Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q3 2021
Institutional positions in Spruce Biosciences, Inc. as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 44
- +3 vs. Q2 2021
- Shares held
- 19.6M
- −456.3K (−2.3%) vs. Q2 2021
- Total value
- $118.1M
- −$107.2M (−47.6%) vs. Q2 2021
- New holders
- 7
- 15 more added
- Sold out
- 4
- 16 more reduced
Compare with Q2 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q3 2021
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q2 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ellevest, Inc. | 31 | $0 | 0.00% | +31 | New |
| Ameritas Investment Partners, Inc. | 584 | $4.00K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 782 | $5.00K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 906 | $5.00K | 0.00% | +311+52.3% | Added |
| Citigroup Inc | 1,380 | $8.00K | 0.00% | +966+233.3% | Added |
| Tower Research Capital LLC (TRC) | 3,261 | $20.0K | 0.00% | +2,328+249.5% | Added |
| California State Teachers Retirement System | 4,640 | $28.0K | 0.00% | −7,366−61.4% | Reduced |
| American International Group, Inc. | 4,753 | $29.0K | 0.00% | −113−2.3% | Reduced |
| Deutsche Bank AG | 4,998 | $30.0K | 0.00% | −187−3.6% | Reduced |
| New York State Common Retirement Fund | 6,091 | $37.0K | 0.00% | +32+0.5% | Added |
| Wells Fargo & Company | 10,919 | $66.0K | 0.00% | +3,885+55.2% | Added |
| Laurion Capital Management LP | 11,337 | $68.0K | 0.00% | −3,620−24.2% | Reduced |
| Trexquant Investment LP | 11,998 | $72.0K | 0.01% | +11,998 | New |
| Goldman Sachs Group Inc | 12,956 | $78.0K | 0.00% | +2,186+20.3% | Added |
| Bank of America Corp | 16,818 | $102.0K | 0.00% | +8,965+114.2% | Added |
| State Board of Administration of Florida Retirement System | 17,440 | $105.0K | 0.00% | +17,440 | New |
| Charles Schwab Investment Management Inc | 18,417 | $111.0K | 0.00% | −24,812−57.4% | Reduced |
| Two Sigma Advisers, LP | 19,200 | $115.0K | 0.00% | +19,200 | New |
| Jacobs Levy Equity Management, Inc | 24,361 | $146.0K | 0.00% | +24,361 | New |
| Nuveen Asset Management, LLC | 23,018 | $164.0K | 0.00% | −6,598−22.3% | Reduced |
| Bank of New York Mellon Corp | 27,448 | $165.0K | 0.00% | +1,882+7.4% | Added |
| Caas Capital Management LP | 27,546 | $166.0K | 0.01% | −64,866−70.2% | Reduced |
| Alps Advisors Inc | 28,648 | $172.0K | 0.00% | −2,078−6.8% | Reduced |
| Two Sigma Investments, LP | 29,392 | $177.0K | 0.00% | +17,417+145.4% | Added |
| Renaissance Technologies LLC | 34,000 | $204.0K | 0.00% | +34,000 | New |
| Millennium Management LLC | 38,622 | $232.0K | 0.00% | +21,406+124.3% | Added |
| Granite Point Capital Management, L.P. | 63,614 | $382.0K | 0.15% | −36,386−36.4% | Reduced |
| Northern Trust Corp | 74,670 | $449.0K | 0.00% | −3,194−4.1% | Reduced |
| Morgan Stanley | 75,911 | $456.0K | 0.00% | −46,679−38.1% | Reduced |
| Geode Capital Management, LLC | 111,417 | $669.0K | 0.00% | −17,129−13.3% | Reduced |
| JPMorgan Chase & Co | 125,459 | $754.0K | 0.00% | −38,398−23.4% | Reduced |
| State Street Corp | 127,817 | $768.0K | 0.00% | +2,899+2.3% | Added |
| Vanguard Group Inc | 370,850 | $2.23M | 0.00% | +1,330+0.4% | Added |
| BlackRock Inc. | 421,257 | $2.53M | 0.00% | +1,468+0.3% | Added |
| Sio Capital Management, LLC | 603,027 | $3.62M | 1.17% | −44,212−6.8% | Reduced |
| Sands Capital Ventures, LLC | 787,007 | $4.73M | 0.71% | +787,007 | New |
| FMR LLC | 951,529 | $5.72M | 0.00% | −234,144−19.7% | Reduced |
| Aisling Capital Management LP | 1,205,511 | $7.25M | 1.44% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 1,617,601 | $9.72M | 0.20% | +12,600+0.8% | Added |
| Citadel Advisors LLC | 1,701,076 | $10.2M | 0.01% | −1,938−0.1% | Reduced |
| RiverVest Venture Management LLC | 2,148,281 | $12.9M | 2.17% | 00.0% | Unchanged |
| Omega Fund Management, LLC | 2,161,022 | $13.0M | 1.46% | 00.0% | Unchanged |
| Deerfield Management Company, L.P. (Series C) | 2,200,000 | $13.2M | 0.26% | +153,042+7.5% | Added |
| Novo Holdings A/S | 4,514,336 | $27.1M | 1.40% | 00.0% | Unchanged |
| Sands Capital Management, LLC | 0 | $0 | 0.00% | −787,007−100.0% | Sold out |
| Adage Capital Partners GP, L.L.C. | 0 | $0 | 0.00% | −240,511−100.0% | Sold out |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −19,413−100.0% | Sold out |
| STRS Ohio | 0 | $0 | 0.00% | −2,400−100.0% | Sold out |