Opko Health, Inc.
OPK- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000944809
No open-market purchases or sales by Opko Health, Inc. insiders were filed in the last 90 days; 222 institutions reported holding it in 13F filings for Q2 2026, worth $303.4M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Opko Health, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 221
- −3 vs. Q3 2025
- Shares held
- 199.6M
- +3.58M (+1.8%) vs. Q3 2025
- Total value
- $251.1M
- −$52.0M (−17.2%) vs. Q3 2025
- New holders
- 30
- 43 more added
- Sold out
- 33
- 77 more reduced
9 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting OPK on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 222 | $303.4M |
| Q1 2026 | 236 | $229.4M |
| Q4 2025 | 221 | $251.1M |
| Q3 2025 | 233 | $303.6M |
| Q2 2025 | 222 | $270.4M |
| Q1 2025 | 255 | $401.4M |
| Q4 2024 | 235 | $290.3M |
| Q3 2024 | 234 | $278.1M |
| Q2 2024 | 232 | $227.7M |
| Q1 2024 | 224 | $190.7M |
| Q4 2023 | 218 | $256.6M |
| Q3 2023 | 225 | $267.6M |
| Q2 2023 | 230 | $375.6M |
| Q1 2023 | 227 | $259.3M |
| Q4 2022 | 221 | $224.8M |
| Q3 2022 | 221 | $349.6M |
| Q2 2022 | 231 | $479.9M |
| Q1 2022 | 229 | $671.0M |
| Q4 2021 | 236 | $914.8M |
| Q3 2021 | 206 | $668.9M |
| Q2 2021 | 234 | $773.3M |
| Q1 2021 | 239 | $817.1M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Opko Health, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Private Advisor Group, LLC | 55,301 | $69.7K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 55,140 | $69.5K | 0.00% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 54,022 | $68.0K | 0.00% | −32,995−37.9% | Reduced |
| Great West Life Assurance Co | 54,068 | $68.0K | 0.00% | 00.0% | Unchanged |
| Teacher Retirement System of Texas | 52,815 | $66.5K | 0.00% | −28,710−35.2% | Reduced |
| Transcend Wealth Collective, LLC | 52,741 | $66.5K | 0.01% | +176+0.3% | Added |
| First Manhattan Co | 51,750 | $65.2K | 0.00% | 00.0% | Unchanged |
| Verition Fund Management LLC | 50,650 | $63.8K | 0.00% | −28,884−36.3% | Reduced |
| Farmers National Bank | 50,300 | $63.4K | 0.01% | 00.0% | Unchanged |
| Victory Capital Management Inc | 45,025 | $56.7K | 0.00% | +3,721+9.0% | Added |
| Mariner, LLC | 42,225 | $53.3K | 0.00% | −26,781−38.8% | Reduced |
| RK Asset Management, LLC | 40,485 | $51.0K | 0.05% | 00.0% | Unchanged |
| Captrust Financial Advisors | 40,120 | $50.6K | 0.00% | −27,906−41.0% | Reduced |
| Hollencrest Capital Management | 40,000 | $50.4K | 0.00% | −50,000−55.6% | Reduced |
| Caitong International Asset Management Co., Ltd | 39,232 | $49.4K | 0.01% | +35,841+1,056.9% | Added |
| Raymond James Financial Inc | 38,744 | $48.8K | 0.00% | −23,461−37.7% | Reduced |
| HighTower Advisors, LLC | 37,453 | $47.2K | 0.00% | −2,954−7.3% | Reduced |
| The PNC Financial Services Group, Inc. | 37,000 | $46.6K | 0.00% | −20,050−35.1% | Reduced |
| RSM US Wealth Management LLC | 33,757 | $43.9K | 0.00% | 00.0% | Unchanged |
| Warren Averett Asset Management, LLC | 34,727 | $43.8K | 0.00% | +34,727 | New |
| Russell Investments Group, Ltd. | 34,690 | $43.7K | 0.00% | 00.0% | Unchanged |
| Xponance, Inc. | 32,361 | $40.8K | 0.00% | +191+0.6% | Added |
| Operose Advisors LLC | 32,000 | $40.3K | 0.01% | 00.0% | Unchanged |
| Diversify Wealth Management, LLC | 30,000 | $40.2K | 0.00% | 00.0% | Unchanged |
| STRS Ohio | 31,900 | $40.2K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 31,889 | $40.2K | 0.00% | 00.0% | Unchanged |
| Brinker Capital Investments, LLC | 30,000 | $37.8K | 0.00% | −96−0.3% | Reduced |
| Fisher Asset Management, LLC | 30,000 | $37.8K | 0.00% | 00.0% | Unchanged |
| IPG Investment Advisors LLC | 30,000 | $37.8K | 0.01% | 00.0% | Unchanged |
| EP Wealth Advisors, LLC | 29,446 | $37.1K | 0.00% | +29,446 | New |
| Atom Investors LP | 28,258 | $35.6K | 0.00% | −13,614−32.5% | Reduced |
| CIBC World Markets Corp | 27,225 | $34.3K | 0.00% | +27,225 | New |
| Mackenzie Financial Corp | 25,843 | $33.5K | 0.00% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 26,437 | $33.3K | 0.00% | −12,660−32.4% | Reduced |
| Prudential Financial Inc | 26,366 | $33.2K | 0.00% | −28,406−51.9% | Reduced |
| Cim Investment Mangement Inc | 25,804 | $32.5K | 0.01% | 00.0% | Unchanged |
| SlateStone Wealth, LLC | 25,770 | $32.0K | 0.00% | 00.0% | Unchanged |
| Arrow Financial Corp | 25,000 | $31.5K | 0.00% | 00.0% | Unchanged |
| Sterling Capital Management LLC | 23,720 | $29.9K | 0.00% | −4,676−16.5% | Reduced |
| LPL Financial LLC | 22,458 | $28.3K | 0.00% | −8,477−27.4% | Reduced |
| CIBC Asset Management Inc | 21,918 | $27.6K | 0.00% | 00.0% | Unchanged |
| StoneX Group Inc. | 21,599 | $27.2K | 0.00% | +21,599 | New |
| Zacks Investment Management | 21,322 | $26.9K | 0.00% | +21,322 | New |
| Sax Wealth Advisors, LLC | 20,298 | $25.6K | 0.00% | −82−0.4% | Reduced |
| Capital Advisors Inc | 370,000 | $25.3K | 0.00% | 00.0% | Unchanged |
| Cumberland Advisors Inc | 19,500 | $24.6K | 0.01% | 00.0% | Unchanged |
| Swiss Life Asset Management Ltd | 19,164 | $24.1K | 0.00% | 00.0% | Unchanged |
| Westmount Partners, LLC | 18,550 | $23.4K | 0.01% | +2,000+12.1% | Added |
| Principal Financial Group Inc | 17,752 | $22.4K | 0.00% | −10,985−38.2% | Reduced |
| Quantinno Capital Management LP | 17,716 | $22.3K | 0.00% | +17,716 | New |
| Cerity Partners LLC | 17,382 | $21.9K | 0.00% | −17,184−49.7% | Reduced |
| CIBC World Markets Inc. | 17,228 | $21.7K | 0.00% | −12,700−42.4% | Reduced |
| Shufro Rose & Co LLC | 17,000 | $21.4K | 0.00% | 00.0% | Unchanged |
| CAPROCK Group, Inc. | 16,770 | $21.1K | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 16,542 | $20.8K | 0.00% | −16,206−49.5% | Reduced |
| Commons Capital, LLC | 16,300 | $20.5K | 0.01% | 00.0% | Unchanged |
| Sigma Planning Corp | 15,807 | $19.9K | 0.00% | 00.0% | Unchanged |
| Stifel Financial Corp | 15,358 | $19.4K | 0.00% | −1,500−8.9% | Reduced |
| Jump Financial, LLC | 15,277 | $19.2K | 0.00% | +15,277 | New |
| Key Financial Inc | 15,250 | $19.2K | 0.00% | +4,250+38.6% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 14,823 | $18.7K | 0.00% | 00.0% | Unchanged |
| Sanctuary Advisors, LLC | 14,758 | $18.6K | 0.00% | −909−5.8% | Reduced |
| Colony Family Offices, LLC | 14,729 | $18.6K | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 14,125 | $17.8K | 0.00% | 00.0% | Unchanged |
| FMR LLC | 14,087 | $17.8K | 0.00% | −2,477−15.0% | Reduced |
| Formidable Asset Management, LLC | 11,296 | $17.5K | 0.00% | −3,000−21.0% | Reduced |
| Amalgamated Bank | 12,929 | $16.0K | 0.00% | +1,819+16.4% | Added |
| Mill Creek Capital Advisors, LLC | 12,383 | $15.6K | 0.00% | 00.0% | Unchanged |
| Traphagen Investment Advisors LLC | 11,680 | $14.7K | 0.00% | 00.0% | Unchanged |
| Buckingham Strategic Partners | 11,664 | $14.7K | 0.00% | −6,367−35.3% | Reduced |
| Atomi Financial Group, Inc. | 11,500 | $14.5K | 0.00% | +11,500 | New |
| HBK Sorce Advisory LLC | 11,057 | $13.7K | 0.00% | −2,470−18.3% | Reduced |
| ExodusPoint Capital Management, LP | 10,637 | $13.4K | 0.00% | +10,637 | New |
| Diversified Trust Co | 10,374 | $13.1K | 0.00% | 00.0% | Unchanged |
| SEI Investments Co | 10,163 | $12.8K | 0.00% | 00.0% | Unchanged |
| KLCM Advisors, Inc. | 10,000 | $12.6K | 0.00% | 00.0% | Unchanged |
| Greenbush Financial Group, LLC | 10,000 | $12.6K | 0.00% | 00.0% | Unchanged |
| MRP Capital Investments, LLC | 10,000 | $12.6K | 0.01% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 9,128 | $11.5K | 0.00% | −12,415−57.6% | Reduced |
| Aventura Private Wealth, LLC | 8,400 | $10.6K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 8,151 | $10.3K | 0.00% | +2,166+36.2% | Added |
| Steward Partners Investment Advisory, LLC | 7,110 | $8.96K | 0.00% | 00.0% | Unchanged |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 6,045 | $8.00K | 0.00% | +2,268+60.0% | Added |
| National Bank of Canada | 6,200 | $7.75K | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 5,625 | $7.09K | 0.00% | −1,168−17.2% | Reduced |
| CIBC Private Wealth Group, LLC | 5,000 | $6.30K | 0.00% | +5,000 | New |
| Altshuler Shaham Ltd | 3,292 | $4.21K | 0.00% | +2,160+190.8% | Added |
| Gables Capital Management Inc. | 3,000 | $3.78K | 0.00% | 00.0% | Unchanged |
| Smartleaf Asset Management LLC | 2,757 | $3.58K | 0.00% | 00.0% | Unchanged |
| Essential Partners LLC | 1,716 | $2.16K | 0.00% | −3,666−68.1% | Reduced |
| CoreCap Advisors, LLC | 1,600 | $2.02K | 0.00% | 00.0% | Unchanged |
| Aster Capital Management (DIFC) Ltd | 1,408 | $1.77K | 0.00% | −3,272−69.9% | Reduced |
| Optiver Holding B.V. | 1,393 | $1.75K | 0.00% | −1,363−49.5% | Reduced |
| Nisa Investment Advisors, LLC | 1,312 | $1.65K | 0.00% | −3,160−70.7% | Reduced |
| Godfrey Financial Associates, Inc. | 1,250 | $1.57K | 0.00% | +1,250 | New |
| PFS Partners, LLC | 1,100 | $1.39K | 0.00% | 00.0% | Unchanged |
| Salomon & Ludwin, LLC | 921 | $1.18K | 0.00% | −30−3.2% | Reduced |
| True Wealth Design, LLC | 872 | $1.10K | 0.00% | +6+0.7% | Added |
| US Bancorp | 500 | $630 | 0.00% | −600−54.5% | Reduced |
| Rothschild Investment LLC | 449 | $566 | 0.00% | −230−33.9% | Reduced |