Opko Health, Inc.
OPK- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000944809
No open-market purchases or sales by Opko Health, Inc. insiders were filed in the last 90 days; 222 institutions reported holding it in 13F filings for Q2 2026, worth $303.4M in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Opko Health, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 233
- +16 vs. Q2 2025
- Shares held
- 196.3M
- −8.63M (−4.2%) vs. Q2 2025
- Total value
- $303.6M
- +$33.5M (+12.4%) vs. Q2 2025
- New holders
- 30
- 77 more added
- Sold out
- 14
- 53 more reduced
5 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting OPK on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 222 | $303.4M |
| Q1 2026 | 236 | $229.4M |
| Q4 2025 | 221 | $251.1M |
| Q3 2025 | 233 | $303.6M |
| Q2 2025 | 222 | $270.4M |
| Q1 2025 | 255 | $401.4M |
| Q4 2024 | 235 | $290.3M |
| Q3 2024 | 234 | $278.1M |
| Q2 2024 | 232 | $227.7M |
| Q1 2024 | 224 | $190.7M |
| Q4 2023 | 218 | $256.6M |
| Q3 2023 | 225 | $267.6M |
| Q2 2023 | 230 | $375.6M |
| Q1 2023 | 227 | $259.3M |
| Q4 2022 | 221 | $224.8M |
| Q3 2022 | 221 | $349.6M |
| Q2 2022 | 231 | $479.9M |
| Q1 2022 | 229 | $671.0M |
| Q4 2021 | 236 | $914.8M |
| Q3 2021 | 206 | $668.9M |
| Q2 2021 | 234 | $773.3M |
| Q1 2021 | 239 | $817.1M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Opko Health, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Rubric Capital Management LP | 47,791,243 | $74.1M | 0.99% | 00.0% | Unchanged |
| Vanguard Group Inc | 37,535,897 | $58.2M | 0.00% | −702,817−1.8% | Reduced |
| BlackRock, Inc. | 33,172,384 | $51.4M | 0.00% | +1,722,902+5.5% | Added |
| Geode Capital Management, LLC | 10,993,345 | $17.0M | 0.00% | +568,872+5.5% | Added |
| State Street Corp | 8,997,940 | $13.9M | 0.00% | +416,100+4.8% | Added |
| Whitefort Capital Management, LP | 4,900,000 | $7.59M | 2.51% | +3,125,800+176.2% | Added |
| UBS Group AG | 4,775,536 | $7.40M | 0.00% | −944,096−16.5% | Reduced |
| Charles Schwab Investment Management Inc | 3,768,934 | $5.84M | 0.00% | +418,558+12.5% | Added |
| Northern Trust Corp | 3,657,846 | $5.67M | 0.00% | +175,574+5.0% | Added |
| AQR Capital Management LLC | 2,873,416 | $4.45M | 0.00% | +1,937,516+207.0% | Added |
| Goldman Sachs Group Inc | 2,386,535 | $3.70M | 0.00% | −433,520−15.4% | Reduced |
| AWM Investment Company, Inc. | 2,200,000 | $3.41M | 0.32% | +200,000+10.0% | Added |
| Dimensional Fund Advisors LP | 1,667,368 | $2.58M | 0.00% | −262,315−13.6% | Reduced |
| Y.D. More Investments Ltd | 1,499,118 | $2.24M | 0.13% | −29,781−1.9% | Reduced |
| Washington Growth Strategies LLC | 1,356,124 | $2.10M | 1.50% | 00.0% | Unchanged |
| PFG Investments, LLC | 1,337,375 | $2.07M | 0.11% | +72,250+5.7% | Added |
| Bank of America Corp | 1,313,882 | $2.04M | 0.00% | −592,957−31.1% | Reduced |
| Bank of New York Mellon Corp | 1,276,868 | $1.98M | 0.00% | +127,962+11.1% | Added |
| Two Sigma Investments, LP | 1,255,647 | $1.95M | 0.00% | −581,100−31.6% | Reduced |
| Voya Investment Management LLC | 1,218,002 | $1.89M | 0.00% | −101,559−7.7% | Reduced |
| Weiss Asset Management LP | 1,130,771 | $1.75M | 0.03% | −3,626,221−76.2% | Reduced |
| Invesco Ltd. | 1,017,561 | $1.58M | 0.00% | −353,484−25.8% | Reduced |
| Tejara Capital Ltd | 877,941 | $1.36M | 0.75% | −68,149−7.2% | Reduced |
| Swiss National Bank | 845,755 | $1.31M | 0.00% | +268,400+46.5% | Added |
| Nuveen, LLC | 841,836 | $1.30M | 0.00% | −284,721−25.3% | Reduced |
| Morgan Stanley | 837,601 | $1.30M | 0.00% | −1,221,453−59.3% | Reduced |
| UBS Asset Management Americas Inc | 673,565 | $1.04M | 0.00% | −453,911−40.3% | Reduced |
| Assenagon Asset Management S.A. | 690,200 | $1.03M | 0.00% | −244,900−26.2% | Reduced |
| Commonwealth Equity Services, LLC | 592,330 | $918.0K | 0.00% | +37,932+6.8% | Added |
| Barclays PLC | 587,753 | $911.0K | 0.00% | −76,654−11.5% | Reduced |
| Rhumbline Advisers | 555,382 | $860.8K | 0.00% | +25,829+4.9% | Added |
| JPMorgan Chase & Co | 527,411 | $817.5K | 0.00% | −102,944−16.3% | Reduced |
| Alliancebernstein L.P. | 475,190 | $736.5K | 0.00% | +6,900+1.5% | Added |
| California State Teachers Retirement System | 415,386 | $643.8K | 0.00% | +91,269+28.2% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 392,761 | $608.8K | 0.00% | +1,097+0.3% | Added |
| Legal & General Group Plc | 386,837 | $598.2K | 0.00% | +31,155+8.8% | Added |
| Two Sigma Advisers, LP | 344,097 | $533.4K | 0.00% | −304,200−46.9% | Reduced |
| Price T Rowe Associates Inc | 343,286 | $533.0K | 0.00% | −94,220−21.5% | Reduced |
| Wells Fargo & Company | 342,486 | $530.9K | 0.00% | +71,392+26.3% | Added |
| Susquehanna International Group, LLP | 297,835 | $461.6K | 0.00% | −346,835−53.8% | Reduced |
| Citadel Advisors LLC | 279,875 | $433.8K | 0.00% | +62,480+28.7% | Added |
| Ieq Capital, LLC | 277,594 | $430.3K | 0.00% | +168,375+154.2% | Added |
| Deutsche Bank AG | 275,188 | $426.5K | 0.00% | +36,170+15.1% | Added |
| Royal Bank of Canada | 272,866 | $423.0K | 0.00% | +5,418+2.0% | Added |
| Jane Street Group, LLC | 262,838 | $407.4K | 0.00% | −1,121,714−81.0% | Reduced |
| Tudor Investment Corp Et Al | 244,821 | $379.5K | 0.00% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 236,722 | $366.9K | 0.00% | +98,079+70.7% | Added |
| Zazove Associates LLC | 207,600 | $321.8K | 0.03% | 00.0% | Unchanged |
| MetLife Investment Management | 207,175 | $321.1K | 0.00% | −11,097−5.1% | Reduced |
| Janus Henderson Group PLC | 206,314 | $318.8K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global ETFs Holdings Ltd. | 191,186 | $296.3K | 0.00% | −6,962−3.5% | Reduced |
| State Board of Administration of Florida Retirement System | 176,260 | $273.2K | 0.00% | 00.0% | Unchanged |
| Gamco Investors, Inc. Et Al | 175,000 | $271.3K | 0.00% | 00.0% | Unchanged |
| Gabelli Funds LLC | 170,000 | $263.5K | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 150,566 | $233.0K | 0.01% | +150,566 | New |
| SIH Partners, LLLP | 150,125 | $232.7K | 0.02% | +80,706+116.3% | Added |
| Intech Investment Management LLC | 143,323 | $222.2K | 0.00% | +1,699+1.2% | Added |
| Teton Advisors, LLC | 142,000 | $220.1K | 0.14% | +142,000 | New |
| State of Wyoming | 135,954 | $210.7K | 0.02% | +53,947+65.8% | Added |
| New York State Common Retirement Fund | 130,901 | $202.9K | 0.00% | +70,100+115.3% | Added |
| Arizona State Retirement System | 128,608 | $199.3K | 0.00% | +40,414+45.8% | Added |
| CWM, LLC | 124,774 | $193.0K | 0.00% | +102,184+452.3% | Added |
| Two Sigma Securities, LLC | 121,094 | $187.7K | 0.03% | +121,094 | New |
| BNP Paribas Arbitrage, SA | 118,309 | $183.4K | 0.00% | −463,362−79.7% | Reduced |
| Csenge Advisory Group | 117,001 | $181.4K | 0.01% | +10.0% | Added |
| Highline Wealth Partners LLC | 116,681 | $180.9K | 0.05% | +10.0% | Added |
| Humankind Investments LLC | 114,644 | $177.7K | 0.04% | +5,345+4.9% | Added |
| Glenmede Investment Management, LP | 113,413 | $175.8K | 0.00% | +663+0.6% | Added |
| Comerica Bank | 112,000 | $173.6K | 0.00% | 00.0% | Unchanged |
| Van Eck Associates Corp | 111,826 | $173.0K | 0.00% | −7,215−6.1% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 102,397 | $158.7K | 0.00% | +24,948+32.2% | Added |
| Phoenix Holdings Ltd. | 100,000 | $155.9K | 0.00% | 00.0% | Unchanged |
| RPg Family Wealth Advisory, LLC | 98,990 | $153.4K | 0.03% | +98,990 | New |
| Graham Capital Management, L.P. | 98,368 | $152.5K | 0.01% | −1,812,763−94.9% | Reduced |
| Cambridge Investment Research Advisors, Inc. | 96,511 | $150.0K | 0.00% | −6,600−6.4% | Reduced |
| Ameriprise Financial Inc | 95,241 | $147.6K | 0.00% | +481+0.5% | Added |
| 360 Financial, Inc. | 91,300 | $141.5K | 0.05% | +2,500+2.8% | Added |
| Hollencrest Capital Management | 90,000 | $139.5K | 0.01% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 87,017 | $135.0K | 0.00% | −119,358−57.8% | Reduced |
| Teacher Retirement System of Texas | 81,525 | $126.4K | 0.00% | +30,248+59.0% | Added |
| Creative Planning | 80,796 | $125.2K | 0.00% | +56,304+229.9% | Added |
| Advisor Group Holdings, Inc. | 86,775 | $123.6K | 0.00% | −7,701−8.2% | Reduced |
| Verition Fund Management LLC | 79,534 | $123.3K | 0.00% | +28,884+57.0% | Added |
| Mercer Global Advisors Inc | 77,886 | $120.7K | 0.00% | +38,352+97.0% | Added |
| Wealth Enhancement Advisory Services, LLC | 75,749 | $116.7K | 0.00% | +38,755+104.8% | Added |
| KLP Kapitalforvaltning AS | 74,000 | $114.7K | 0.00% | 00.0% | Unchanged |
| Cubist Systematic Strategies, LLC | 72,127 | $111.8K | 0.00% | −61,532−46.0% | Reduced |
| ProShare Advisors LLC | 70,369 | $109.1K | 0.00% | −3,815−5.1% | Reduced |
| Mariner, LLC | 69,006 | $107.0K | 0.00% | +44,914+186.4% | Added |
| Captrust Financial Advisors | 68,026 | $105.4K | 0.00% | +26,099+62.2% | Added |
| Cascade Financial Partners, LLC | 66,490 | $103.1K | 0.01% | 00.0% | Unchanged |
| Pictet Asset Management Holding SA | 65,495 | $101.5K | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 63,780 | $98.9K | 0.00% | +63,780 | New |
| Raymond James Financial Inc | 62,205 | $96.4K | 0.00% | −3,965−6.0% | Reduced |
| Public Employees Retirement Association of Colorado | 61,502 | $95.0K | 0.00% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 59,700 | $92.5K | 0.00% | +21,600+56.7% | Added |
| Brighton Jones LLC | 59,426 | $92.1K | 0.00% | +20,510+52.7% | Added |
| Cetera Investment Advisers | 59,051 | $91.5K | 0.00% | −1,506−2.5% | Reduced |
| Kestra Private Wealth Services, LLC | 58,450 | $90.6K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 57,050 | $88.4K | 0.00% | +250+0.4% | Added |