| Two Sigma Investments, LP | 29,392 | $177.0K | 0.00% | +17,417+145.4% | Added |
| Alps Advisors Inc | 28,648 | $172.0K | 0.00% | −2,078−6.8% | Reduced |
| Caas Capital Management LP | 27,546 | $166.0K | 0.01% | −64,866−70.2% | Reduced |
| Bank of New York Mellon Corp | 27,448 | $165.0K | 0.00% | +1,882+7.4% | Added |
| Nuveen Asset Management, LLC | 23,018 | $164.0K | 0.00% | −6,598−22.3% | Reduced |
| Jacobs Levy Equity Management, Inc | 24,361 | $146.0K | 0.00% | +24,361 | New |
| Two Sigma Advisers, LP | 19,200 | $115.0K | 0.00% | +19,200 | New |
| Charles Schwab Investment Management Inc | 18,417 | $111.0K | 0.00% | −24,812−57.4% | Reduced |
| State Board of Administration of Florida Retirement System | 17,440 | $105.0K | 0.00% | +17,440 | New |
| Bank of America Corp | 16,818 | $102.0K | 0.00% | +8,965+114.2% | Added |
| Goldman Sachs Group Inc | 12,956 | $78.0K | 0.00% | +2,186+20.3% | Added |
| Trexquant Investment LP | 11,998 | $72.0K | 0.01% | +11,998 | New |
| Laurion Capital Management LP | 11,337 | $68.0K | 0.00% | −3,620−24.2% | Reduced |
| Wells Fargo & Company | 10,919 | $66.0K | 0.00% | +3,885+55.2% | Added |
| New York State Common Retirement Fund | 6,091 | $37.0K | 0.00% | +32+0.5% | Added |
| Deutsche Bank AG | 4,998 | $30.0K | 0.00% | −187−3.6% | Reduced |
| American International Group, Inc. | 4,753 | $29.0K | 0.00% | −113−2.3% | Reduced |
| California State Teachers Retirement System | 4,640 | $28.0K | 0.00% | −7,366−61.4% | Reduced |
| Tower Research Capital LLC (TRC) | 3,261 | $20.0K | 0.00% | +2,328+249.5% | Added |
| Citigroup Inc | 1,380 | $8.00K | 0.00% | +966+233.3% | Added |
| Legal & General Group Plc | 782 | $5.00K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 906 | $5.00K | 0.00% | +311+52.3% | Added |
| Ameritas Investment Partners, Inc. | 584 | $4.00K | 0.00% | 00.0% | Unchanged |
| Ellevest, Inc. | 31 | $0 | 0.00% | +31 | New |
| Sands Capital Management, LLC | 0 | $0 | 0.00% | −787,007−100.0% | Sold out |
| Adage Capital Partners GP, L.L.C. | 0 | $0 | 0.00% | −240,511−100.0% | Sold out |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −19,413−100.0% | Sold out |
| STRS Ohio | 0 | $0 | 0.00% | −2,400−100.0% | Sold out |