Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q4 2021
Institutional positions in Spruce Biosciences, Inc. as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 50
- +6 vs. Q3 2021
- Shares held
- 17.7M
- −1.93M (−9.8%) vs. Q3 2021
- Total value
- $79.0M
- −$39.1M (−33.1%) vs. Q3 2021
- New holders
- 16
- 14 more added
- Sold out
- 10
- 9 more reduced
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Novo Holdings A/S | 4,514,336 | $20.1M | 0.95% | 00.0% | Unchanged |
| Omega Fund Management, LLC | 2,161,022 | $9.64M | 1.36% | 00.0% | Unchanged |
| RiverVest Venture Management LLC | 2,148,281 | $9.58M | 6.84% | 00.0% | Unchanged |
| Citadel Advisors LLC | 1,727,101 | $7.70M | 0.01% | +26,025+1.5% | Added |
| Rock Springs Capital Management LP | 1,622,689 | $7.24M | 0.17% | +5,088+0.3% | Added |
| Aisling Capital Management LP | 1,205,511 | $5.38M | 1.90% | 00.0% | Unchanged |
| Logos Global Management LP | 1,100,000 | $4.91M | 0.51% | +1,100,000 | New |
| Sands Capital Ventures, LLC | 787,007 | $3.51M | 0.52% | 00.0% | Unchanged |
| BlackRock Inc. | 420,328 | $1.88M | 0.00% | −929−0.2% | Reduced |
| Vanguard Group Inc | 372,127 | $1.66M | 0.00% | +1,277+0.3% | Added |
| Goldman Sachs Group Inc | 230,801 | $1.03M | 0.00% | +217,845+1,681.4% | Added |
| Bridgeway Capital Management, LLC | 209,864 | $936.0K | 0.02% | +209,864 | New |
| Geode Capital Management, LLC | 142,469 | $635.0K | 0.00% | +31,052+27.9% | Added |
| State Street Corp | 126,969 | $566.0K | 0.00% | −848−0.7% | Reduced |
| JPMorgan Chase & Co | 118,367 | $528.0K | 0.00% | −7,092−5.7% | Reduced |
| FMR LLC | 114,500 | $511.0K | 0.00% | −837,029−88.0% | Reduced |
| Bank of America Corp | 83,104 | $371.0K | 0.00% | +66,286+394.1% | Added |
| Northern Trust Corp | 75,011 | $334.0K | 0.00% | +341+0.5% | Added |
| Acadian Asset Management LLC | 71,756 | $318.0K | 0.00% | +71,756 | New |
| Parametric Portfolio Associates LLC | 64,628 | $288.0K | 0.00% | +64,628 | New |
| Marquette Asset Management, LLC | 40,853 | $182.0K | 0.04% | +40,853 | New |
| Cubist Systematic Strategies, LLC | 40,589 | $181.0K | 0.00% | +40,589 | New |
| Renaissance Technologies LLC | 39,800 | $178.0K | 0.00% | +5,800+17.1% | Added |
| Jane Street Group, LLC | 35,953 | $160.0K | 0.00% | +35,953 | New |
| Bank of Montreal | 26,259 | $132.0K | 0.00% | +26,259 | New |
| Two Sigma Securities, LLC | 28,691 | $128.0K | 0.02% | +28,691 | New |
| Bank of New York Mellon Corp | 27,893 | $124.0K | 0.00% | +445+1.6% | Added |
| Susquehanna International Group, LLP | 27,306 | $122.0K | 0.00% | +27,306 | New |
| Charles Schwab Investment Management Inc | 18,417 | $83.0K | 0.00% | 00.0% | Unchanged |
| State Board of Administration of Florida Retirement System | 17,440 | $78.0K | 0.00% | 00.0% | Unchanged |
| Prelude Capital Management, LLC | 16,718 | $75.0K | 0.00% | +16,718 | New |
| Squarepoint Ops LLC | 13,593 | $61.0K | 0.00% | +13,593 | New |
| Morgan Stanley | 12,391 | $55.0K | 0.00% | −63,520−83.7% | Reduced |
| Laurion Capital Management LP | 11,337 | $51.0K | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 9,475 | $43.0K | 0.00% | −1,444−13.2% | Reduced |
| Nuveen Asset Management, LLC | 11,643 | $29.0K | 0.00% | −11,375−49.4% | Reduced |
| New York State Common Retirement Fund | 6,091 | $27.0K | 0.00% | 00.0% | Unchanged |
| Deutsche Bank AG | 5,278 | $24.0K | 0.00% | +280+5.6% | Added |
| UBS Group AG | 5,349 | $24.0K | 0.00% | +5,349 | New |
| Tower Research Capital LLC (TRC) | 4,948 | $22.0K | 0.00% | +1,687+51.7% | Added |
| American International Group, Inc. | 4,615 | $21.0K | 0.00% | −138−2.9% | Reduced |
| California State Teachers Retirement System | 3,712 | $17.0K | 0.00% | −928−20.0% | Reduced |
| Citigroup Inc | 2,207 | $10.0K | 0.00% | +827+59.9% | Added |
| Royal Bank of Canada | 1,776 | $8.00K | 0.00% | +870+96.0% | Added |
| Captrust Financial Advisors | 1,477 | $7.00K | 0.00% | +1,477 | New |
| Legal & General Group Plc | 782 | $3.00K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 584 | $3.00K | 0.00% | 00.0% | Unchanged |
| Ellevest, Inc. | 114 | $1.00K | 0.00% | +83+267.7% | Added |
| TCI Wealth Advisors, Inc. | 250 | $1.00K | 0.00% | +250 | New |
| Capital Advisors, Ltd. LLC | 242 | $1.00K | 0.00% | +242 | New |
| Deerfield Management Company, L.P. (Series C) | 0 | $0 | 0.00% | −2,200,000−100.0% | Sold out |
| Sio Capital Management, LLC | 0 | $0 | 0.00% | −603,027−100.0% | Sold out |
| Granite Point Capital Management, L.P. | 0 | $0 | 0.00% | −63,614−100.0% | Sold out |
| Millennium Management LLC | 0 | $0 | 0.00% | −38,622−100.0% | Sold out |
| Two Sigma Investments, LP | 0 | $0 | 0.00% | −29,392−100.0% | Sold out |
| Alps Advisors Inc | 0 | $0 | 0.00% | −28,648−100.0% | Sold out |
| Caas Capital Management LP | 0 | $0 | 0.00% | −27,546−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −24,361−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −19,200−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −11,998−100.0% | Sold out |