Opko Health, Inc.
OPK- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000944809
No open-market purchases or sales by Opko Health, Inc. insiders were filed in the last 90 days; 222 institutions reported holding it in 13F filings for Q2 2026, worth $303.4M in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Opko Health, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 236
- +21 vs. Q4 2025
- Shares held
- 201.2M
- +34.3M (+20.5%) vs. Q4 2025
- Total value
- $229.4M
- +$19.5M (+9.3%) vs. Q4 2025
- New holders
- 44
- 59 more added
- Sold out
- 23
- 62 more reduced
6 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting OPK on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 222 | $303.4M |
| Q1 2026 | 236 | $229.4M |
| Q4 2025 | 221 | $251.1M |
| Q3 2025 | 233 | $303.6M |
| Q2 2025 | 222 | $270.4M |
| Q1 2025 | 255 | $401.4M |
| Q4 2024 | 235 | $290.3M |
| Q3 2024 | 234 | $278.1M |
| Q2 2024 | 232 | $227.7M |
| Q1 2024 | 224 | $190.7M |
| Q4 2023 | 218 | $256.6M |
| Q3 2023 | 225 | $267.6M |
| Q2 2023 | 230 | $375.6M |
| Q1 2023 | 227 | $259.3M |
| Q4 2022 | 221 | $224.8M |
| Q3 2022 | 221 | $349.6M |
| Q2 2022 | 231 | $479.9M |
| Q1 2022 | 229 | $671.0M |
| Q4 2021 | 236 | $914.8M |
| Q3 2021 | 206 | $668.9M |
| Q2 2021 | 234 | $773.3M |
| Q1 2021 | 239 | $817.1M |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Opko Health, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Rubric Capital Management LP | 47,791,243 | $54.5M | 0.67% | 00.0% | Unchanged |
| BlackRock, Inc. | 36,232,223 | $41.3M | 0.00% | +1,380,193+4.0% | Added |
| Vanguard Portfolio Management LLC | 14,769,719 | $16.8M | 0.00% | +14,769,719 | New |
| Vanguard Capital Management LLC | 14,499,164 | $16.5M | 0.00% | +14,499,164 | New |
| Geode Capital Management, LLC | 11,301,501 | $12.9M | 0.00% | +240,183+2.2% | Added |
| State Street Corp | 9,501,377 | $10.8M | 0.00% | +549,615+6.1% | Added |
| Goldman Sachs Group Inc | 7,675,026 | $8.75M | 0.00% | +1,688,113+28.2% | Added |
| UBS Group AG | 6,071,432 | $6.92M | 0.00% | +718,648+13.4% | Added |
| Whitefort Capital Management, LP | 4,253,340 | $4.85M | 1.48% | 00.0% | Unchanged |
| Northern Trust Corp | 3,619,346 | $4.13M | 0.00% | +181,034+5.3% | Added |
| Charles Schwab Investment Management Inc | 3,574,039 | $4.07M | 0.00% | −118,611−3.2% | Reduced |
| Vanguard Fiduciary Trust Co | 2,742,017 | $3.13M | 0.00% | +2,742,017 | New |
| AWM Investment Company, Inc. | 2,100,000 | $2.39M | 0.27% | 00.0% | Unchanged |
| Citadel Advisors LLC | 2,079,547 | $2.37M | 0.00% | −777,886−27.2% | Reduced |
| Dimensional Fund Advisors LP | 1,560,000 | $1.78M | 0.00% | −51,318−3.2% | Reduced |
| Washington Growth Strategies LLC | 1,356,124 | $1.55M | 1.01% | 00.0% | Unchanged |
| Y.D. More Investments Ltd | 1,299,473 | $1.47M | 0.06% | −6,979−0.5% | Reduced |
| Bank of New York Mellon Corp | 1,280,042 | $1.46M | 0.00% | −30,052−2.3% | Reduced |
| Morgan Stanley | 1,196,087 | $1.36M | 0.00% | +278,734+30.4% | Added |
| Voya Investment Management LLC | 1,160,927 | $1.32M | 0.00% | +58,753+5.3% | Added |
| Bank of America Corp | 1,141,849 | $1.30M | 0.00% | +523,590+84.7% | Added |
| Jane Street Group, LLC | 1,114,375 | $1.27M | 0.00% | −660,961−37.2% | Reduced |
| PFG Investments, LLC | 1,112,776 | $1.27M | 0.06% | −207,615−15.7% | Reduced |
| OP Asset Management Ltd | 1,102,254 | $1.26M | 0.01% | +1,102,254 | New |
| Clearstead Advisors, LLC | 884,119 | $1.01M | 0.01% | +1,752+0.2% | Added |
| Tejara Capital Ltd | 877,941 | $1.00M | 0.33% | 00.0% | Unchanged |
| Nuveen, LLC | 846,993 | $965.6K | 0.00% | +5,157+0.6% | Added |
| Swiss National Bank | 845,755 | $964.2K | 0.00% | 00.0% | Unchanged |
| Invesco Ltd. | 793,169 | $904.2K | 0.00% | +11,497+1.5% | Added |
| AQR Capital Management LLC | 763,590 | $870.5K | 0.00% | −1,263,367−62.3% | Reduced |
| UBS Asset Management Americas Inc | 674,848 | $769.3K | 0.00% | +1,283+0.2% | Added |
| Gsa Capital Partners LLP | 663,704 | $757.0K | 0.05% | +42,376+6.8% | Added |
| Assenagon Asset Management S.A. | 652,066 | $740.3K | 0.00% | 00.0% | Unchanged |
| Connor, Clark & Lunn Investment Management Ltd. | 522,906 | $596.1K | 0.00% | +92,276+21.4% | Added |
| First Trust Advisors LP | 500,273 | $570.3K | 0.00% | +500,273 | New |
| Rhumbline Advisers | 497,240 | $566.8K | 0.00% | −14,239−2.8% | Reduced |
| JPMorgan Chase & Co | 508,484 | $559.3K | 0.00% | −71,294−12.3% | Reduced |
| Alliancebernstein L.P. | 423,190 | $533.2K | 0.00% | −25,000−5.6% | Reduced |
| Kovack Advisors, Inc. | 459,700 | $524.1K | 0.03% | +459,700 | New |
| XTX Topco Ltd | 430,966 | $491.3K | 0.01% | +88,209+25.7% | Added |
| Commonwealth Equity Services, LLC | 430,906 | $491.2K | 0.00% | −210,550−32.8% | Reduced |
| California State Teachers Retirement System | 414,037 | $472.0K | 0.00% | −3,051−0.7% | Reduced |
| Price T Rowe Associates Inc | 404,652 | $462.0K | 0.00% | +37,461+10.2% | Added |
| Qube Research & Technologies Ltd | 404,358 | $461.0K | 0.00% | +301,595+293.5% | Added |
| Susquehanna International Group, LLP | 391,516 | $446.3K | 0.00% | −45,771−10.5% | Reduced |
| Deutsche Bank AG | 370,948 | $422.9K | 0.00% | +45,059+13.8% | Added |
| Legal & General Group Plc | 343,474 | $391.6K | 0.00% | −109,791−24.2% | Reduced |
| EntryPoint Capital, LLC | 342,171 | $390.1K | 0.11% | +33,147+10.7% | Added |
| Zazove Associates LLC | 300,000 | $360.0K | 0.02% | +150,000+100.0% | Added |
| Vanguard Asset Management, Ltd | 294,013 | $335.2K | 0.00% | +294,013 | New |
| Tudor Investment Corp Et Al | 244,821 | $279.1K | 0.00% | 00.0% | Unchanged |
| HSBC Holdings PLC | 238,281 | $272.8K | 0.00% | +238,281 | New |
| Royal Bank of Canada | 219,994 | $251.0K | 0.00% | −41,026−15.7% | Reduced |
| Janus Henderson Group PLC | 206,314 | $236.2K | 0.00% | 00.0% | Unchanged |
| MetLife Investment Management | 204,738 | $233.4K | 0.00% | +29,062+16.5% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 197,906 | $225.6K | 0.00% | +6,802+3.6% | Added |
| Vanguard Global Advisers, LLC | 181,766 | $207.2K | 0.00% | +181,766 | New |
| Creative Planning | 176,985 | $201.8K | 0.00% | +118,924+204.8% | Added |
| State Board of Administration of Florida Retirement System | 176,260 | $200.9K | 0.00% | 00.0% | Unchanged |
| Gamco Investors, Inc. Et Al | 175,000 | $199.5K | 0.00% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 170,000 | $193.8K | 0.00% | −564,747−76.9% | Reduced |
| Gabelli Funds LLC | 170,000 | $193.8K | 0.00% | 00.0% | Unchanged |
| State of Wyoming | 167,020 | $190.4K | 0.02% | +167,020 | New |
| Wells Fargo & Company | 162,609 | $185.4K | 0.00% | −305,909−65.3% | Reduced |
| Van Eck Associates Corp | 160,096 | $183.0K | 0.00% | +23,077+16.8% | Added |
| ProShare Advisors LLC | 140,658 | $160.3K | 0.00% | −15,696−10.0% | Reduced |
| Teton Advisors, LLC | 140,000 | $159.6K | 0.11% | 00.0% | Unchanged |
| Barclays PLC | 138,300 | $157.7K | 0.00% | −524,936−79.1% | Reduced |
| U.S. Capital Wealth Advisors, LLC | 133,261 | $151.9K | 0.00% | +133,261 | New |
| Fifth Third Bancorp | 128,791 | $146.8K | 0.00% | +128,791 | New |
| Tower Research Capital LLC (TRC) | 128,713 | $146.7K | 0.00% | +119,585+1,310.1% | Added |
| Intech Investment Management LLC | 125,814 | $143.4K | 0.00% | −33,838−21.2% | Reduced |
| Manufacturers Life Insurance Company, The | 122,128 | $139.2K | 0.00% | −107,462−46.8% | Reduced |
| Highline Wealth Partners LLC | 116,680 | $133.0K | 0.03% | −10.0% | Reduced |
| Arizona State Retirement System | 115,978 | $132.2K | 0.00% | +2,144+1.9% | Added |
| New York State Common Retirement Fund | 114,301 | $130.3K | 0.00% | 00.0% | Unchanged |
| Glenmede Trust Co NA | 112,750 | $128.5K | 0.00% | −733−0.6% | Reduced |
| Vanguard Investments Australia, Ltd. | 110,958 | $126.5K | 0.00% | +110,958 | New |
| Renaissance Technologies LLC | 109,543 | $124.9K | 0.00% | +109,543 | New |
| Police & Firemen's Retirement System of New Jersey | 102,397 | $116.7K | 0.00% | 00.0% | Unchanged |
| 360 Financial, Inc. | 97,300 | $110.9K | 0.03% | +10,000+11.5% | Added |
| Ameriprise Financial Inc | 96,722 | $110.3K | 0.00% | +480+0.5% | Added |
| Point72 Asset Management, L.P. | 93,335 | $106.4K | 0.00% | +93,335 | New |
| Ieq Capital, LLC | 93,222 | $106.3K | 0.00% | −64,557−40.9% | Reduced |
| KLP Kapitalforvaltning AS | 90,700 | $103.4K | 0.00% | 00.0% | Unchanged |
| HRT Financial LP | 90,759 | $103.0K | 0.00% | −584,724−86.6% | Reduced |
| Cambridge Investment Research Advisors, Inc. | 90,279 | $103.0K | 0.00% | +558+0.6% | Added |
| BNP Paribas Arbitrage, SA | 89,732 | $102.3K | 0.00% | −701−0.8% | Reduced |
| Quadrature Capital Ltd | 88,937 | $101.4K | 0.00% | −2,765−3.0% | Reduced |
| RPg Family Wealth Advisory, LLC | 88,619 | $101.0K | 0.02% | −10,371−10.5% | Reduced |
| SG Americas Securities, LLC | 87,846 | $100.0K | 0.00% | +33,824+62.6% | Added |
| CWM, LLC | 69,834 | $79.6K | 0.00% | +687+1.0% | Added |
| Pensionmark Financial Group, LLC | 66,520 | $75.8K | 0.00% | 00.0% | Unchanged |
| Cascade Financial Partners, LLC | 66,490 | $75.8K | 0.01% | 00.0% | Unchanged |
| Prudential Financial Inc | 65,556 | $74.7K | 0.00% | +39,190+148.6% | Added |
| Pictet Asset Management Holding SA | 65,495 | $74.7K | 0.00% | 00.0% | Unchanged |
| Wealth Enhancement Advisory Services, LLC | 62,365 | $71.1K | 0.00% | +4,836+8.4% | Added |
| Public Employees Retirement Association of Colorado | 61,502 | $70.0K | 0.00% | 00.0% | Unchanged |
| Cetera Investment Advisers | 59,352 | $67.7K | 0.00% | +189+0.3% | Added |
| Kestra Private Wealth Services, LLC | 58,450 | $66.6K | 0.00% | 00.0% | Unchanged |