Lyra Therapeutics, Inc.
LYRADelisted Apr 20, 2026- Industry
- Surgical & Medical Instruments & Apparatus
- SEC CIK
- 0001327273
Lyra Therapeutics, Inc. was delisted on Apr 20, 2026; its insiders filed their last Form 4 on May 15, 2026; 23 institutions reported holding it in 13F filings for Q4 2025, worth $747.3K in total; no superinvestor held it.
Holders of 5% or more of LYRA
Holders whose latest Schedule 13D or 13G filing reports 5% or more of Lyra Therapeutics, Inc., largest stake first. The change is against the holder's previous filing.
| Holder | Latest form | Stake | Change | First filed | Latest filing | Filing |
|---|---|---|---|---|---|---|
| Perceptive Advisors LLC | 13D/A | 15.55%255.8K shares | – | Aug 14, 20251 filing | Aug 14, 2025 | SEC |
| Sabby Management, LLC | 13G | 9.90%175.2K shares | New | Jan 20, 20261 filing | Jan 20, 2026 | SEC |
Stakes are as of each holder's latest filing. Holders whose last filing was in the old format (before December 18, 2024) have no stake on record and are not listed, and after an acquisition or delisting holders usually stop filing.
13D and 13G filings
8 Schedule 13D and 13G filings on Lyra Therapeutics, Inc., newest first, including old-format filings without a stake.
| Filed (ET) | Filer | Form | Stake | Change | Event date | Filing |
|---|---|---|---|---|---|---|
| Jan 20, 20267:18 PM ET | Sabby Management, LLCand 2 others | 13G | 9.90%175.2K shares | New | Dec 31, 2025 | SEC |
| Nov 25, 20254:24 PM ET | Perceptive Advisors LLCand 3 others | 13D/A | 0.00%0 shares | −5.50 ppfrom 5.50%Below 5% | Nov 21, 2025 | SEC |
| Nov 18, 20254:14 PM ET | Perceptive Advisors LLCand 3 others | 13D/A | 5.50%98.3K shares | −2.30 ppfrom 7.80% | Nov 14, 2025 | SEC |
| Nov 13, 20255:05 PM ET | Perceptive Advisors LLCand 3 others | 13D/A | 7.80%138.9K shares | −3.40 ppfrom 11.20% | Nov 11, 2025 | SEC |
| Nov 10, 20255:07 PM ET | Perceptive Advisors LLCand 3 others | 13D/A | 11.20%184.8K shares | – | Nov 6, 2025 | SEC |
| Aug 14, 20255:21 PM ET | Perceptive Advisors LLCand 3 others | 13D/A | 15.55%255.8K shares | – | Aug 12, 2025 | SEC |
| Feb 14, 20256:22 PM ET | Citadel Advisors LLCand 6 others | 13G/A | 0.00%21.1K shares | –Below 5% | Dec 31, 2024 | SEC |
| Nov 14, 20244:53 PM ET | Nantahala Capital Management, LLCand 2 others | 13G/A | 1.06%702.1K shares | –Below 5% | Sep 30, 2024 | SEC |
| Feb 14, 2023 | Pura Vida Investments, LLC | 13G/AOld format | – | – | – | SEC |
| Feb 14, 2023 | Nantahala Capital Management, LLC | 13GOld format | – | New | – | SEC |
| Feb 14, 2023 | Venrock Healthcare Capital Partners II, L.P. | 13G/AOld format | – | – | – | SEC |
| Feb 13, 2023 | Intersouth Partners VII L P | 13G/AOld format | – | – | – | SEC |
| Feb 7, 2023 | Polaris Venture Partners V, L.P. | 13G/AOld format | – | – | – | SEC |
| Nov 8, 2022 | Pura Vida Investments, LLC | 13GOld format | – | New | – | SEC |
| Apr 22, 2022 | NBVM GP, LLC | 13D/AOld format | – | – | – | SEC |
| Apr 22, 2022 | Venrock Healthcare Capital Partners II, L.P. | 13GOld format | – | New | – | SEC |
| Apr 14, 2022 | Perceptive Advisors LLC | 13D/AOld format | – | – | – | SEC |
| Feb 14, 2022 | Ikarian Capital, LLC | 13G/AOld format | – | – | – | SEC |
| Feb 14, 2022 | ArrowMark Colorado Holdings LLC | 13G/AOld format | – | – | – | SEC |
| May 17, 2021 | Ra Capital Management, L.P. | 13G/AOld format | – | – | – | SEC |
| Feb 16, 2021 | Ikarian Capital, LLC | 13G/AOld format | – | – | – | SEC |
| Feb 16, 2021 | ArrowMark Colorado Holdings LLC | 13GOld format | – | New | – | SEC |
| Feb 16, 2021 | Ra Capital Management, L.P. | 13GOld format | – | New | – | SEC |
| Feb 12, 2021 | Polaris Venture Partners V, L.P. | 13GOld format | – | New | – | SEC |
| Feb 12, 2021 | Intersouth Partners VII L P | 13GOld format | – | New | – | SEC |
Form 144: proposed insider sales
Notices from officers, directors and other affiliates planning to sell Lyra Therapeutics, Inc. shares.
No Form 144 notices for Lyra Therapeutics, Inc. are on file.