Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q1 2025
Institutional positions in Spruce Biosciences, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 31
- 0 vs. Q4 2024
- Shares held
- 10.5M
- −728.1K (−6.5%) vs. Q4 2024
- Total value
- $3.03M
- −$1.66M (−35.4%) vs. Q4 2024
- New holders
- 5
- 5 more added
- Sold out
- 5
- 7 more reduced
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| JPMorgan Chase & Co | 65 | $19 | 0.00% | −4−5.8% | Reduced |
| BNP Paribas Arbitrage, SA | 181 | $52 | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 233 | $68 | 0.00% | +11+5.0% | Added |
| Caldwell Sutter Capital, Inc. | 1,000 | $290 | 0.00% | 00.0% | Unchanged |
| Group One Trading, L.P. | 1,153 | $334 | 0.00% | −616−34.8% | Reduced |
| Tower Research Capital LLC (TRC) | 4,697 | $1.36K | 0.00% | −64−1.3% | Reduced |
| Morgan Stanley | 7,396 | $2.15K | 0.00% | +5,263+246.7% | Added |
| Citigroup Inc | 11,083 | $3.21K | 0.00% | +11,083 | New |
| Two Sigma Advisers, LP | 12,200 | $3.54K | 0.00% | −1,600−11.6% | Reduced |
| Marex Group plc | 14,800 | $4.29K | 0.00% | 00.0% | Unchanged |
| Ground Swell Capital, LLC | 17,312 | $5.02K | 0.01% | +17,312 | New |
| Two Sigma Investments, LP | 20,545 | $5.96K | 0.00% | −71−0.3% | Reduced |
| Northern Trust Corp | 32,721 | $9.49K | 0.00% | −47,587−59.3% | Reduced |
| Jane Street Group, LLC | 37,429 | $10.9K | 0.00% | +37,429 | New |
| Virtu Financial LLC | 39,426 | $11.0K | 0.00% | +39,426 | New |
| Shay Capital LLC | 38,119 | $11.1K | 0.00% | 00.0% | Unchanged |
| XTX Topco Ltd | 41,217 | $12.0K | 0.00% | +5,668+15.9% | Added |
| Two Sigma Securities, LLC | 47,686 | $13.8K | 0.00% | +47,686 | New |
| State Street Corp | 60,700 | $17.6K | 0.00% | 00.0% | Unchanged |
| Lion Point Capital, LP | 75,000 | $21.8K | 0.14% | 00.0% | Unchanged |
| UBS Group AG | 116,464 | $33.8K | 0.00% | +30,419+35.4% | Added |
| BlackRock, Inc. | 124,734 | $36.2K | 0.00% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 276,708 | $80.3K | 0.00% | +2,923+1.1% | Added |
| Boothbay Fund Management, LLC | 288,800 | $83.8K | 0.00% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 382,900 | $111.1K | 0.00% | −23,000−5.7% | Reduced |
| ADAR1 Capital Management, LLC | 403,716 | $117.1K | 0.02% | 00.0% | Unchanged |
| Vanguard Group Inc | 843,844 | $244.7K | 0.00% | 00.0% | Unchanged |
| Ikarian Capital, LLC | 1,000,000 | $290.1K | 0.09% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 1,045,828 | $301.0K | 0.00% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 2,609,125 | $756.9K | 0.04% | 00.0% | Unchanged |
| Carlyle Group Inc. | 2,896,518 | $840.3K | 0.02% | 00.0% | Unchanged |
| Sands Capital Ventures, LLC | 0 | $0 | 0.00% | −715,817−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −58,984−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −37,838−100.0% | Sold out |
| Bridgeway Capital Management, LLC | 0 | $0 | 0.00% | −34,900−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −4,857−100.0% | Sold out |