Lyra Therapeutics, Inc.
LYRADelisted Apr 20, 2026- Industry
- Surgical & Medical Instruments & Apparatus
- SEC CIK
- 0001327273
Lyra Therapeutics, Inc. was delisted on Apr 20, 2026; its insiders filed their last Form 4 on May 15, 2026; 23 institutions reported holding it in 13F filings for Q4 2025, worth $747.3K in total; no superinvestor held it.
13F holders, Q1 2024
Institutional positions in Lyra Therapeutics, Inc. as of Mar 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 79
- +19 vs. Q4 2023
- Shares held
- 45.6M
- +3.21M (+7.6%) vs. Q4 2023
- Total value
- $283.4M
- +$61.4M (+27.7%) vs. Q4 2023
- New holders
- 25
- 30 more added
- Sold out
- 6
- 13 more reduced
Compare with Q4 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 0 | $0 |
| Q1 2026 | 1 | $51.1K |
| Q4 2025 | 23 | $747.3K |
| Q3 2025 | 26 | $2.93M |
| Q2 2025 | 30 | $4.42M |
| Q1 2025 | 57 | $3.23M |
| Q4 2024 | 54 | $5.54M |
| Q3 2024 | 62 | $8.36M |
| Q2 2024 | 51 | $9.06M |
| Q1 2024 | 79 | $283.4M |
| Q4 2023 | 60 | $222.0M |
| Q3 2023 | 45 | $124.8M |
| Q2 2023 | 39 | $138.4M |
| Q1 2023 | 31 | $38.1M |
| Q4 2022 | 37 | $59.9M |
| Q3 2022 | 38 | $96.0M |
| Q2 2022 | 38 | $108.9M |
| Q1 2022 | 28 | $20.2M |
| Q4 2021 | 34 | $22.4M |
| Q3 2021 | 37 | $60.8M |
| Q2 2021 | 46 | $56.0M |
| Q1 2021 | 50 | $87.6M |
Institutions, Q1 2024
Shares, value and share of portfolio for each institution holding Lyra Therapeutics, Inc.; share changes are against Q4 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Perceptive Advisors LLC | 12,757,562 | $79.4M | 1.40% | 00.0% | Unchanged |
| Citadel Advisors LLC | 4,339,101 | $27.0M | 0.03% | +1,477,846+51.7% | Added |
| Nantahala Capital Management, LLC | 2,820,982 | $17.5M | 1.72% | −1,229,236−30.3% | Reduced |
| Samsara BioCapital, LLC | 2,780,261 | $17.3M | 2.68% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 2,742,460 | $17.1M | 0.05% | −257,540−8.6% | Reduced |
| VR Adviser, LLC | 2,576,093 | $16.0M | 0.76% | +5000.0% | Added |
| Vanguard Group Inc | 1,481,481 | $9.21M | 0.00% | +410,021+38.3% | Added |
| Pura Vida Investments, LLC | 1,413,242 | $8.79M | 5.98% | 00.0% | Unchanged |
| Rosalind Advisors, Inc. | 1,144,524 | $7.12M | 6.66% | −744,196−39.4% | Reduced |
| Ikarian Capital, LLC | 1,056,829 | $6.57M | 1.79% | −197,555−15.7% | Reduced |
| Ally Bridge Group (NY) LLC | 1,003,741 | $6.24M | 3.47% | +1,003,741 | New |
| Tri Locum Partners LP | 978,793 | $6.09M | 2.11% | +978,793 | New |
| Vestal Point Capital, LP | 800,000 | $4.98M | 0.41% | −2,200,000−73.3% | Reduced |
| Verition Fund Management LLC | 768,214 | $4.78M | 0.05% | +768,214 | New |
| Laurion Capital Management LP | 747,827 | $4.65M | 0.13% | +705,403+1,662.7% | Added |
| Woodline Partners LP | 676,554 | $4.21M | 0.04% | +76,579+12.8% | Added |
| Parkman Healthcare Partners LLC | 642,245 | $3.99M | 0.49% | −112,640−14.9% | Reduced |
| Ensign Peak Advisors, Inc | 591,311 | $3.68M | 0.01% | +289,778+96.1% | Added |
| Invesco Ltd. | 555,233 | $3.45M | 0.00% | +555,233 | New |
| Walleye Capital LLC | 528,118 | $3.28M | 0.04% | +513,112+3,419.4% | Added |
| Millennium Management LLC | 406,121 | $2.53M | 0.00% | +80,126+24.6% | Added |
| Geode Capital Management, LLC | 359,431 | $2.24M | 0.00% | +22,973+6.8% | Added |
| Schonfeld Strategic Advisors LLC | 357,319 | $2.22M | 0.02% | +315,606+756.6% | Added |
| Susquehanna International Group, LLP | 343,322 | $2.14M | 0.00% | +83,906+32.3% | Added |
| Goldman Sachs Group Inc | 334,665 | $2.08M | 0.00% | +321,602+2,461.9% | Added |
| Hudson Bay Capital Management LP | 250,000 | $1.55M | 0.01% | +250,000 | New |
| Boothbay Fund Management, LLC | 232,670 | $1.45M | 0.04% | −17,269−6.9% | Reduced |
| Dimensional Fund Advisors LP | 190,986 | $1.19M | 0.00% | +78,352+69.6% | Added |
| Two Sigma Investments, LP | 183,743 | $1.14M | 0.00% | +51,137+38.6% | Added |
| Acuta Capital Partners, LLC | 173,320 | $1.08M | 0.70% | +173,320 | New |
| Bank of America Corp | 159,597 | $992.7K | 0.00% | +14,919+10.3% | Added |
| Jane Street Group, LLC | 157,703 | $980.9K | 0.00% | +79,452+101.5% | Added |
| BlackRock Inc. | 151,919 | $944.9K | 0.00% | +41,122+37.1% | Added |
| Superstring Capital Management LP | 145,284 | $903.7K | 0.60% | +145,284 | New |
| Two Sigma Advisers, LP | 143,900 | $895.1K | 0.00% | +93,200+183.8% | Added |
| Qube Research & Technologies Ltd | 131,902 | $820.4K | 0.00% | +76,453+137.9% | Added |
| State Street Corp | 126,180 | $784.8K | 0.00% | +17,000+15.6% | Added |
| Clearline Capital LP | 119,128 | $741.0K | 0.07% | 00.0% | Unchanged |
| Citigroup Inc | 118,875 | $739.4K | 0.00% | −5,568−4.5% | Reduced |
| JPMorgan Chase & Co | 109,405 | $680.5K | 0.00% | +76,235+229.8% | Added |
| HRT Financial LP | 98,525 | $612.0K | 0.00% | +98,525 | New |
| Man Group plc | 90,283 | $561.6K | 0.00% | +52,280+137.6% | Added |
| Bridgeway Capital Management, LLC | 86,800 | $539.9K | 0.01% | −55,000−38.8% | Reduced |
| Marathon Trading Investment Management LLC | 67,010 | $416.8K | 0.17% | +67,010 | New |
| Morgan Stanley | 64,392 | $400.5K | 0.00% | +64,392 | New |
| Northern Trust Corp | 60,495 | $376.3K | 0.00% | −1,054−1.7% | Reduced |
| Renaissance Technologies LLC | 50,900 | $317.0K | 0.00% | +7,000+15.9% | Added |
| Cambridge Investment Research Advisors, Inc. | 41,563 | $259.0K | 0.00% | +41,563 | New |
| Barclays PLC | 32,817 | $204.1K | 0.00% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 32,118 | $200.0K | 0.00% | +3,073+10.6% | Added |
| Letko, Brosseau & Associates Inc | 31,900 | $198.4K | 0.00% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 31,459 | $195.7K | 0.00% | +2,664+9.3% | Added |
| American Century Companies Inc | 25,778 | $160.3K | 0.00% | +25,778 | New |
| Occudo Quantitative Strategies LP | 22,820 | $141.9K | 0.02% | +22,820 | New |
| Omers Administration Corp | 22,200 | $138.1K | 0.00% | +22,200 | New |
| Cubist Systematic Strategies, LLC | 21,160 | $131.6K | 0.00% | −8,470−28.6% | Reduced |
| Y-Intercept (Hong Kong) Ltd | 20,531 | $127.7K | 0.01% | +8,252+67.2% | Added |
| Jump Financial, LLC | 20,187 | $125.6K | 0.00% | +3,450+20.6% | Added |
| Prelude Capital Management, LLC | 15,400 | $95.8K | 0.01% | +15,400 | New |
| Brevan Howard Capital Management LP | 14,042 | $87.3K | 0.01% | +14,042 | New |
| Bank of Montreal | 13,900 | $82.3K | 0.00% | +13,900 | New |
| DLK Investment Management, LLC | 12,000 | $74.6K | 0.03% | 00.0% | Unchanged |
| Virtu Financial LLC | 11,928 | $74.0K | 0.01% | +11,928 | New |
| Squarepoint Ops LLC | 11,670 | $72.6K | 0.00% | +11,670 | New |
| Jefferies Financial Group Inc. | 11,400 | $70.9K | 0.00% | +11,400 | New |
| Engineers Gate Manager LP | 10,718 | $66.7K | 0.00% | +10,718 | New |
| Heritage Wealth Management, Inc./Texas | 10,000 | $62.2K | 0.04% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 8,921 | $55.5K | 0.00% | +6,559+277.7% | Added |
| Catalyst Funds Management Pty Ltd | 8,200 | $51.0K | 0.01% | +8,200 | New |
| Point72 Asia (Singapore) Pte. Ltd. | 5,710 | $35.5K | 0.01% | +5,057+774.4% | Added |
| Advisor Group Holdings, Inc. | 2,000 | $12.4K | 0.00% | 00.0% | Unchanged |
| Comerica Bank | 1,159 | $7.21K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 654 | $4.00K | 0.00% | −2,632−80.1% | Reduced |
| Rhumbline Advisers | 296 | $1.84K | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 251 | $1.56K | 0.00% | +4+1.6% | Added |
| National Bank of Canada | 3,700 | $1.39K | 0.00% | +3,700 | New |
| Northwestern Mutual Wealth Management Co | 100 | $622 | 0.00% | +100 | New |
| UBS Group AG | 18 | $112 | 0.00% | −4,782−99.6% | Reduced |
| Macquarie Group Ltd | 1,375 | $9 | 0.00% | +1,375 | New |
| Armistice Capital, LLC | 0 | $0 | 0.00% | −1,088,000−100.0% | Sold out |
| 683 Capital Management, LLC | 0 | $0 | 0.00% | −69,869−100.0% | Sold out |
| Bank of New York Mellon Corp | 0 | $0 | 0.00% | −18,621−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −12,765−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −1,169−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −200−100.0% | Sold out |