Opko Health, Inc.
OPK- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000944809
No open-market purchases or sales by Opko Health, Inc. insiders were filed in the last 90 days; 222 institutions reported holding it in 13F filings for Q2 2026, worth $303.4M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Opko Health, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 221
- −3 vs. Q3 2025
- Shares held
- 199.6M
- +3.58M (+1.8%) vs. Q3 2025
- Total value
- $251.1M
- −$52.0M (−17.2%) vs. Q3 2025
- New holders
- 30
- 43 more added
- Sold out
- 33
- 77 more reduced
9 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting OPK on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 222 | $303.4M |
| Q1 2026 | 236 | $229.4M |
| Q4 2025 | 221 | $251.1M |
| Q3 2025 | 233 | $303.6M |
| Q2 2025 | 222 | $270.4M |
| Q1 2025 | 255 | $401.4M |
| Q4 2024 | 235 | $290.3M |
| Q3 2024 | 234 | $278.1M |
| Q2 2024 | 232 | $227.7M |
| Q1 2024 | 224 | $190.7M |
| Q4 2023 | 218 | $256.6M |
| Q3 2023 | 225 | $267.6M |
| Q2 2023 | 230 | $375.6M |
| Q1 2023 | 227 | $259.3M |
| Q4 2022 | 221 | $224.8M |
| Q3 2022 | 221 | $349.6M |
| Q2 2022 | 231 | $479.9M |
| Q1 2022 | 229 | $671.0M |
| Q4 2021 | 236 | $914.8M |
| Q3 2021 | 206 | $668.9M |
| Q2 2021 | 234 | $773.3M |
| Q1 2021 | 239 | $817.1M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Opko Health, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Rubric Capital Management LP | 47,791,243 | $60.2M | 0.72% | 00.0% | Unchanged |
| BlackRock, Inc. | 34,852,030 | $43.9M | 0.00% | +1,679,646+5.1% | Added |
| Vanguard Group Inc | 32,457,788 | $40.9M | 0.00% | −5,078,109−13.5% | Reduced |
| Geode Capital Management, LLC | 11,061,318 | $13.9M | 0.00% | +67,973+0.6% | Added |
| State Street Corp | 8,951,762 | $11.3M | 0.00% | −46,178−0.5% | Reduced |
| Goldman Sachs Group Inc | 5,986,913 | $7.54M | 0.00% | +3,600,378+150.9% | Added |
| UBS Group AG | 5,352,784 | $6.74M | 0.00% | +577,248+12.1% | Added |
| Whitefort Capital Management, LP | 4,253,340 | $5.36M | 1.62% | −646,660−13.2% | Reduced |
| Charles Schwab Investment Management Inc | 3,692,650 | $4.65M | 0.00% | −76,284−2.0% | Reduced |
| Northern Trust Corp | 3,438,312 | $4.33M | 0.00% | −219,534−6.0% | Reduced |
| Citadel Advisors LLC | 2,857,433 | $3.60M | 0.00% | +2,577,558+921.0% | Added |
| AWM Investment Company, Inc. | 2,100,000 | $2.65M | 0.26% | −100,000−4.5% | Reduced |
| AQR Capital Management LLC | 2,026,957 | $2.55M | 0.00% | −846,459−29.5% | Reduced |
| Jane Street Group, LLC | 1,775,336 | $2.24M | 0.00% | +1,512,498+575.4% | Added |
| Dimensional Fund Advisors LP | 1,611,318 | $2.03M | 0.00% | −56,050−3.4% | Reduced |
| Washington Growth Strategies LLC | 1,356,124 | $1.71M | 1.10% | 00.0% | Unchanged |
| Y.D. More Investments Ltd | 1,306,452 | $1.67M | 0.08% | −192,666−12.9% | Reduced |
| PFG Investments, LLC | 1,320,391 | $1.66M | 0.08% | −16,984−1.3% | Reduced |
| Bank of New York Mellon Corp | 1,310,094 | $1.65M | 0.00% | +33,226+2.6% | Added |
| Voya Investment Management LLC | 1,102,174 | $1.39M | 0.00% | −115,828−9.5% | Reduced |
| Morgan Stanley | 917,353 | $1.16M | 0.00% | +79,752+9.5% | Added |
| Clearstead Advisors, LLC | 882,367 | $1.11M | 0.01% | +882,367 | New |
| Tejara Capital Ltd | 877,941 | $1.11M | 0.46% | 00.0% | Unchanged |
| Swiss National Bank | 845,755 | $1.07M | 0.00% | 00.0% | Unchanged |
| Nuveen, LLC | 841,836 | $1.06M | 0.00% | 00.0% | Unchanged |
| Invesco Ltd. | 781,672 | $984.9K | 0.00% | −235,889−23.2% | Reduced |
| Two Sigma Investments, LP | 734,747 | $925.8K | 0.00% | −520,900−41.5% | Reduced |
| HRT Financial LP | 675,483 | $851.0K | 0.00% | +675,483 | New |
| UBS Asset Management Americas Inc | 673,565 | $848.7K | 0.00% | 00.0% | Unchanged |
| Barclays PLC | 663,236 | $835.7K | 0.00% | +75,483+12.8% | Added |
| Assenagon Asset Management S.A. | 652,066 | $834.7K | 0.00% | −38,134−5.5% | Reduced |
| Commonwealth Equity Services, LLC | 641,456 | $808.2K | 0.00% | +49,126+8.3% | Added |
| Gsa Capital Partners LLP | 621,328 | $783.0K | 0.07% | +621,328 | New |
| Bank of America Corp | 618,259 | $779.0K | 0.00% | −695,623−52.9% | Reduced |
| JPMorgan Chase & Co | 579,778 | $730.5K | 0.00% | +52,367+9.9% | Added |
| Rhumbline Advisers | 511,479 | $644.5K | 0.00% | −43,903−7.9% | Reduced |
| Wells Fargo & Company | 468,518 | $590.3K | 0.00% | +126,032+36.8% | Added |
| Legal & General Group Plc | 453,265 | $571.1K | 0.00% | +66,428+17.2% | Added |
| Alliancebernstein L.P. | 448,190 | $564.7K | 0.00% | −27,000−5.7% | Reduced |
| Susquehanna International Group, LLP | 437,287 | $551.0K | 0.00% | +139,452+46.8% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 430,630 | $542.6K | 0.00% | +37,869+9.6% | Added |
| California State Teachers Retirement System | 417,088 | $525.5K | 0.00% | +1,702+0.4% | Added |
| Two Sigma Securities, LLC | 374,468 | $471.8K | 0.06% | +253,374+209.2% | Added |
| Price T Rowe Associates Inc | 367,191 | $463.0K | 0.00% | +23,905+7.0% | Added |
| XTX Topco Ltd | 342,757 | $431.9K | 0.01% | +342,757 | New |
| Deutsche Bank AG | 325,889 | $410.6K | 0.00% | +50,701+18.4% | Added |
| EntryPoint Capital, LLC | 309,024 | $389.4K | 0.15% | +270,196+695.9% | Added |
| Millennium Management LLC | 265,268 | $334.2K | 0.00% | +265,268 | New |
| Royal Bank of Canada | 261,020 | $329.0K | 0.00% | −11,846−4.3% | Reduced |
| Tudor Investment Corp Et Al | 244,821 | $308.5K | 0.00% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 229,590 | $289.3K | 0.00% | −7,132−3.0% | Reduced |
| Janus Henderson Group PLC | 206,314 | $258.9K | 0.00% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 198,821 | $250.5K | 0.00% | +198,821 | New |
| Mirabella Financial Services LLP | 193,722 | $244.1K | 0.02% | +193,722 | New |
| Two Sigma Advisers, LP | 191,201 | $240.9K | 0.00% | −152,896−44.4% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 191,104 | $240.8K | 0.00% | −820.0% | Reduced |
| State Board of Administration of Florida Retirement System | 176,260 | $222.1K | 0.00% | 00.0% | Unchanged |
| MetLife Investment Management | 175,676 | $221.4K | 0.00% | −31,499−15.2% | Reduced |
| Gamco Investors, Inc. Et Al | 175,000 | $220.5K | 0.00% | 00.0% | Unchanged |
| Gabelli Funds LLC | 170,000 | $214.2K | 0.00% | 00.0% | Unchanged |
| Intech Investment Management LLC | 159,652 | $201.2K | 0.00% | +16,329+11.4% | Added |
| Ieq Capital, LLC | 157,779 | $198.8K | 0.00% | −119,815−43.2% | Reduced |
| ProShare Advisors LLC | 156,354 | $197.0K | 0.00% | +85,985+122.2% | Added |
| Zazove Associates LLC | 150,000 | $189.0K | 0.02% | −57,600−27.7% | Reduced |
| Teton Advisors, LLC | 140,000 | $176.4K | 0.12% | −2,000−1.4% | Reduced |
| Van Eck Associates Corp | 137,019 | $173.0K | 0.00% | +25,193+22.5% | Added |
| Quantbot Technologies LP | 122,747 | $154.7K | 0.01% | +122,747 | New |
| Comerica Bank | 120,000 | $151.2K | 0.00% | +8,000+7.1% | Added |
| Graham Capital Management, L.P. | 119,654 | $150.8K | 0.01% | +21,286+21.6% | Added |
| Highline Wealth Partners LLC | 116,681 | $147.0K | 0.04% | 00.0% | Unchanged |
| Virtu Financial LLC | 115,298 | $145.0K | 0.01% | +115,298 | New |
| New York State Common Retirement Fund | 114,301 | $144.0K | 0.00% | −16,600−12.7% | Reduced |
| Arizona State Retirement System | 113,834 | $143.4K | 0.00% | −14,774−11.5% | Reduced |
| Glenmede Trust Co NA | 113,483 | $143.0K | 0.00% | +113,483 | New |
| Y-Intercept (Hong Kong) Ltd | 112,930 | $142.3K | 0.00% | +112,930 | New |
| SIH Partners, LLLP | 104,334 | $131.5K | 0.01% | −45,791−30.5% | Reduced |
| Qube Research & Technologies Ltd | 102,763 | $129.5K | 0.00% | +102,763 | New |
| Police & Firemen's Retirement System of New Jersey | 102,397 | $129.0K | 0.00% | 00.0% | Unchanged |
| RPg Family Wealth Advisory, LLC | 98,990 | $124.7K | 0.03% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 96,242 | $121.3K | 0.00% | +1,001+1.1% | Added |
| Simplex Trading, LLC | 93,881 | $118.3K | 0.00% | −56,685−37.6% | Reduced |
| Quadrature Capital Ltd | 91,702 | $115.5K | 0.00% | +91,702 | New |
| KLP Kapitalforvaltning AS | 90,700 | $114.3K | 0.00% | +16,700+22.6% | Added |
| BNP Paribas Arbitrage, SA | 90,433 | $113.9K | 0.00% | −27,876−23.6% | Reduced |
| Cambridge Investment Research Advisors, Inc. | 89,721 | $113.0K | 0.00% | −6,790−7.0% | Reduced |
| Headlands Technologies LLC | 88,962 | $112.1K | 0.01% | +43,722+96.6% | Added |
| 360 Financial, Inc. | 87,300 | $110.0K | 0.03% | −4,000−4.4% | Reduced |
| Brevan Howard Capital Management LP | 85,348 | $107.5K | 0.00% | +85,348 | New |
| Advisor Group Holdings, Inc. | 75,315 | $94.9K | 0.00% | −11,460−13.2% | Reduced |
| CWM, LLC | 69,147 | $87.0K | 0.00% | −55,627−44.6% | Reduced |
| Pensionmark Financial Group, LLC | 66,520 | $83.8K | 0.00% | +25,902+63.8% | Added |
| Cascade Financial Partners, LLC | 66,490 | $83.8K | 0.01% | 00.0% | Unchanged |
| Pictet Asset Management Holding SA | 65,495 | $82.5K | 0.00% | 00.0% | Unchanged |
| Public Employees Retirement Association of Colorado | 61,502 | $77.0K | 0.00% | 00.0% | Unchanged |
| Wealth Enhancement Advisory Services, LLC | 57,529 | $75.9K | 0.00% | −18,220−24.1% | Reduced |
| Wellington Grp LLC | 60,000 | $75.6K | 0.03% | +60,000 | New |
| Cetera Investment Advisers | 59,163 | $74.5K | 0.00% | +112+0.2% | Added |
| Mercer Global Advisors Inc | 59,026 | $74.4K | 0.00% | −18,860−24.2% | Reduced |
| Kestra Private Wealth Services, LLC | 58,450 | $73.6K | 0.00% | 00.0% | Unchanged |
| Creative Planning | 58,061 | $73.2K | 0.00% | −22,735−28.1% | Reduced |