Spruce Biosciences, Inc.

SPRB

Exchange: Nasdaq
Industry: Pharmaceutical Preparations
SEC CIK: 0001683553

SEC filings (opens in a new tab)

No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.

Q4 2025 vs. Q3 2025

How the institutions holding Spruce Biosciences, Inc. changed between Q3 2025 and Q4 2025.

All holders in Q4 2025 All holders in Q3 2025

13F holders of SPRB: Q3 2025 compared with Q4 2025
Measure	Q3 2025	Q4 2025	Change
Holders	9	32	+23
Shares	2.94M	753.9K	−2.18M (−74.3%)
Value	$25.1M	$65.6M	+$40.5M (+161.0%)

New holders (25)

Institutions that held Spruce Biosciences, Inc. at the end of Q4 2025 but not at the end of Q3 2025.

Institutions new to SPRB in Q4 2025
Institution	Shares	Value	% of portfolio
Squadron Capital Management LLC	70,000	$6.10M	2.72%
Citadel Advisors LLC	69,999	$6.10M	0.00%
Wellington Management Group LLP	58,949	$5.14M	0.00%
ADAR1 Capital Management, LLC	58,000	$5.05M	0.38%
Alyeska Investment Group, L.P.	51,671	$4.50M	0.01%
Boothbay Fund Management, LLC	47,933	$4.18M	0.11%
Balyasny Asset Management LLC	40,000	$3.48M	0.01%
ExodusPoint Capital Management, LP	25,271	$2.20M	0.02%
Schonfeld Strategic Advisors LLC	24,767	$2.16M	0.01%
Quinn Opportunity Partners LLC	22,810	$1.99M	0.09%
Caligan Partners LP	20,514	$1.79M	0.16%
Stonepine Capital Management, LLC	19,742	$1.72M	1.36%
Vanguard Group Inc	17,873	$1.56M	0.00%
BlackRock, Inc.	16,938	$1.48M	0.00%
Geode Capital Management, LLC	12,732	$1.11M	0.00%
Superstring Capital Management LP	12,137	$1.06M	0.57%
State Street Corp	6,400	$557.5K	0.00%
Resolute Capital Asset Partners LLC	4,000	$348.4K	0.17%
SkyView Investment Advisors, LLC	3,000	$261.0K	0.03%
Northern Trust Corp	2,422	$211.0K	0.00%
BNP Paribas Arbitrage, SA	2,000	$174.2K	0.00%
Sound Income Strategies, LLC	200	$14.7K	0.00%
Jones Financial Companies LLLP	84	$7.32K	0.00%
Royal Bank of Canada	40	$3.00K	0.00%
Tower Research Capital LLC (TRC)	1	$87	0.00%

Sold out (2)

Institutions that held Spruce Biosciences, Inc. at the end of Q3 2025 and filed for Q4 2025 without it.

Institutions that sold out of SPRB in Q4 2025
Institution	Shares, Q3 2025	Value, Q3 2025
Cable Car Capital LLC	26,666	$238.7K
Advisor Group Holdings, Inc.	133	$931