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Lyra Therapeutics, Inc.

LYRADelisted Apr 20, 2026
Industry
Surgical & Medical Instruments & Apparatus
SEC CIK
0001327273

Lyra Therapeutics, Inc. was delisted on Apr 20, 2026; its insiders filed their last Form 4 on May 15, 2026; 23 institutions reported holding it in 13F filings for Q4 2025, worth $747.3K in total; no superinvestor held it.

13F holders, Q3 2021

Institutional positions in Lyra Therapeutics, Inc. as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
37
−9 vs. Q2 2021
Shares held
6.67M
−313.2K (−4.5%) vs. Q2 2021
Total value
$60.8M
+$4.80M (+8.6%) vs. Q2 2021
New holders
3
7 more added
Sold out
12
16 more reduced

Compare with Q2 2021: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting LYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2021: 37 institutions
Q1 2021: 50 institutionsQ2 2021: 46 institutionsQ3 2021: 37 institutionsQ4 2021: 34 institutionsQ1 2022: 28 institutionsQ2 2022: 38 institutionsQ3 2022: 38 institutionsQ4 2022: 37 institutionsQ1 2023: 31 institutionsQ2 2023: 39 institutionsQ3 2023: 45 institutionsQ4 2023: 60 institutionsQ1 2024: 79 institutionsQ2 2024: 51 institutionsQ3 2024: 62 institutionsQ4 2024: 54 institutionsQ1 2025: 57 institutionsQ2 2025: 30 institutionsQ3 2025: 26 institutionsQ4 2025: 23 institutionsQ1 2026: 1 institutionQ2 2026: 0 institutions
Value heldQ3 2021: $60.8M
Q1 2021: $87.6MQ2 2021: $56.0MQ3 2021: $60.8MQ4 2021: $22.4MQ1 2022: $20.2MQ2 2022: $108.9MQ3 2022: $96.0MQ4 2022: $59.9MQ1 2023: $38.1MQ2 2023: $138.4MQ3 2023: $124.8MQ4 2023: $222.0MQ1 2024: $283.4MQ2 2024: $9.06MQ3 2024: $8.36MQ4 2024: $5.54MQ1 2025: $3.23MQ2 2025: $4.42MQ3 2025: $2.93MQ4 2025: $747.3KQ1 2026: $51.1KQ2 2026: $0
Institutions holding LYRA and their total value by quarter
QuarterHoldersValue
Q2 20260$0
Q1 20261$51.1K
Q4 202523$747.3K
Q3 202526$2.93M
Q2 202530$4.42M
Q1 202557$3.23M
Q4 202454$5.54M
Q3 202462$8.36M
Q2 202451$9.06M
Q1 202479$283.4M
Q4 202360$222.0M
Q3 202345$124.8M
Q2 202339$138.4M
Q1 202331$38.1M
Q4 202237$59.9M
Q3 202238$96.0M
Q2 202238$108.9M
Q1 202228$20.2M
Q4 202134$22.4M
Q3 202137$60.8M
Q2 202146$56.0M
Q1 202150$87.6M

Institutions, Q3 2021

Shares, value and share of portfolio for each institution holding Lyra Therapeutics, Inc.; share changes are against Q2 2021.

Institutions holding LYRA in Q3 2021
InstitutionSharesValue% of portfolioChange in sharesAction
Perceptive Advisors LLC3,222,560$29.4M0.43%00.0%Unchanged
Polaris Venture Management Co. V, L.L.C.1,100,852$10.0M71.28%00.0%Unchanged
Pura Vida Investments, LLC533,417$4.87M0.37%−9,227−1.7%Reduced
Ikarian Capital, LLC403,450$3.69M0.84%−221,234−35.4%Reduced
Vanguard Group Inc220,029$2.01M0.00%00.0%Unchanged
Soleus Capital Management, L.P.215,576$1.97M0.31%+32,500+17.8%Added
ArrowMark Colorado Holdings LLC139,187$1.27M0.01%00.0%Unchanged
Parian Global Management LP121,300$1.11M0.79%+121,300New
Millennium Management LLC118,158$1.08M0.00%−36,977−23.8%Reduced
Bank of America Corp110,511$1.01M0.00%+79,524+256.6%Added
Deutsche Bank AG76,352$697.0K0.00%−89−0.1%Reduced
Bridgeway Capital Management, LLC68,900$630.0K0.01%+27,000+64.4%Added
Two Sigma Advisers, LP58,000$529.0K0.00%+14,000+31.8%Added
Boothbay Fund Management, LLC39,200$358.0K0.01%−43,955−52.9%Reduced
Ensign Peak Advisors, Inc39,167$358.0K0.00%00.0%Unchanged
Geode Capital Management, LLC36,018$329.0K0.00%−84−0.2%Reduced
Pentwater Capital Management LP32,014$292.0K0.00%+8,214+34.5%Added
Morgan Stanley30,163$275.0K0.00%−55,248−64.7%Reduced
BlackRock Inc.17,818$163.0K0.00%−2,302−11.4%Reduced
Ergoteles LLC16,273$149.0K0.01%−14,727−47.5%Reduced
Susquehanna International Group, LLP15,895$145.0K0.00%−5,634−26.2%Reduced
Two Sigma Investments, LP13,384$122.0K0.00%−10,500−44.0%Reduced
Marshall Wace, LLP12,457$114.0K0.00%−6,864−35.5%Reduced
Trexquant Investment LP11,085$101.0K0.01%−525−4.5%Reduced
Close Asset Management Ltd7,000$64.0K0.00%+7,000New
Tower Research Capital LLC (TRC)4,235$38.0K0.00%+2,838+203.1%Added
Advisor Group Holdings, Inc.1,234$12.0K0.00%−3,200−72.2%Reduced
Cardinal Capital Management, Inc.650$6.00K0.00%00.0%Unchanged
US Bancorp500$5.00K0.00%00.0%Unchanged
Wells Fargo & Company537$5.00K0.00%+14+2.7%Added
Laurel Wealth Advisors LLC500$5.00K0.00%00.0%Unchanged
Royal Bank of Canada287$3.00K0.00%−109−27.5%Reduced
Harbour Investments, Inc.175$2.00K0.00%00.0%Unchanged
Koshinski Asset Management, Inc.200$1.82K0.00%+200New
UBS Group AG18$00.00%−549−96.8%Reduced
JPMorgan Chase & Co34$00.00%00.0%Unchanged
Investors Research Corp15$00.00%00.0%Unchanged
Blair William & Co0$00.00%−55,000−100.0%Sold out
Tibra Equities Europe Ltd0$00.00%−40,000−100.0%Sold out
ExodusPoint Capital Management, LP0$00.00%−31,539−100.0%Sold out
Citadel Advisors LLC0$00.00%−19,381−100.0%Sold out
Walleye Capital LLC0$00.00%−19,093−100.0%Sold out
HRT Financial LP0$00.00%−18,602−100.0%Sold out
Goldman Sachs Group Inc0$00.00%−10,751−100.0%Sold out
New York State Common Retirement Fund0$00.00%−62−100.0%Sold out
Citigroup Inc0$00.00%−49−100.0%Sold out
Toth Financial Advisory Corp0$00.00%−50−100.0%Sold out
Quadrant Capital Group LLC0$00.00%−49−100.0%Sold out
Parallel Advisors, LLC0$00.00%−10−100.0%Sold out