Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q4 2023
Institutional positions in Spruce Biosciences, Inc. as of Dec 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 40
- −1 vs. Q3 2023
- Shares held
- 32.3M
- +369.4K (+1.2%) vs. Q3 2023
- Total value
- $94.4M
- +$22.4M (+31.1%) vs. Q3 2023
- New holders
- 4
- 10 more added
- Sold out
- 5
- 11 more reduced
Compare with Q3 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q4 2023
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q3 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Qube Research & Technologies Ltd | 2 | $6 | 0.00% | +2 | New |
| JPMorgan Chase & Co | 11 | $32 | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 13 | $38 | 0.00% | −297−95.8% | Reduced |
| Wells Fargo & Company | 141 | $413 | 0.00% | +11+8.5% | Added |
| UBS Group AG | 485 | $1.42K | 0.00% | +472+3,630.8% | Added |
| Caldwell Sutter Capital, Inc. | 1,000 | $2.93K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 2,133 | $6.25K | 0.00% | +2+0.1% | Added |
| Royal Bank of Canada | 8,907 | $26.0K | 0.00% | −744−7.7% | Reduced |
| Charles Schwab Investment Management Inc | 15,289 | $44.8K | 0.00% | 00.0% | Unchanged |
| Sofinnova Investments, Inc. | 22,767 | $66.7K | 0.00% | −35,262−60.8% | Reduced |
| Privium Fund Management (UK) Ltd | 24,554 | $71.9K | 0.05% | 00.0% | Unchanged |
| Marquette Asset Management, LLC | 55,757 | $163.4K | 0.03% | 00.0% | Unchanged |
| State Street Corp | 61,993 | $181.6K | 0.00% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 85,000 | $249.1K | 0.01% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 95,600 | $280.1K | 0.00% | −700−0.7% | Reduced |
| Northern Trust Corp | 96,688 | $283.3K | 0.00% | +48,024+98.7% | Added |
| Marshall Wace, LLP | 105,721 | $309.8K | 0.00% | +105,721 | New |
| Citadel Advisors LLC | 108,240 | $317.1K | 0.00% | +33,210+44.3% | Added |
| Superstring Capital Management LP | 118,814 | $348.1K | 0.25% | +118,814 | New |
| Two Sigma Investments, LP | 134,357 | $393.7K | 0.00% | −13,000−8.8% | Reduced |
| Geode Capital Management, LLC | 167,404 | $490.6K | 0.00% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 185,100 | $542.0K | 0.00% | −22,676−10.9% | Reduced |
| BlackRock Inc. | 261,016 | $764.8K | 0.00% | +2,515+1.0% | Added |
| Acuitas Investments, LLC | 275,085 | $806.0K | 0.42% | +840.0% | Added |
| Alyeska Investment Group, L.P. | 400,000 | $1.17M | 0.01% | −600,000−60.0% | Reduced |
| Millennium Management LLC | 510,441 | $1.50M | 0.00% | −73,031−12.5% | Reduced |
| Worth Venture Partners, LLC | 526,933 | $1.54M | 0.84% | +224,859+74.4% | Added |
| DAFNA Capital Management LLC | 548,510 | $1.61M | 0.39% | −21,620−3.8% | Reduced |
| Sands Capital Ventures, LLC | 787,007 | $2.31M | 0.64% | 00.0% | Unchanged |
| Vanguard Group Inc | 822,390 | $2.41M | 0.00% | +494,121+150.5% | Added |
| Aisling Capital Management LP | 1,205,511 | $3.53M | 1.05% | 00.0% | Unchanged |
| Rosalind Advisors, Inc. | 1,586,392 | $4.65M | 3.89% | +1,586,392 | New |
| AIGH Capital Management LLC | 2,123,863 | $6.22M | 2.46% | +912,863+75.4% | Added |
| Omega Fund Management, LLC | 2,161,022 | $6.33M | 5.13% | 00.0% | Unchanged |
| Armistice Capital, LLC | 2,230,000 | $6.53M | 0.17% | −826,000−27.0% | Reduced |
| 5AM Venture Management, LLC | 2,364,000 | $6.93M | 1.84% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 2,609,125 | $7.64M | 0.19% | −119,000−4.4% | Reduced |
| Carlyle Group Inc. | 2,896,518 | $8.37M | 0.40% | 00.0% | Unchanged |
| RiverVest Venture Management LLC | 2,936,281 | $8.60M | 31.72% | 00.0% | Unchanged |
| Novo Holdings A/S | 6,722,336 | $19.7M | 1.32% | 00.0% | Unchanged |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −1,319,393−100.0% | Sold out |
| Bank of New York Mellon Corp | 0 | $0 | 0.00% | −89,120−100.0% | Sold out |
| Dimensional Fund Advisors LP | 0 | $0 | 0.00% | −32,452−100.0% | Sold out |
| Tower Research Capital LLC (TRC) | 0 | $0 | 0.00% | −4,356−100.0% | Sold out |
| FMR LLC | 0 | $0 | 0.00% | −36−100.0% | Sold out |